Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Shayn M Peirce"'
Publikováno v:
eLife, Vol 13 (2024)
Muscle regeneration is a complex process due to dynamic and multiscale biochemical and cellular interactions, making it difficult to identify microenvironmental conditions that are beneficial to muscle recovery from injury using experimental approach
Externí odkaz:
https://doaj.org/article/d02bd5ffa1d44c46b205c29d5d4b9ad3
Autor:
Tracy J Kuper, Mohammad Mazharul Islam, Shayn M Peirce-Cottler, Jason A Papin, Roseanne M Ford
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012031 (2024)
With the generation of spatially resolved transcriptomics of microbial biofilms, computational tools can be used to integrate this data to elucidate the multi-scale mechanisms controlling heterogeneous biofilm metabolism. This work presents a Multi-s
Externí odkaz:
https://doaj.org/article/c9d808f3db5e4d5bb8d1a446440efb2d
Autor:
Christopher J Skalnik, Sean Y Cheah, Mica Y Yang, Mattheus B Wolff, Ryan K Spangler, Lee Talman, Jerry H Morrison, Shayn M Peirce, Eran Agmon, Markus W Covert
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011232 (2023)
Antibiotic resistance poses mounting risks to human health, as current antibiotics are losing efficacy against increasingly resistant pathogenic bacteria. Of particular concern is the emergence of multidrug-resistant strains, which has been rapid amo
Externí odkaz:
https://doaj.org/article/c586e70966d047e2adda5d4777ce5255
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011166 (2023)
[This corrects the article DOI: 10.1371/journal.pcbi.1010701.].
Externí odkaz:
https://doaj.org/article/e53a78f4f68c4c8eaf90b8f33f7c89a1
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010701 (2022)
Physiological and pathological processes including embryogenesis and tumorigenesis rely on the ability of individual cells to work collectively to form multicell patterns. In these heterogeneous multicell systems, cell-cell signaling induces differen
Externí odkaz:
https://doaj.org/article/ea184f56d28347369bdaa993dc976a2b
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008937 (2021)
Skeletal muscle possesses a remarkable capacity for repair and regeneration following a variety of injuries. When successful, this highly orchestrated regenerative process requires the contribution of several muscle resident cell populations includin
Externí odkaz:
https://doaj.org/article/9fefe0cb9d6642b49afa28d9f21bc8bb
Autor:
Catherine C Henry, Kyle S Martin, Bridget B Ward, Geoffrey G Handsfield, Shayn M Peirce, Silvia S Blemker
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183853 (2017)
Duchenne muscular dystrophy (DMD) is a progressive degenerative disease that results in fibrosis and atrophy of muscles. The main cause of death associated with DMD is failure of the diaphragm. The diaphragm is a dome-shaped muscle with a fiber micro
Externí odkaz:
https://doaj.org/article/df96e367d22e4bddb56279640e273edb
Autor:
Thomas A Mendel, Erin B D Clabough, David S Kao, Tatiana N Demidova-Rice, Jennifer T Durham, Brendan C Zotter, Scott A Seaman, Stephen M Cronk, Elizabeth P Rakoczy, Adam J Katz, Ira M Herman, Shayn M Peirce, Paul A Yates
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65691 (2013)
BACKGROUND:Retinal vasculopathies, including diabetic retinopathy (DR), threaten the vision of over 100 million people. Retinal pericytes are critical for microvascular control, supporting retinal endothelial cells via direct contact and paracrine me
Externí odkaz:
https://doaj.org/article/06102e191bf94677a7bdf05bf28ff77b
Publikováno v:
Frontiers in Physiology, Vol 2 (2011)
Experimental data indicates that soluble VEGF receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by vascular endothelial growth factor-A (VEGF). To better delineate the role of sFlt-1 in VEGF signaling, we have develo
Externí odkaz:
https://doaj.org/article/8d944f362f994fd0ac0a60bbcbf22317
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20807 (2011)
Quantification of microvascular network structure is important in a myriad of emerging research fields including microvessel remodeling in response to ischemia and drug therapy, tumor angiogenesis, and retinopathy. To mitigate analyst-specific variat
Externí odkaz:
https://doaj.org/article/9f4c82c65e154817ab68cac01c803a64