Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shawn R. Feaster"'
Autor:
Greg E Garcia, G.Jean Kant, Richard A. Bauman, Sally M. Anderson, Shawn R. Feaster, George A. Saviolakis
Publikováno v:
Pharmacology Biochemistry and Behavior. 70:209-218
Thousands of soldiers who served in the Gulf War have symptoms that have been collectively termed Gulf War Illness (GWI). It has been suggested that a combination of operational stress and pyridostigmine, a drug given as a pretreatment to protect sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5177ada7e69ee5fbbaba58be047bc0d0
https://doi.org/10.1016/s0091-3057(01)00596-2
https://doi.org/10.1016/s0091-3057(01)00596-2
Autor:
Shawn R. Feaster, Nathan A. Baker, and Zoran Radić, Palmer Taylor, Haridasan K. Nair, Daniel M. Quinn
Publikováno v:
Journal of the American Chemical Society. 122:2975-2980
The quaternary ammonium binding locus in the active site of mammalian acetylcholinesterase is subtended by the side chains of Trp86, Tyr133, Glu202, and Tyr337. Linear free-energy relationships define the interactions involved in molecular recognitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cad902de70fdb0fbcba259a02c270f0
https://doi.org/10.1021/ja9933588
https://doi.org/10.1021/ja9933588
Autor:
Keith E. LeJeune, Shawn R. Feaster, Bhupendra P. Doctor, Michelle Ross, Alan J. Russell, David E. Lenz, Donald M. Maxwell, Richard K. Gordon
Publikováno v:
Chemico-Biological Interactions. :463-470
We previously demonstrated that a combination of cholinesterase (ChE) pre-treatment with an oxime is an effective measure against soman and sarin. We describe here a novel approach for the preparation of covalently linked ChEs which are immobilized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dd1361f80aedfee5b3dbb79a968217
https://doi.org/10.1016/s0009-2797(99)00059-9
https://doi.org/10.1016/s0009-2797(99)00059-9
Publikováno v:
Protein Science. 6:73-79
Structural models have been generated for rat and human cholesterol esterases by molecular modeling. For rat cholesterol esterase, three separate models were generated according to the following procedure: (1) the cholesterol esterase sequence was al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe5b1ed6d4359ed588219920ce4a621c
https://doi.org/10.1002/pro.5560060108
https://doi.org/10.1002/pro.5560060108
Publikováno v:
Journal of the American Chemical Society. 115:10477-10482
The mechanisms of acetylcholinesterase (AChE)-catalyzed hydrolyses of four choline esters, (acetylthio)choline, (propanoylthio)choline, (butanoylthio)choline, and benzoylcholine, have been compared by measuring relative activities and pH-rate effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65bbce987bacd14b2bf8e90255c16e13
https://doi.org/10.1021/ja00076a002
https://doi.org/10.1021/ja00076a002
Autor:
Keith E. LeJeune, Michelle Ross, Alan J. Russell, Patrick C. Herron, Richard K. Gordon, Erik R. Lowe, Shawn R. Feaster, David E. Lenz, Bhupendra P. Doctor
Publikováno v:
Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429
FBS-AChE and Equine-BChE were immobilized by covalently linking the enzymes to polyurethane foams (PUF), having the consistency of sponges. The enzymes attach to the inert foam at multiple points dependent upon the available free aliphatic amines (ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4971ec76fe84d83c00651a9e091dd3
https://doi.org/10.1007/978-1-4899-1540-5_89
https://doi.org/10.1007/978-1-4899-1540-5_89
Publikováno v:
Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429
Inasmuch as the traditional pharmacological approaches to protection against organophosphorus (OP) compounds may be near their practical limits, a new approach using enzymes as bioscavengers has recently been examined. The feasibility of using biosca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::862f9b69f804796b532c7bd5a4522c38
https://doi.org/10.1007/978-1-4899-1540-5_109
https://doi.org/10.1007/978-1-4899-1540-5_109
Autor:
Daniel M. Quinn, Shawn R. Feaster
Publisher Summary This chapter summarizes the various classes of cholesterol esterase (CEase) inhibitors and describes the methods for characterizing inhibition by carbamates. It outlines features of CEase structure and function that facilitate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5df9ea4052ef45deee832a76843dea89
https://doi.org/10.1016/s0076-6879(97)86013-2
https://doi.org/10.1016/s0076-6879(97)86013-2