Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shawn P. Fessler"'
Publikováno v:
Cancer Research. 82:1756-1756
Introduction: XMT-1660 is a first-in-class Dolasynthen Antibody-Drug Conjugate (ADC) targeting B7-H4 and carrying a DolaLock payload with controlled bystander effect. B7-H4 is an immunoregulatory protein that is expressed in breast, ovarian and endom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b4e8ef4af89387fd2407a5410e1065d
https://doi.org/10.1158/1538-7445.am2022-1756
https://doi.org/10.1158/1538-7445.am2022-1756
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2054 (2008)
The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells. However, a mechanistic link between aberrant expression and cancer
Externí odkaz:
https://doaj.org/article/6b598745533848638598ca09c5bdce3e
Autor:
Scott D. Collins, Kelly Slocum, Jason K. Wang, Dorin Toader, Ling Xu, Elizabeth Ditty, Chen-Ni Chin, Anouk Dirksen, Marc Damelin, Steven Vonderfecht, Rebecca Mosher, Dokyong Kim, Jeffrey Zurita, Susan M. Clardy, Kenneth Avocetien, Ronald Eydelloth, Timothy B. Lowinger, LiuLiang Qin, Bingfan Du, Steven Bradley, Shawn P. Fessler, Phonphimon Wongthida, Alex Uttard, Elena Ter-Ovanesyen
Publikováno v:
Cancer Research. 81:907-907
XMT-1660 is a novel Dolasynthen-based antibody drug conjugate carrying a DolaLock payload with controlled bystander effect and targeting B7-H4, a tumor antigen that is broadly expressed on the cell surface in breast, ovarian and endometrial cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2807e2ea7c8be1c11fb15f3c7dc8f0
https://doi.org/10.1158/1538-7445.am2021-907
https://doi.org/10.1158/1538-7445.am2021-907
Autor:
Jack L. Strominger, Laura Santambrogio, Siew Heng Wong, Shawn P. Fessler, Graça Raposo, Ilaria Potolicchio
Publikováno v:
Nature Immunology. 6:1020-1028
The involvement of the tetrameric adaptor protein 1 (AP-1) complex in protein sorting in intracellular compartments is not yet completely defined. Here we report that in immature dendritic cells, the beta1- and gamma-subunits of AP-1 underwent caspas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efb885b27ab9e7ea5df9126c569aea9
https://doi.org/10.1038/ni1250
https://doi.org/10.1038/ni1250
Autor:
C.S.H. Young, Shawn P. Fessler
Publikováno v:
Virology. 263:507-516
The late phase of adenovirus infection is characterized not only by the synthesis of late proteins and the assembly of new virions, but also by the inhibition of early gene expression and host cell translation. Previous work has demonstrated that bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b010cdf227873da52f9bd7528aeb06
https://doi.org/10.1006/viro.1999.9951
https://doi.org/10.1006/viro.1999.9951
Autor:
C.S.H. Young, Shawn P. Fessler
Publikováno v:
Journal of Virology. 72:4049-4056
The adenovirus gene regulatory program occurs in two distinct phases, as defined by the onset of DNA replication. During the early phase, the E1A, E1B, E2, E3, and E4 genes are maximally expressed, while the major late promoter (MLP) is minimally exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a116a39040400518d2461cc214274d
https://doi.org/10.1128/jvi.72.5.4049-4056.1998
https://doi.org/10.1128/jvi.72.5.4049-4056.1998
v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5′-phosphatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677b46015145bd66f486a5d932a003da
https://europepmc.org/articles/PMC3165847/
https://europepmc.org/articles/PMC3165847/
Publikováno v:
Breast cancer research and treatment. 118(1)
In the United States, 211,000 women are diagnosed each year with breast cancer. Of the 42,000 breast cancer patients who overexpress the HER2 growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2006a6e1cb89a2d217bf439d33ba973
https://pubmed.ncbi.nlm.nih.gov/19834800
https://pubmed.ncbi.nlm.nih.gov/19834800
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2054 (2008)
PLoS ONE
PLoS ONE
The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells. However, a mechanistic link between aberrant expression and cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69031dac83045912fd94e31ccddc67c
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18446242/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18446242/?tool=EBI