Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Shawn Winer"'
Autor:
Fei Wu, Huixun Du, Eliah Overbey, JangKeun Kim, Priya Makhijani, Nicolas Martin, Chad A. Lerner, Khiem Nguyen, Jordan Baechle, Taylor R. Valentino, Matias Fuentealba, Juliet M. Bartleson, Heather Halaweh, Shawn Winer, Cem Meydan, Francine Garrett-Bakelman, Nazish Sayed, Simon Melov, Masafumi Muratani, Akos A. Gerencser, Herbert G. Kasler, Afshin Beheshti, Christopher E. Mason, David Furman, Daniel A. Winer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated micrograv
Externí odkaz:
https://doaj.org/article/c7dca3abd2b846df8c5d5d597731d0e9
Autor:
Alexis Bretin, Jun Zou, Beng San Yeoh, Vu L. Ngo, Shawn Winer, Daniel A. Winer, Lavanya Reddivari, Michael Pellizzon, William A. Walters, Andrew D. Patterson, Ruth Ley, Benoit Chassaing, Matam Vijay-Kumar, Andrew T. Gewirtz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1421-1442 (2023)
Background & Aims: Fiber-rich foods promote health, but mechanisms by which they do so remain poorly defined. Screening fiber types, in mice, revealed psyllium had unique ability to ameliorate 2 chronic inflammatory states, namely, metabolic syndrome
Externí odkaz:
https://doaj.org/article/b450f87359d34bd3a652ed5fa80e4482
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101755- (2023)
Background: Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, the low-grade chronic inflammation during aging, without overt infection, is defined as “inflammaging,
Externí odkaz:
https://doaj.org/article/8d4feb75170e4081b40a011c98f7fc81
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
At the centre of intestinal health and the fight against obesity and metabolic syndrome is the intestinal microbiota and its interaction with our immune systems. Here the authors Review the current understanding of how these systems interact and how
Externí odkaz:
https://doaj.org/article/2fa522287a3e4d3bbeaf913131d03261
Autor:
Helen Luck, Saad Khan, Justin H. Kim, Julia K. Copeland, Xavier S. Revelo, Sue Tsai, Mainak Chakraborty, Kathleen Cheng, Yi Tao Chan, Mark K. Nøhr, Xavier Clemente-Casares, Marie-Christine Perry, Magar Ghazarian, Helena Lei, Yi-Hsuan Lin, Bryan Coburn, Allan Okrainec, Timothy Jackson, Susan Poutanen, Herbert Gaisano, Johane P. Allard, David S. Guttman, Margaret E. Conner, Shawn Winer, Daniel A. Winer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions
Externí odkaz:
https://doaj.org/article/da441e250e21423db8dd1a9346ba29eb
Autor:
Mainak Chakraborty, Kevin Chu, Annie Shrestha, Xavier S. Revelo, Xiangyue Zhang, Matthew J. Gold, Saad Khan, Megan Lee, Camille Huang, Masoud Akbari, Fanta Barrow, Yi Tao Chan, Helena Lei, Nicholas K. Kotoulas, Juan Jovel, Chiara Pastrello, Max Kotlyar, Cynthia Goh, Evangelos Michelakis, Xavier Clemente-Casares, Pamela S. Ohashi, Edgar G. Engleman, Shawn Winer, Igor Jurisica, Sue Tsai, Daniel A. Winer
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108609- (2021)
Summary: Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly understood. Here, we show that static tension impacts immune cell function, maturation, a
Externí odkaz:
https://doaj.org/article/2bdc05ee448647c1a7a0d51fb5a28476
Autor:
Xavier S. Revelo, Magar Ghazarian, Melissa Hui Yen Chng, Helen Luck, Justin H. Kim, Kejing Zeng, Sally Y. Shi, Sue Tsai, Helena Lei, Justin Kenkel, Chih Long Liu, Stephanie Tangsombatvisit, Hubert Tsui, Corneliu Sima, Changting Xiao, Lei Shen, Xiaoying Li, Tianru Jin, Gary F. Lewis, Minna Woo, Paul J. Utz, Michael Glogauer, Edgar Engleman, Shawn Winer, Daniel A. Winer
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 717-730 (2016)
Obesity-related inflammation of metabolic tissues, including visceral adipose tissue (VAT) and liver, are key factors in the development of insulin resistance (IR), though many of the contributing mechanisms remain unclear. We show that nucleic-acid-
Externí odkaz:
https://doaj.org/article/ce5351ca2ec04a7eba5603df62077ae4
Autor:
Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, Muhammed A. Rahman, Shawn Winer, Daniel A. Winer, Catherine J. Streutker, Dana J. Philpott, Stephen E. Girardin
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2576-2586 (2016)
The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal epithelial cells (IEC)-specific deletion of Nlrx1, we find that NLRX1 provides an IEC-in
Externí odkaz:
https://doaj.org/article/0516d2ca8656408cab832e57131bf2ae
Autor:
Geoffrey Paltser, Xue Jun Liu, Jason Yantha, Shawn Winer, Hubert Tsui, Ping Wu, Yuko Maezawa, Lindsay S. Cahill, Christine L. Laliberté, Sreeram V. Ramagopalan, Gabriele C. DeLuca, A. Dessa Sadovnick, Igor Astsaturov, George C. Ebers, R. Mark Henkelman, Michael W. Salter, H.-Michael Dosch
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 149-159 (2013)
Abstract Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) expressed in a major sensory neu
Externí odkaz:
https://doaj.org/article/e5890ad622bf4df7ba2d1d634ebcb2de
Autor:
Mario A. Moscarello, Helena Lei, Fabrizio G. Mastronardi, Shawn Winer, Hubert Tsui, Zhen Li, Cameron Ackerley, Li Zhang, Reinout Raijmakers, D. Denise Wood
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 467-478 (2013)
SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. We first discovered that abnormal myelin hypercitrullination, even in normal-
Externí odkaz:
https://doaj.org/article/052516e6eaf64f689ce3f8bd985d6515