Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Shawn P Iadonato"'
Autor:
Ikenna G Madu, Megan Files, Dima N Gharaibeh, Amy L Moore, Kie-Hoon Jung, Brian B Gowen, Dongcheng Dai, Kevin F Jones, Shanthakumar R Tyavanagimatt, James R Burgeson, Marcus J Korth, Kristin M Bedard, Shawn P Iadonato, Sean M Amberg
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Autor:
Eric J Tarcha, Chelsea M Olsen, Peter Probst, David Peckham, Ernesto J Muñoz-Elías, James G Kruger, Shawn P Iadonato
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180762 (2017)
Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases,
Externí odkaz:
https://doaj.org/article/f137890bf7c24d3ebf96fb3d4a62b3ef
Autor:
Lucas L Lintermans, Coen A Stegeman, Ernesto J Muñoz-Elías, Eric J Tarcha, Shawn P Iadonato, Abraham Rutgers, Peter Heeringa, Wayel H Abdulahad
Publikováno v:
Rheumatology.
Objectives Granulomatosis with polyangiitis (GPA) is a chronic relapsing systemic autoimmune vasculitis. Current treatment of GPA is unsatisfactory, as it relies on strong immunosuppressive regimens, with either CYC or rituximab, which reduce the imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e83735e6da52265479d48ceabc6b4705
https://doi.org/10.1093/rheumatology/kead192
https://doi.org/10.1093/rheumatology/kead192
Autor:
Thierry Guillaudeux, Yulia Ovechkina, Eric J. Tarcha, David Jurchen, Shawn P. Iadonato, David Peckham, Emily Frazier, Shaarwari Sridhar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCD27 is a member of the TNF receptor superfamily and plays a critical role in T-cell activation by providing a costimulatory signal. CD27 signaling enhances T-cell proliferation, activation and differentiation of effector and memory T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e8b0489beeed0ddf703e5321ee2f4
https://doaj.org/article/4790c3f21dfb4f7ca6e878ba872663fa
https://doaj.org/article/4790c3f21dfb4f7ca6e878ba872663fa
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A291-A291
BackgroundV-domain Ig Suppressor of T cell Activation (VISTA) is an immune-suppressive checkpoint inhibitor of T cell response. VISTA is expressed in the immuno-suppressive tumor microenvironment, mostly by cells of the myeloid lineage, and its block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d7ba7240c2849a6c6e7967240b2c24
https://doi.org/10.1136/jitc-2021-sitc2021.268
https://doi.org/10.1136/jitc-2021-sitc2021.268
Autor:
R. Lance, D. Peckham, B. Dutzar, E. Frazier, D. Jurchen, Y. Ovechkina, T. Guillaudeux, M. Xu, C. Loomis, S. Sridhar, Eric J. Tarcha, N. Eyde, R. Bader, K. Lustig, Shawn P. Iadonato, Posakony Jeffrey J
Publikováno v:
Annals of Oncology. 31:S1448-S1449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91c318582f1ba7b8afe26b7f2a3049f
https://doi.org/10.1016/j.annonc.2020.10.564
https://doi.org/10.1016/j.annonc.2020.10.564
Autor:
Benjamin H. Dutzar, Robert Bader, Cristina Moldovan Loomis, Yulia Ovechkina, Shawn P. Iadonato, Remington Lance, David Peckham, Emily Frazier, Shaarwari Sridhar, Nathan Eyde, David Jurchen, Jeff Posakony, Mei Xu, Kurt Lustig, Thierry Guillaudeux, Eric J. Tarcha
Publikováno v:
Cancer Research. 81:1637-1637
V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is an immune checkpoint regulator of the B7 family. VISTA can be found on the cell surface of some tumor types, however for the majority of cancers, VISTA is highly expressed in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee702bca20eca3a99485a9ca6c51c69
https://doi.org/10.1158/1538-7445.am2021-1637
https://doi.org/10.1158/1538-7445.am2021-1637
Autor:
Ernesto J. Munoz, Kristin Bedard, John B. Grigg, Peter Probst, Myra L. Wang, Michael Gale, Shawn P. Iadonato, Yueh Ming Loo, Renee C. Ireton
Publikováno v:
Vaccine. 35:1964-1971
Vaccine adjuvants are essential to drive a protective immune response in cases where vaccine antigens are weakly immunogenic, where vaccine antigen is limited, or where an increase in potency is needed for a specific population, such as the elderly.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403a773a79269188407cb51a19203648
https://doi.org/10.1016/j.vaccine.2017.01.053
https://doi.org/10.1016/j.vaccine.2017.01.053
Autor:
James R. Burgeson, Kristin Bedard, Sean M. Amberg, Megan Files, Kevin F. Jones, Shawn P. Iadonato, Marcus J. Korth, Dima N. Gharaibeh, Dongcheng Dai, Amy L. Moore, Ikenna G. Madu, Shanthakumar R. Tyavanagimatt, Kieh-Hoon Jung, Brian B. Gowen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
PLoS Pathogens
Animal, Dairy, and Veterinary Science Faculty Publications
PLoS Pathogens
Animal, Dairy, and Veterinary Science Faculty Publications
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfd2114900d28a5cf2d40cc650d80a8
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Autor:
Jeff Posakony, Thierry Guillaudeux, Robert Bader, Kurt Lustig, Remington Lance, Shawn P. Iadonato, Emily Frazier, Mei Xu, David Peckham, Benjamin H. Dutzar, Shaarwari Sridhar, Eric J. Tarcha, Nathan Eyde, Yulia Ovechkina, Cristina Moldovan Loomis, David Jurchen
Publikováno v:
Cancer Immunology Research. 9:PR005-PR005
V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family ligand expressed on circulating and intratumoural myeloid cells as well as Treg and NK cells. It has been shown to inhibit T cell responses in vitro and in preclinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a2f8cd7cd450498892c61ad923317dc
https://doi.org/10.1158/2326-6074.tumimm20-pr005
https://doi.org/10.1158/2326-6074.tumimm20-pr005