The combined effects of pyridostigmine and chronic stress on brain cortical and blood acetylcholinesterase, corticosterone, prolactin and alternation performance in rats

Autor: Greg E Garcia, G.Jean Kant, Richard A. Bauman, Sally M. Anderson, Shawn R. Feaster, George A. Saviolakis

Publikováno v: Pharmacology Biochemistry and Behavior. 70:209-218

Thousands of soldiers who served in the Gulf War have symptoms that have been collectively termed Gulf War Illness (GWI). It has been suggested that a combination of operational stress and pyridostigmine, a drug given as a pretreatment to protect sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5177ada7e69ee5fbbaba58be047bc0d0
https://doi.org/10.1016/s0091-3057(01)00596-2

Organophosphate skin decontamination using immobilized enzymes

Autor: Keith E. LeJeune, Shawn R. Feaster, Bhupendra P. Doctor, Michelle Ross, Alan J. Russell, David E. Lenz, Donald M. Maxwell, Richard K. Gordon

Publikováno v: Chemico-Biological Interactions. :463-470

We previously demonstrated that a combination of cholinesterase (ChE) pre-treatment with an oxime is an effective measure against soman and sarin. We describe here a novel approach for the preparation of covalently linked ChEs which are immobilized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dd1361f80aedfee5b3dbb79a968217
https://doi.org/10.1016/s0009-2797(99)00059-9

Parallel mechanisms in acetylcholinesterase-catalyzed hydrolysis of choline esters

Autor: Daniel M. Quinn, Michael J. States, Shawn R. Feaster, Alton N. Pryor, Trevor Selwood

Publikováno v: Journal of the American Chemical Society. 115:10477-10482

The mechanisms of acetylcholinesterase (AChE)-catalyzed hydrolyses of four choline esters, (acetylthio)choline, (propanoylthio)choline, (butanoylthio)choline, and benzoylcholine, have been compared by measuring relative activities and pH-rate effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65bbce987bacd14b2bf8e90255c16e13
https://doi.org/10.1021/ja00076a002

Comparison of Cholinesterases and Carboxylesterase as Bioscavengers for Organophosphorus Compounds

Autor: Ashima Saxena, Shawn R. Feaster, Donald M. Maxwell, Bhupendra P. Doctor, Karen M. Brecht

Publikováno v: Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429

Inasmuch as the traditional pharmacological approaches to protection against organophosphorus (OP) compounds may be near their practical limits, a new approach using enzymes as bioscavengers has recently been examined. The feasibility of using biosca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::862f9b69f804796b532c7bd5a4522c38
https://doi.org/10.1007/978-1-4899-1540-5_109

WHOLE BLOOD ROBOTIC CHOLINESTERASE ASSAY FOR ORGANOPHOSPHATE EXPOSURE - TESTING SOLDIERS, FIRST RESPONDERS, AND CIVILIANS IN THE FIELD AND LABORATORY.

Autor: Gordon, Richard K., Haigh, Julian R., Garcia, Gregory E., Feaster, Shawn R., Doctor, Bhupendra P., Riel, Michael A., Lefkowitz, Lee J., Lenz, David E., Aisen, Paul S., Smart, Wilson

Publikováno v: Transformational Science & Technology For the Current & Future Force (With CD-ROM) - Proceedings of the 24th Us Army Science Conference; 2006, p401-408, 8p