Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shawn Y. Stevens"'
Publikováno v:
International Journal of Science and Mathematics Education. 17:295-315
A coherent curriculum that clearly defines sets of ideas that build upon one another to meet desired learning goals can successfully support the development of meaningful understanding across time. This study explores the influence of a coherent curr
Publikováno v:
Educación Química. 24:381-390
The development of learning progressions is one approach for creating the types of coherent curriculum frameworks that have been identified as predictors for high-performing scores on international stem assessments. We have developed a learning progr
Publikováno v:
Teaching and Teacher Education. 27:797-810
Teachers need to develop the ability to adapt curriculum materials. Two elementary teachers, Maggie and Catie, were asked to write narratives about their use of and changes to particular reform-oriented science lesson plans. Maggie drew on her knowle
Publikováno v:
Journal of Research in Science Teaching. 47:687-715
We describe efforts toward the development of a hypothetical learning progression (HLP) for the growth of grade 7-14 students' models of the structure, behavior and properties of matter, as it relates to nanoscale science and engineering (NSE). This
Publikováno v:
Protein Science. 12:2588-2596
The Hsp70 family of molecular chaperones participates in a number of cellular processes, including binding to nascent polypeptide chains and assistance in protein (re)folding and degradation. We present the solution structure of the substrate binding
Publikováno v:
Nanotechnology Reviews. 4
Size and scale is a “big idea” in nanoscale science and engineering and is poorly understood by secondary students. This paper describes the design process, implementation, and evaluation of a 12-h instructional unit for size and scale, in a summ
Publikováno v:
Biochemistry. 42:11100-11108
The interaction of solvent of the substrate binding domain of the bacterial heat shock 70 chaperone protein DnaK was studied in its apo form and with bound hydrophobic substrate peptide, using refined nuclear magnetic resonance experiments. Distinct
Publikováno v:
Nature Structural Biology. 8:947-952
The dimeric enzyme CTP:glycerol-3-phosphate cytidylyltransferase (GCT) displays strong negative cooperativity between the first and second binding of its substrate, CTP. Using NMR to study the allosteric mechanism of this enzyme, we observe widesprea
Autor:
Rowena G. Matthews, Craig W. Vander Kooi, Chad N. Stasik, Shawn Y. Stevens, Erik R. P. Zuiderweg, Diane A. Hall
Publikováno v:
Proceedings of the National Academy of Sciences. 98:9521-9526
Flavodoxins are electron-transfer proteins that contain the prosthetic group flavin mononucleotide. In Escherichia coli , flavodoxin is reduced by the FAD-containing protein NADPH:ferredoxin (flavodoxin) oxidoreductase; flavodoxins serve as electron
Autor:
Erik R. P. Zuiderweg, H P Feng, Shawn Y. Stevens, Diana L. Montgomery, C W Vander Kooi, Maurizio Pellecchia, Lila M. Gierasch
Publikováno v:
Nature Structural Biology. 7:298-303
How substrate affinity is modulated by nucleotide binding remains a fundamental, unanswered question in the study of 70 kDa heat shock protein (Hsp70) molecular chaperones. We find here that the Escherichia coli Hsp70, DnaK, lacking the entire alpha-