Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shawn P. Alter"'
Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice
Autor:
Amy R. Dunn, Thomas S. Guillot, Kelly M. Lohr, Kristen A. Stout, Rachel A. Cliburn, Shawn P. Alter, Gary W. Miller
Publikováno v:
ACS Chemical Neuroscience
Drugs of abuse induce sensitization, which is defined as enhanced response to additional drug following a period of withdrawal. Sensitization occurs in both humans and animal models of drug reinforcement and contributes substantially to the addictive
Autor:
Xueliang Fan, Alison I. Bernstein, Gary W. Miller, Yingjie Li, Kristen A. Stout, Thomas S. Guillot, Minzheng Wang, Laura M. Vecchio, Carlos R. Lazo, Ellen J. Hess, Shawn P. Alter, Amy R. Dunn, Hong Yi, Kelly M. Lohr, Ali Salahpour, David S. Goldstein
Publikováno v:
Proceedings of the National Academy of Sciences. 111:9977-9982
Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric conditions. Here, we report a novel mouse model of enhanced vesicular function via bacterial art
Publikováno v:
Neuropharmacology. 76:97-105
Parkinson's disease (PD) is the most common neurodegenerative motor disease. Pathologically, PD is characterized by Lewy body deposition and subsequent death of dopamine neurons in the substantia nigra pars compacta. PD also consistently features deg
Autor:
Wen Mei Yu, Olgun Guvench, Mignon L. Loh, Li Da Tang, Wei Liu, Cheng-Kui Qu, Alexander D. MacKerell, Bing Yu, Shawn P. Alter
Publikováno v:
Molecular Cancer Therapeutics. 12:1738-1748
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of Noonan syndrome and childhood leukemias
The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity
Publikováno v:
Journal of Biological Chemistry. 286:28914-28921
GPR56 is an adhesion G protein-coupled receptor that plays a key role in cortical development. Mutations to GPR56 in humans cause malformations of the cerebral cortex, but little is known about the normal function of the receptor. We found that the l
Autor:
Thomas S. Guillot, Kristen A. Stout, Kennie R. Shepherd, Tonya N. Taylor, Gary W. Miller, Minzheng Wang, Shawn P. Alter, Kelly M. Lohr
We previously demonstrated that mice with reduced expression of the vesicular monoamine transporter 2 (VMAT2 LO) undergo age-related degeneration of the catecholamine-producing neurons of the substantia nigra pars compacta and locus ceruleus and exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb91343389c27e50dd29519a06105ba
https://europepmc.org/articles/PMC4793730/
https://europepmc.org/articles/PMC4793730/
Autor:
Courtney Holmes, Randy Strong, Patti Sullivan, Deborah C. Mash, Irwin J. Kopin, Yehonatan Sharabi, David S. Goldstein, Gary W. Miller, Shawn P. Alter
Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is toxic. According to the ‘catecholaldehyde hypothesis,’ DOPAL destroys nigrostriatal DA terminals and contributes to the profoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f949b433757fe1966d8270b6ce7428
https://europepmc.org/articles/PMC4096629/
https://europepmc.org/articles/PMC4096629/
Publikováno v:
Current Neurology and Neuroscience Reports. 13
The defining motor characteristics of Parkinson’s disease (PD) are mediated by the neurotransmitter dopamine (DA). Dopamine molecules spend most of their lifespan stored in intracellular vesicles awaiting release and very little time in the extrace
Publikováno v:
The FASEB Journal. 22