Prevalence of sexual dimorphism in mammalian phenotypic traits

Autor: Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. Dickinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. Lelliott, K.C. Kent Lloyd, Ann-Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, International Mouse Phenotyping Consortium, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory se

Externí odkaz: https://doaj.org/article/903b3cd9e9ab44c786e930b7a65ed71e

Prevalence of sexual dimorphism in mammalian phenotypic traits

Autor: Damian Smedley, Colin McKerlie, Xiang Gao, Henrik Westerberg, Simon Greenaway, Monica J. Justice, Hiroshi Masuya, Elissa J. Chesler, Robert E. Braun, Mary E. Dickinson, Shay Yaacoby, Stephen A. Murray, Karen L. Svenson, Jeremy Mason, Martin Hrabé de Angelis, Luis Santos, Tania Sorg, Christopher J. Lelliott, Sara Wells, Ann M. Flenniken, Ruth Heller, Ann-Marie Mallon, Lynette Bower, Karen P. Steel, Helen Parkinson, Judith E. Mank, Arthur L. Beaudet, Kevin C K Lloyd, Richard Mott, Yann Herault, Yoav Benjamini, Jacqueline K. White, Steve D.M. Brown, Shiying Guo, John R. Seavitt, Helmut Fuchs, Natalja Kurbatova, Anneliese O. Speak, Natasha A. Karp, Ramiro Ramirez-Solis, Terrence F. Meehan, David B. West, Shigeharu Wakana

Publikováno v: Nature Communications
Nature Communications, 2017, 8, ⟨10.1038/ncomms15475⟩
Nature communications, vol 8, iss 1
Nat. Commun. 8:15475 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22ff32917f16b5f536bab3a8bab6e17
https://hal.science/hal-03679179/file/islandora_77521.pdf

repfdr: a tool for replicability analysis for genome-wide association studies

Autor: Shay Yaacoby, Daniel Yekutieli, Ruth Heller

Publikováno v: Bioinformatics. 30:2971-2972

Motivation: Identification of single nucleotide polymorphisms that are associated with a phenotype in more than one study is of great scientific interest in the genome-wide association studies (GWAS) research. The empirical Bayes approach for discove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d66737a77c1c9b57f08b832b3d73dbf
https://doi.org/10.1093/bioinformatics/btu434