Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shawn P Driscoll"'
Autor:
Matthew J Sternfeld, Christopher A Hinckley, Niall J Moore, Matthew T Pankratz, Kathryn L Hilde, Shawn P Driscoll, Marito Hayashi, Neal D Amin, Dario Bonanomi, Wesley D Gifford, Kamal Sharma, Martyn Goulding, Samuel L Pfaff
Publikováno v:
eLife, Vol 6 (2017)
Flexible neural networks, such as the interconnected spinal neurons that control distinct motor actions, can switch their activity to produce different behaviors. Both excitatory (E) and inhibitory (I) spinal neurons are necessary for motor behavior,
Externí odkaz:
https://doaj.org/article/10ac875644e74cddb906b2d1a978f50c
Autor:
Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Shawn P. Driscoll, Thomas D. Glenn, Samuel L. Pfaff, Joseph D. Ciacci, Martin Marsala
Publikováno v:
Cell Transplantation, Vol 32 (2023)
One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cell-treatment products for patient administration. Besi
Externí odkaz:
https://doaj.org/article/53f0f5b81b344c76bd490c0f787e3315
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101130- (2022)
Summary: microRNAs (miRNAs) have unique gene regulatory effects in different neuronal subpopulations. Here, we describe a protocol to identify neuronal subtype-specific effects of a miRNA in murine motor neuron subpopulations. We detail the preparati
Externí odkaz:
https://doaj.org/article/39dcae4fa90e46eb89090c1f00ffda7f
Autor:
Dasa Bohaciakova, Marian Hruska-Plochan, Rachel Tsunemoto, Wesley D. Gifford, Shawn P. Driscoll, Thomas D. Glenn, Stephanie Wu, Silvia Marsala, Michael Navarro, Takahiro Tadokoro, Stefan Juhas, Jana Juhasova, Oleksandr Platoshyn, David Piper, Vickie Sheckler, Dara Ditsworth, Samuel L. Pfaff, Martin Marsala
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background A well-characterized method has not yet been established to reproducibly, efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem cells (hNSCs) from embryonic stem cells (hESCs). Consequently,
Externí odkaz:
https://doaj.org/article/f87a5d79962b40ba83ca9d1341131d90
Autor:
Takahiro Tadokoro, Mariana Bravo-Hernandez, Kirill Agashkov, Yoshiomi Kobayashi, Oleksandr Platoshyn, Michael Navarro, Silvia Marsala, Atsushi Miyanohara, Tetsuya Yoshizumi, Michiko Shigyo, Volodymyr Krotov, Stefan Juhas, Jana Juhasova, Duong Nguyen, Helena Kupcova Skalnikova, Jan Motlik, Hana Studenovska, Vladimir Proks, Rajiv Reddy, Shawn P. Driscoll, Thomas D. Glenn, Taratorn Kemthong, Suchinda Malaivijitnond, Zoltan Tomori, Ivo Vanicky, Manabu Kakinohana, Samuel L. Pfaff, Joseph Ciacci, Pavel Belan, Martin Marsala
Publikováno v:
Molecular Therapy. 30:2722-2745
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of pain signals to the brain. Exogenously induced change in developmentally imprinted excitatory neurotransmitter phenotypes of these neurons to inhibit
Autor:
Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Shawn P. Driscoll, Thomas D. Glenn, Samuel L. Pfaff, Joseph D. Ciacci, Martin Marsala
One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cell-treatment products for patient administration. Besi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b9ecf3ac1d23b186656c93e245919d
https://escholarship.org/uc/item/6sx7k61r
https://escholarship.org/uc/item/6sx7k61r
Autor:
Peter J. Osseward, Bianca K. Barriga, Marito Hayashi, Lukas C. Bachmann, Jeffrey D. Moore, Robert C. Clark, Miriam Gullo, Samuel L. Pfaff, Fernando Beltran, Shawn P. Driscoll, Neal D. Amin, Benjamin A. Temple
Publikováno v:
Science
Motor and sensory functions of the spinal cord are mediated by populations of cardinal neurons arising from separate progenitor lineages. However, each cardinal class is composed of multiple neuronal types with distinct molecular, anatomical, and phy
Autor:
Noe Govea-Perez, Zoltán Tomori, Atsushi Miyanohara, PeiXi Chen, Mariana Bravo-Hernández, Wenlian Zhu, Joseph D. Ciacci, Brian K. Kaspar, Dara Ditsworth, Melissa McAlonis-Downes, Thomas D. Glenn, Oleksandr Platoshyn, Vladimír Proks, Samuel L. Pfaff, Stefan Juhas, Don W. Cleveland, Sandrine Da Cruz, Michael R. Navarro, Jana Juhasova, Eric T. Ahrens, Helena Kupcova Skalnikova, Ivo Vanicky, Hana Studenovská, Takahiro Tadokoro, Martin Marsala, Yoshiomi Kobayashi, Shawn P. Driscoll, Silvia Marsala, Shang Gao
Publikováno v:
Nat Med
Nature medicine, vol 26, iss 1
Nature medicine, vol 26, iss 1
Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherited neurodegenerative disorders. In the present study we develop a subpial technique, which we show in adult animals successfully delivers adeno-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d6e6d341c49955c92f1d93ffac3ebe
https://europepmc.org/articles/PMC8171115/
https://europepmc.org/articles/PMC8171115/
Autor:
Bridget Kohlnhofer, Andy Chen, Nady El Hajj, Hong Sook Kim, Carlos Mackintosh, Angels Almenar-Queralt, Takahiro Tadokoro, Jessica E. Young, Marian Hruska-Plochan, Catarina Allegue, Lawrence S.B. Goldstein, Michael Navarro, Martin Marsala, Shawn P. Driscoll, Daria Merkurjev, Lauren K. Fong, Dáša Bohačiaková, Grace Woodruff, Ivan Garcia-Bassets, Marcus Dittrich, Qi Ma, Rodrigo S. Chaves
Publikováno v:
Nature genetics, vol 51, iss 12
Nature genetics
Nature genetics
In the mammalian genome, the clustered protocadherin (cPcdh) locus is a paradigm of stochastic gene expression with the potential to generate a unique cPcdh combination in every neuron. Here, we report a chromatin-based mechanism emerging during the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c627768826ace87b72b2351f09ccf93
https://escholarship.org/uc/item/6s76w8n5
https://escholarship.org/uc/item/6s76w8n5
Autor:
Brendan O'Leary, Shawn P. Driscoll, Giancarlo Costaguta, Dario Bonanomi, Neal D. Amin, Samuel L. Pfaff, Gokhan Senturk
Publikováno v:
Neuron. 109:3252-3267.e6
Summary Disruption of homeostatic microRNA (miRNA) expression levels is known to cause human neuropathology. However, the gene regulatory and phenotypic effects of altering a miRNA’s in vivo abundance (rather than its binary gain or loss) are not w