Výsledky vyhledávání - "Shawna McLetchie"

Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation

Autor: Veronica Saenz, Mason J. Ryan, Roberto Ibáñez, Florence Ann Sobell, Shawna McLetchie, Allison Q. Byrne, Douglas C. Woodhams, Rachel Perez, Corinne L. Richards-Zawacki, Jamie Voyles, Julie M. Ray, Erica Bree Rosenblum, Molly C. Bletz, Edgardo Griffith, Louise A. Rollins-Smith, Heidi Ross, Gabriela Rios-Sotelo, Laura K. Reinert

Publikováno v: Science. 359:1517-1519

Resistance is not futile The fungal disease chytridiomycosis has wreaked havoc on amphibians worldwide. The disease is caused by the organism Batrachochytrium dendrobatidis and was first identified in the late 1990s. Voyles et al. revisited protected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171a7e5c9b62f53c2031b1bd0f7faf3
https://doi.org/10.1126/science.aao4806

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AMPKα1 in B cells promotes memory B cell longevity and mitochondrial homeostasis while dampening antibody synthesis

Autor: Shawna McLetchie, Sung Hoon Cho, Paulo Basso, Mark Robin Boothby

Publikováno v: The Journal of Immunology. 204:71.7-71.7

Emerging evidence indicates that metabolic programs regulate B cell activation and antibody responses. However, the metabolic mediators that support the durability of the memory B cell and long-lived plasma cell populations are not fully elucidated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1a9e4185b246596eda15d89476b9f4a
https://doi.org/10.4049/jimmunol.204.supp.71.7

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Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts

Autor: Mary C. Dinauer, Shawna McLetchie, Bryan D. Volpp, Janice S. Blum

Publikováno v: Immunology. 146:595-606

Chronic granulomatous disease (CGD) is an inherited immunodeficiency linked with mutations in the multi-subunit leucocyte NADPH oxidase. Myeloid-derived phagocytic cells deficient in NADPH oxidase fail to produce sufficient levels of reactive oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24d55105fa6e8a4b31225da73046cb5
https://doi.org/10.1111/imm.12530

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LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy

Autor: Liliana Pérez, Delu Zhou, Gail J. Gardiner, Janice S. Blum, Shawna McLetchie, Sarah N. Deffit

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 196(6)

Cells use multiple autophagy pathways to sequester macromolecules, senescent organelles, and pathogens. Several conserved isoforms of the lysosome-associated membrane protein-2 (LAMP-2) regulate these pathways influencing immune recognition and respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1007bd7df0cb65ac3495e0c6c93c5aa
https://pubmed.ncbi.nlm.nih.gov/26856698

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mTORC1 in B cells regulates antibody responses and promotes mitochondrial and metabolic fitness

Autor: Shawna McLetchie, Ariel Raybuck, Sung Hoon Cho, Jingxin Lin, Mark Robin Boothby

Publikováno v: The Journal of Immunology. 198:195.13-195.13

B lymphocytes migrate among different micro-anatomic sites for diversification, selection, and eventual differentiation into antibody-secreting plasma cells. Emerging evidence supports the premise that aspects of the nutrient milieu vary within lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f722d689fe4a6fa6fce86982c698fbc9
https://doi.org/10.4049/jimmunol.198.supp.195.13

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A Role for NADPH Oxidase in Antigen Presentation

Autor: Janice S. Blum, Sarah N. Deffit, Gail J. Gardiner, Crystal C. Walline, Shawna McLetchie, Liliana Pérez

Publikováno v: Frontiers in Immunology, Vol 4 (2013)
Frontiers in Immunology

The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d49781b5f8642856db889f8ae0aad8
https://doi.org/10.3389/fimmu.2013.00295

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Spatial variability in airborne bacterial communities across land-use types and their relationship to the bacterial communities of potential source environments

Autor: Robert M. Bowers, Shawna McLetchie, Rob Knight, Noah Fierer

Publikováno v: The ISME journal. 5(4)

Although bacteria are ubiquitous in the near-surface atmosphere and they can have important effects on human health, airborne bacteria have received relatively little attention and their spatial dynamics remain poorly understood. Owing to differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d64f23ac9d86b0e1ffce20b2811dcea
https://pubmed.ncbi.nlm.nih.gov/21048802

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Hyper-responsive TLR7 and TLR9 activation in NADPH oxidase-deficient human B cells (HUM1P.272)

Autor: Shawna McLetchie, Gail Gardiner, Janice Blum

Publikováno v: The Journal of Immunology. 194:52.21-52.21

Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency linked with mutations in the multi-component leukocyte NADPH oxidase. Phagocytic cells deficient in NADPH oxidase fail to produce sufficient levels of the reactive oxygen species (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63ad999ddee704f3f9a80a720173c248
https://doi.org/10.4049/jimmunol.194.supp.52.21

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