Výsledky vyhledávání - "Shawn P. Fahl"

Abstract 602: Single cell evaluation of intratumoral B cells across solid tumor indications

Autor: Shawn P. Fahl, Kerri Colwell, Casey Smith, Cavin Ott, Alex Moore, Kayla Williams

Publikováno v: Cancer Research. 83:602-602

The immune system is a critical component of the tumor microenvironment that has both tumor-promoting and tumor-eradicating activity based on the specific immune cell subtype and their activation status. T lymphocytes represent the largest lymphocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7ec64dcd6b3d1ebc391fd3ff66b3bad
https://doi.org/10.1158/1538-7445.am2023-602

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The ERK2 DBP domain opposes pathogenesis of a JAK2V617F-driven myeloproliferative neoplasm

Autor: Yong Zhang, Billy Truong, Shawn P Fahl, Esteban Martinez, Kathy Cai, Essel Dulaimi, Yulan Gong, Dan A. Liebermann, Jonathan Soboloff, Roland Dunbrack, Ross L. Levine, Steven Fletcher, Dietmar J. Kappes, Stephen Sykes, Paul Shapiro, David L Wiest

Publikováno v: Blood.

While Ras/mitogen-activated protein kinase (MAPK) signaling is activated in most human cancers, attempts to target this pathway using kinase active site inhibitors have not typically led to durable, clinical benefit. To address this shortcoming, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ab8dee649a03cc8d234ea9362d3d61
https://doi.org/10.1182/blood.2021013068

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Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis

Autor: Shawn P. Fahl, Robert Sertori, Yong Zhang, Alejandra V. Contreras, Bryan Harris, Minshi Wang, Jacqueline Perrigoue, Siddharth Balachandran, Brian K. Kennedy, David L. Wiest

Publikováno v: J Immunol

Ribosomal proteins are thought to primarily facilitate biogenesis of the ribosome and its ability to synthesize protein. However, in this study, we show that Rpl22-like1 (Rpl22l1) regulates hematopoiesis without affecting ribosome biogenesis or bulk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8684d7dc6004ad64165d15e21f97a520
https://pubmed.ncbi.nlm.nih.gov/35046107

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The E protein-TCF1 axis controls γδ T cell development and effector fate

Autor: David L. Wiest, Christelle Harly, Juan Carlos Zúñiga-Pflücker, Anjali Verma, Jyoti Misra Sen, Shawn P. Fahl, Cornelis Murre, Freddy Radtke, Alejandra V. Contreras, Xiang Qiu, Hai-Hui Xue

Publikováno v: Cell reports
Cell Reports
Cell Reports, 2021, 34 (5), pp.108716. ⟨10.1016/j.celrep.2021.108716⟩

SUMMARY TCF1 plays a critical role in T lineage commitment and the development of αβ lineage T cells, but its role in γδ T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa759a7e601661e18aaf8eb330deab5
https://pubmed.ncbi.nlm.nih.gov/33535043

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Role of a selecting ligand in shaping the murine γδ-TCR repertoire

Autor: Lisa Kain, Juan Carlos Zúñiga-Pflücker, David L. Wiest, Roland L. Dunbrack, Francis Coffey, Payam Zarin, Luc Teyton, Shawn P. Fahl, Dietmar J. Kappes

Publikováno v: Proceedings of the National Academy of Sciences. 115:1889-1894

Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0402393808d5429d22805191179921
https://doi.org/10.1073/pnas.1718328115

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ERK2 Substrate Binding Domains Perform Opposing Roles in Pathogenesis of a JAK2V617F-Driven Myeloproliferative Neoplasm

Autor: Billy Truong, David L. Wiest, Esteban Martínez, Shawn P. Fahl, Dietmar J. Kappes, Ross L. Levine, Yong Zhang, Dan A. Liebermann, Jonathan Soboloff, Stephen M. Sykes, Paul Shapiro, Roland L. Dunbrack, Kathy Q. Cai, Yulan Gong, Essel Dulaimi Al-Saleem

Publikováno v: Blood. 138:2547-2547

The interaction between ERK2 and its substrates is critically mediated by two domains, the common docking (CD) D-domain and DEF-binding pocket (DBP) domain. Previous studies have suggested that ERK2 is not only necessary to drive hematopoietic and my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c1fa72ab48a2de245488f8506eddaf1
https://doi.org/10.1182/blood-2021-152063

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Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma

Autor: Noa Greenberg-Kushnir, Kathy Q. Cai, Nehal Solanki-Patel, Shawn P. Fahl, Shuyun Rao, Sang-Yun Lee, Joseph R. Testa, David L. Wiest, Jason Stadanlick

Publikováno v: Cancer Research. 76:3387-3396

Mutations in ribosomal proteins cause bone marrow failure syndromes associated with increased cancer risk, but the basis by which they do so remains unclear. We reported previously that the ribosomal protein Rpl22 is a tumor suppressor in T-cell acut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5887401e8fdbda4cc39061481371e271
https://doi.org/10.1158/0008-5472.can-15-2698

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