Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shawn T. Beug"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-13 (2024)
Abstract Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in NF-κB signaling. The combination of SMCs with immunotherapies
Externí odkaz:
https://doaj.org/article/e7dfa93325ff4ad39a2ad7f101b6277c
Autor:
Arya Afsahi, Christopher M. Silvestri, Allyson E. Moore, Carly F. Graham, Kaylyn Bacchiochi, Martine St-Jean, Christopher L. Baker, Robert G. Korneluk, Shawn T. Beug, Eric C. LaCasse, Jonathan L. Bramson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe genesis of SMAC mimetic drugs is founded on the observation that many cancers amplify IAP proteins to facilitate their survival, and therefore removal of these pathways would re-sensitize the cells towards apoptosis. It has become incre
Externí odkaz:
https://doaj.org/article/eb5ca895b54b482fb6cf4a6da61045ce
Publikováno v:
Cells, Vol 12, Iss 20, p 2508 (2023)
Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated
Externí odkaz:
https://doaj.org/article/f604cad77eec4beabedfb4f84dcd0566
Autor:
Rostyslav Horbay, Ali Hamraghani, Leonardo Ermini, Sophie Holcik, Shawn T. Beug, Behzad Yeganeh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15317 (2022)
Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbatio
Externí odkaz:
https://doaj.org/article/546b333bb41b4c5599fb2dfbb3d883a5
Autor:
Shawn T. Beug, Stephanie J. Pichette, Martine St-Jean, Janelle Holbrook, Danielle E. Walker, Eric C. LaCasse, Robert G. Korneluk
Publikováno v:
Molecular Therapy: Oncolytics, Vol 10, Iss , Pp 28-39 (2018)
Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs syne
Externí odkaz:
https://doaj.org/article/c281d7e68df84c8fb966b20430c6a8ba
Publikováno v:
Cells, Vol 10, Iss 10, p 2672 (2021)
Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens. Unsurprisingly, this process becomes critical in supporting cellular
Externí odkaz:
https://doaj.org/article/999b098f42c74916b8d776825eba77e9
Autor:
Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer m
Externí odkaz:
https://doaj.org/article/153f1f0b72134cffba06e3aad0670491
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 4 (2019)
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert wi
Externí odkaz:
https://doaj.org/article/786c185c4b1746e197bb7199ee8e9d32
Autor:
Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 14278 (2017); Published 15 February 2017, Updated 18 July 2018 The original HTML version of this Article omitted the article number; it should have been ‘14278’. This has now been corrected in the HTML ver
Externí odkaz:
https://doaj.org/article/0b6566db7d48450a820918e98512a114
Autor:
Huy-Dung Hoang, Aida Said, Nasana Vaidya, Victoria H Gilchrist, Kyle Malone, Usha Kabilan, Serena Topshee, Xiao Xiang, An-Dao Yang, David Olagnier, Karen Mossman, Shawn T Beug, Seyed Mehdi Jafarnejad, Samuel T Workenhe, Tyson E Graber, Tommy Alain
Publikováno v:
Hoang, H-D, Said, A, Vaidya, N, Gilchrist, V H, Malone, K, Kabilan, U, Topshee, S, Xiang, X, Yang, A-D, Olagnier, D, Mossman, K, Beug, S T, Jafarnejad, S M, Workenhe, S T, Graber, T E & Alain, T 2023, ' Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1 ', Journal for Immunotherapy of Cancer, vol. 11, no. 3 . https://doi.org/10.1136/jitc-2022-006408
Hoang, H-D, Said, A, Vaidya, N, Gilchrist, V H, Malone, K, Kabilan, U, Topshee, S, Xiang, X, Yang, A-D, Olagnier, D, Mossman, K, Beug, S T, Jafarnejad, S M, Workenhe, S T, Graber, T E & Alain, T 2023, ' Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1 ', Journal for ImmunoTherapy of Cancer, vol. 11, no. 3, e006408 . https://doi.org/10.1136/jitc-2022-006408
Hoang, H-D, Said, A, Vaidya, N, Gilchrist, V H, Malone, K, Kabilan, U, Topshee, S, Xiang, X, Yang, A-D, Olagnier, D, Mossman, K, Beug, S T, Jafarnejad, S M, Workenhe, S T, Graber, T E & Alain, T 2023, ' Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1 ', Journal for ImmunoTherapy of Cancer, vol. 11, no. 3, e006408 . https://doi.org/10.1136/jitc-2022-006408
BackgroundTransgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db87106c07c6d4cb38cfe75b4d0ac4a9
https://pure.au.dk/portal/da/publications/adaptation-of-transgene-mrna-translation-boosts-the-anticancer-efficacy-of-oncolytic-hsv1(884e7668-3944-4cca-ac0e-6ef9a9c606d7).html
https://pure.au.dk/portal/da/publications/adaptation-of-transgene-mrna-translation-boosts-the-anticancer-efficacy-of-oncolytic-hsv1(884e7668-3944-4cca-ac0e-6ef9a9c606d7).html