Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shay Bar-Haim"'
Publikováno v:
Journal of Chemical Information and Modeling. 49:623-633
Identifying active compounds (hits) that bind to biological targets of pharmaceutical relevance is the cornerstone of drug design efforts. Structure based virtual screening, namely, the in silico evaluation of binding energies and geometries between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12892b5131d5ca641c7dbd26ad68d62c
https://doi.org/10.1021/ci800335j
https://doi.org/10.1021/ci800335j
Autor:
Yael Marantz, Alexander Heifetz, Dora Warshaviak, Silvia Noiman, Boaz Inbal, Maya Topf, Merav Fichman, Oren M. Becker, Zvi Naor, Noa Avisar, Sharon Shacham, Ori Kalid, Shay Bar-Haim
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 57:51-86
G-protein coupled receptors (GPCRs) are a major group of drug targets for which only one x-ray structure is known (the nondrugable rhodopsin), limiting the application of structure-based drug discovery to GPCRs. In this paper we present the details o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f73d8d55d83853d9da9bf9ea2b2dc1
https://doi.org/10.1002/prot.20195
https://doi.org/10.1002/prot.20195
Autor:
Oren Becker, Sharon Shacham, Zvi Naor, Silvia Noiman, Maya Topf, Fabian Glaser, Yael Marantz, Shay Bar-Haim, Noa Avisar
Publikováno v:
Medicinal Research Reviews. 21:472-483
G-protein-coupled receptors (GPCRs) are a large and functionally diverse protein superfamily, which form a seven transmembrane (TM) helices bundle with alternating extra-cellular and intracellular loops. GPCRs are considered to be one of the most imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4edc3709346c850e82f75abbeaa49f
https://doi.org/10.1002/med.1019
https://doi.org/10.1002/med.1019
Publikováno v:
Experimental Hematology. 28:1029-1038
Objective Molecular identification and characterization of the bone marrow nuclear protein detected by the B92 monoclonal antibody. Materials and Methods The protein was purified to homogeneity from acute myeloid leukemia cells and was subjected to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585217a79d65369faa103b56a7fa97e9
https://doi.org/10.1016/s0301-472x(00)00510-5
https://doi.org/10.1016/s0301-472x(00)00510-5
Autor:
Oren Becker, Sharon Shacham, Maya Topf, Shay Bar-Haim, Silvia Noiman, Noa Avisar, Zvi Naor, Yael Marantz, Fabian Glaser
Publikováno v:
ChemInform. 32
G-protein-coupled receptors (GPCRs) are a large and functionally diverse protein superfamily, which form a seven transmembrane (TM) helices bundle with alternating extracellular and intracellular loops. GPCRs are considered to be one of the most impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab1c20c3c40bad4455eb445cb0d0b518
https://doi.org/10.1002/chin.200144294
https://doi.org/10.1002/chin.200144294
Autor:
Yael Marantz, I. Sela, Y. Markus, M. Strajbl, G. Golan, Ori Kalid, Alina Shitrit, I. Bloch, B. Inbal, Hanoch Senderowitz, Efrat Ben-Zeev, D. Rivenzon-Segal, Merav Fichman, Shay Bar-Haim
Publikováno v:
Current topics in medicinal chemistry. 10(6)
In silico drug discovery is a complex process requiring flexibility and ingenuity in method selection and a careful validation of work protocols. GPCR in silico drug discovery poses additional challenges due to the paucity of crystallographic data. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3308e072339eb9462776dc1b48857966
https://pubmed.ncbi.nlm.nih.gov/20337589
https://pubmed.ncbi.nlm.nih.gov/20337589
Autor:
Merav Fichman, Oren M. Becker, Sharon Shacham, Dora Warshaviak, Shay Bar-Haim, Silvia Noiman, Boaz Inbal, Ori Kalid, Alexander Heifetz, Yael Marantz
The application of structure-based in silico methods to drug discovery is still considered a major challenge, especially when the x-ray structure of the target protein is unknown. Such is the case with human G protein-coupled receptors (GPCRs), one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507cf343de0fe9320a4ed5905da87dd
https://europepmc.org/articles/PMC509175/
https://europepmc.org/articles/PMC509175/
Publikováno v:
Journal of cellular biochemistry. 81(3)
Differentiation in several stem cell systems is associated with major morphological changes in global nuclear shape. We studied the fate of inner-nuclear structures, splicing factor-rich foci and Cajal (coiled) bodies in differentiating hemopoietic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a875db985ee4c660927923b85185caa5
https://pubmed.ncbi.nlm.nih.gov/11255221
https://pubmed.ncbi.nlm.nih.gov/11255221
Publikováno v:
Journal of Chemical Information & Modeling; Mar2009, Vol. 49 Issue 3, p623-633, 11p