Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Shay Soker"'
Autor:
Azza M. El-Derby, Cecilia R. Schaaf, Ethan Shelkey, Katherine L. Cook, Konstantinos I. Votanopoulos, Shay Soker
Publikováno v:
Frontiers in Microbiomes, Vol 3 (2024)
Immunotherapies are a revolutionary approach to treating cancer by utilizing the body’s immune system to target and combat cancer cells. This approach offers promising alternatives to traditional chemotherapies. Its potential to induce long-lasting
Externí odkaz:
https://doaj.org/article/309c00da05ab4fd880ee8e3239373246
Autor:
Steven D. Forsythe, Richard A. Erali, Nicholas Edenhoffer, William Meeker, Nadeem Wajih, Cecilia R. Schaaf, Preston Laney, Cristian D. Vanezuela, Wencheng Li, Edward A. Levine, Shay Soker, Konstantinos I. Votanopoulos
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10–15% of all mesothelioma cases. Herein we apply PM patient-derived tumor organoids (PTOs) in elucidating personalized HIPEC responses to bypass rar
Externí odkaz:
https://doaj.org/article/b06ce63a27604f8892e9538a0600cbd8
Autor:
Steven D. Forsythe, Richard A. Erali, Preston Laney, Hemamylammal Sivakumar, Wencheng Li, Aleksander Skardal, Shay Soker, Konstantinos I. Votanopoulos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous cancer, with incidence of less than 1/100,000, low survival rates and variable response to chemotherapy or immunotherapy. Herein we explore the application of patient tumor organ
Externí odkaz:
https://doaj.org/article/b1099e5798d44799b77029561bf17af0
Autor:
Gemma Nomdedeu-Sancho, Anastasiya Gorkun, Naresh Mahajan, Kelsey Willson, Cecilia R. Schaaf, Konstantinos I. Votanopoulos, Anthony Atala, Shay Soker
Publikováno v:
Cancers, Vol 15, Iss 24, p 5779 (2023)
Melanoma is responsible for the majority of skin cancer-related fatalities. Immune checkpoint inhibitor (ICI) treatments have revolutionized the management of the disease by significantly increasing patient survival rates. However, a considerable num
Externí odkaz:
https://doaj.org/article/1af33dfcd3854d2f8527d27534d1b850
Autor:
Ethan Shelkey, David Oommen, Elizabeth R. Stirling, David R. Soto-Pantoja, Katherine L. Cook, Yong Lu, Konstantinos I. Votanopoulos, Shay Soker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immune checkpoint blockade (ICB) therapy has demonstrated good efficacy in many cancer types. In cancers such as non-resectable advanced or metastatic triple-negative breast cancer (TNBC), it has recently been approved as a promising treatme
Externí odkaz:
https://doaj.org/article/5c0af050e5bb463a924dd9fa2d10f574
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Colorectal cancer (CRC) treatment is currently hindered by micrometastatic relapse that cannot be removed completely during surgery and is often chemotherapy resistant. Targeted theranostic nanoparticles (NPs) that can produce heat for ablat
Externí odkaz:
https://doaj.org/article/25d4a3527b974cd492f287ed093df784
Autor:
Sean V. Murphy, Aleksander Skardal, Ronald A. Nelson Jr., Khiry Sunnon, Tanya Reid, Cara Clouse, Nancy D. Kock, John Jackson, Shay Soker, Anthony Atala
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 80-92 (2020)
Abstract There is a need for effective wound treatments that retain the bioactivity of a cellular treatment, but without the high costs and complexities associated with manufacturing, storing, and applying living biological products. Previously, we d
Externí odkaz:
https://doaj.org/article/f3a83fdd38d34788bd448cab9a77acb7
Autor:
Matthew Brovold, Dale Keller, Mahesh Devarasetty, Anthony Dominijanni, Rohan Shirwaiker, Shay Soker
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 3, Pp n/a-n/a (2021)
Abstract Congenital disorders of the biliary tract are the primary reason for pediatric liver failure and ultimately for pediatric liver transplant needs. Not all causes of these disorders are well understood, but it is known that liver fibrosis occu
Externí odkaz:
https://doaj.org/article/6e60382fedb748c1a4a46c8552ca9e0f
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101851- (2020)
Summary: Tumors comprised a tightly surrounded tumor microenvironment, made up of non-cellular extracellular matrix (ECM) and stromal cells. Although treatment response is often attributed to tumor heterogeneity, progression and malignancy are profou
Externí odkaz:
https://doaj.org/article/40fdf32883604c73aa7c90b2703b96b9
Autor:
Aleksander Skardal, Sean V. Murphy, Mahesh Devarasetty, Ivy Mead, Hyun-Wook Kang, Young-Joon Seol, Yu Shrike Zhang, Su-Ryon Shin, Liang Zhao, Julio Aleman, Adam R. Hall, Thomas D. Shupe, Andre Kleensang, Mehmet R. Dokmeci, Sang Jin Lee, John D. Jackson, James J. Yoo, Thomas Hartung, Ali Khademhosseini, Shay Soker, Colin E. Bishop, Anthony Atala
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Many drugs have progressed through preclinical and clinical trials and have been available – for years in some cases – before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation from drug
Externí odkaz:
https://doaj.org/article/545c3d4e24814f1fb722fae0fa19632f