Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Shay LE"'
Autor:
Ah-Jung Jeon, Yue-Yang Teo, Karthik Sekar, Shay Lee Chong, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Adaikalavan Ramasamy, Gokce Oguz, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D.dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K. P. Goh, Greg Tucker-Kellogg, Roger Sik Yin Foo, Pierce K. H. Chow
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is especi
Externí odkaz:
https://doaj.org/article/ac89eae58a5449229b3b4f7dcae89062
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Mycobacteroides abscessus complex (MABC), an emerging pathogen, causes human infections resistant to multiple antibiotics. In this study, the genome data of 1,581 MABC strains were downloaded from NCBI database for phylogenetic re
Externí odkaz:
https://doaj.org/article/ef77d559f48348938c73054d23566cee
Autor:
Ah-Jung Jeon, Chukwuemeka George Anene-Nzelu, Yue-Yang Teo, Shay Lee Chong, Karthik Sekar, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Alexander Yaw Fui Chung, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D. dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K.P. Goh, Roger Sik Yin Foo, Pierce Kah-Hoe Chow
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100715- (2023)
Background & Aims: Lifestyle and environmental-related exposures are important risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation significantly underpins HCC. We profiled 30 surgically resected tumours and the m
Externí odkaz:
https://doaj.org/article/60b0d493517247318069a8fdb601a422
Autor:
Matthew D. Parker, Hazel Stewart, Ola M. Shehata, Benjamin B. Lindsey, Dhruv R. Shah, Sharon Hsu, Alexander J. Keeley, David G. Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F. Louka, Hailey R. Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H. Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E. Hansford, Luke R. Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew E. Firth, James R. Edgar, Silvana Gaudieri, Simon Mallal, The COVID-19 Genomics UK (COG-UK) consortium, Mark O. Collins, Andrew A. Peden, Thushan I. de Silva
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Matthew Parker et al. use the ARTIC network tiled amplicon PCR and Oxford Nanopore sequencing of thousands of SARS-CoV-2 samples to detect subgenomic RNA changes in the B.1.1.7 lineage endemic in the UK in late 2020/early 2021. They discovered higher
Externí odkaz:
https://doaj.org/article/a4136fc5fe3f462ca4c6714d58abfce9
Autor:
Anuradha Sooda, Francois Rwandamuriye, Celestine N. Wanjalla, Lichen Jing, David M. Koelle, Bjoern Peters, Shay Leary, Abha Chopra, Michael A. Calderwood, Simon A. Mallal, Rebecca Pavlos, Mark Watson, Elizabeth J. Phillips, Alec J. Redwood
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
HLA-B*57:01 restricted EBV-specific T-cell receptor specificity is altered by abacavir, suggesting a potentially inhibitory effect of abacavir on HLA-B*57:01 restricted TCR recognition.
Externí odkaz:
https://doaj.org/article/bcdd7ff4c80c420a8da2e27c19a3a258
Autor:
Jennifer Currenti, Joshua Simmons, Jared Oakes, Silvana Gaudieri, Christian M. Warren, Rama Gangula, Eric Alves, Ramesh Ram, Shay Leary, Jesse D. Armitage, Rita M. Smith, Abha Chopra, Natasha B. Halasa, Mark A. Pilkinton, Spyros A. Kalams
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionA vaccine against influenza is available seasonally but is not 100% effective. A predictor of successful seroconversion in adults is an increase in activated circulating T follicular helper (cTfh) cells after vaccination. However, the imp
Externí odkaz:
https://doaj.org/article/f40a8c36fec04b7983ba1f4e01772959
Autor:
Eric Alves, Marwah Al-Kaabi, Niamh M Keane, Shay Leary, Coral-Ann M Almeida, Pooja Deshpande, Jennifer Currenti, Abha Chopra, Rita Smith, Alison Castley, Simon Mallal, Spyros A Kalams, Silvana Gaudieri, Mina John
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010965 (2022)
Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a major driver of human immunodeficiency virus (HIV) evolution at both the individual and population level. To date, there has been limited exploration of the impact of
Externí odkaz:
https://doaj.org/article/5b3936e98d094b46928ee18e598394bf
Autor:
Jennifer Currenti, Becker M.P. Law, Kai Qin, Mina John, Mark A. Pilkinton, Anju Bansal, Shay Leary, Ramesh Ram, Abha Chopra, Rama Gangula, Ling Yue, Christian Warren, Louise Barnett, Eric Alves, Wyatt J. McDonnell, Anuradha Sooda, Sonya L. Heath, Simon Mallal, Paul Goepfert, Spyros A. Kalams, Silvana Gaudieri
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another described, but less understood, adaptation strategy involves the selection of mutations with
Externí odkaz:
https://doaj.org/article/d451789591d94ef98727693bea82eac9
Autor:
Shelley Waters, Mark Agostino, Silvia Lee, Ibnu Ariyanto, Nina Kresoje, Shay Leary, Kylie Munyard, Silvana Gaudieri, Jessica Gaff, Ashley Irish, Anthony D. Keil, Patricia Price, Richard J. N. Allcock
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Human cytomegalovirus (HCMV) is a beta-herpesvirus carried by ∼80% of the world’s population. Acute infections are asymptomatic in healthy individuals but generate diverse syndromes in neonates, solid organ transplant recipients, and HIV
Externí odkaz:
https://doaj.org/article/2695996f9dd54fd7acb7bbc9e9cec846
Autor:
Shay Leary, Silvana Gaudieri, Matthew Parker, Abha Chopra, Ian James, Suman Pakala, Eric Alves, Mina John, Benjamin Lindsey, Alexander Keeley, Sarah Rowland-Jones, Maurice Swanson, David Ostrov, Jodi Bubenik, Suman Das, John Sidney, Alessandro Sette, COVID-19 Genomics UK (COG-UK) consortium, Thushan de Silva, Elizabeth Phillips, Simon Mallal
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 2 (2021)
Background: Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host’s anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino
Externí odkaz:
https://doaj.org/article/0e6cb380ed5c485f8c8e44524bb4614b