Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shawn P. Walsh"'
Autor:
Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064
https://doi.org/10.1016/j.bmcl.2016.10.064
Autor:
Hong Liu, Shawn P. Walsh, Yan Qi, Jiaqiang Cai, Jack D. Scott, Xin-Jie Chu, Cuizhi Mu, Brandon M. Taoka, Yaxian Cai, Jinsong Hao, Quang Truong, Zhong Lai, Xing Dai, Wen-Lian Wu, Jeffrey T. Kuethe, Eric J. Gilbert, Andrew Brunskill, Jared N. Cumming
Publikováno v:
Tetrahedron. 72:6011-6020
A novel domino reaction for the preparation of non-racemic β-proline derivatives is reported. The addition of a methyl 2-(oxetan-3-yl)acetate titanium enolate to chiral tert-butanesulfinyl ketimines followed by an intramolecular oxetane ring-opening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f6ea7d457ba02cc5aae8322fdf057d3
https://doi.org/10.1016/j.tet.2016.08.017
https://doi.org/10.1016/j.tet.2016.08.017
Autor:
Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
Publikováno v:
ACS Medicinal Chemistry Letters. 7:697-701
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Because of this dual site of action, selective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122
https://doi.org/10.1021/acsmedchemlett.6b00122
Autor:
Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey
Publikováno v:
ACS Medicinal Chemistry Letters. 6:747-752
A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic properties across preclinical species support furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u
https://doi.org/10.1021/ml500440u
Autor:
Pamela K Carmines, Xiaoyan Zhou, Maya Dajee, Kathleen A Sullivan, Shawn P Walsh, Alexander Pasternak
Publikováno v:
Hypertension. 70
The bee venom toxin tertiapin Q (TPQ) evokes tubuloglomerular feedback-independent afferent arteriolar constriction in kidneys from rats with streptozotocin-induced type 1 diabetes (STZ rats). Because TPQ inhibits both Kir1.1 and Kir3.x channels, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7e71e68bc990232f1631f255d3a93e1
https://doi.org/10.1161/hyp.70.suppl_1.068
https://doi.org/10.1161/hyp.70.suppl_1.068
Autor:
Xiaoyan Zhou, Shawn P. Walsh, William J. Welch, Kathleen A. Sullivan, Magali Araujo, Alexander Pasternak, Christopher S. Wilcox
Publikováno v:
American journal of physiology. Renal physiology. 312(6)
The Na+-K+-2Cl−cotransporter (NKCC2) on the loop of Henle is the site of action of furosemide. Because outer medullary potassium channel (ROMK) inhibitors prevent reabsorption by NKCC2, we tested the hypothesis that ROMK inhibition with a novel sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12bc8f43d4a8431954de9f44f48bc93
https://pubmed.ncbi.nlm.nih.gov/28228405
https://pubmed.ncbi.nlm.nih.gov/28228405
Autor:
Yan Yan, Richard M. Brochu, Maria L. Garcia, Lihu Yang, Sophie Roy, Gregory J. Kaczorowski, Reynald K. de Jesus, Birgit T. Priest, Xiaoyan Zhou, Lee-Yuh Pai, Shawn P. Walsh, Yuping Zhu, Karen Owens, Caryn Hampton, Timothy Bailey, Andrew M. Swensen, Brande Thomas-Fowlkes, Magdalena Alonso-Galicia, John P. Felix, Melba Hernandez, Alexander Pasternak, Haifeng Tang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5829-5832
A sub-class of distinct small molecule ROMK inhibitors were developed from the original lead 1. Medicinal chemistry endeavors led to novel ROMK inhibitors with good ROMK functional potency and improved hERG selectivity. Two of the described ROMK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5c348f365905a62caacd72f218a844
https://doi.org/10.1016/j.bmcl.2013.08.104
https://doi.org/10.1016/j.bmcl.2013.08.104
Autor:
Xiaoyan Zhou, Maya Dajee, Michael J. Forrest, Gail Forrest, Sloan Stribling, Andra S. Stevenson, Shawn P. Walsh, Kathleen A. Sullivan, Yonghua Zhu, Wanda Sharif-Rodriguez, Daphne Szeto, Alexander Pasternak, Yuchen Zhou, Olga Urosevic-Price
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 69(2)
The renal outer medullary potassium (ROMK) channel mediates potassium recycling and facilitates sodium reabsorption through the Na + /K + /2Cl − cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Evidence fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef4fb2fe814ea53e893f31d9be23ca
https://pubmed.ncbi.nlm.nih.gov/27920129
https://pubmed.ncbi.nlm.nih.gov/27920129
Autor:
Shawn P. Walsh, Jessica Frie, Nardos Teumelsan, Maria L. Garcia, Karen Owens, Sophie Roy, Caryn Hampton, Reynalda K. de Jesus, Birgit T. Priest, Magdalena Alonso-Galicia, Aurash Shahripour, Richard M. Brochu, Juliann Ehrhart, Andrew M. Swensen, Haifeng Tang, Timothy Bailey, Alexander Pasternak, Lee-Yuh Pai, Yuping Zhu, Lihu Yang, Gregory J. Kaczorowski, John P. Felix, Melba Hernandez, Brande Thomas-Fowlkes, Xiaoyan Zhou
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(9)
Following the discovery of small molecule acyl piperazine ROMK inhibitors and their initial preclinical validation as a novel diuretic agent, our group set out to discover new ROMK inhibitors with reduced risk for QT effects, suitable for further pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fbe8f6e22893cf2f312c30961b9cd2
https://pubmed.ncbi.nlm.nih.gov/27017115
https://pubmed.ncbi.nlm.nih.gov/27017115
Autor:
Min Shu, William J. Greenlee, Alan Hruza, Harold B. Wood, Min Park, Shawn P. Walsh, Kenneth P. Ellsworth, Yi-Heng Chen, Lisa M. Sonatore, Bart Harper, Bing Li, Aurash Sharipour, Richard A. Berger, Cameron J. Smith, Esther Kim, Edward C. Sherer, Paul Reichert, Jane Y. Wu, Wayne M. Geissler, Jiayi Xu, Sunita V. Dewnani, James M. Balkovec, Dann L. Parker, Ting Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(11)
Two high-throughput screening hits were investigated for SAR against human factor IXa. Both hits feature a benzamide linked to a [6-5]-heteroaryl via an alkyl amine. In the case where this system is a benzimidazolyl-ethyl amine the binding potency fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6383cff65e1e05696a8b9c62363937ea
https://pubmed.ncbi.nlm.nih.gov/25937013
https://pubmed.ncbi.nlm.nih.gov/25937013