Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shawn Misialek"'
Autor:
Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The current paradigm for the treatment of chronic hepatitis C virus (HCV) infection involves combinations of agents that act directly on steps of the HCV life cycle. Here we report the preclinical characteristics of ITMN-8187, a nonmacrocyclic inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e526d623aa25a82e039d51bfe79da1d8
https://doi.org/10.1128/aac.01569-16
https://doi.org/10.1128/aac.01569-16
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, Richard John Mears
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4480-4483
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ef0a9262fe818849b255d0368b7bd
https://doi.org/10.1016/j.bmcl.2009.05.022
https://doi.org/10.1016/j.bmcl.2009.05.022
Autor:
Jin Hong, Christine Lemieux, Scott D. Seiwert, Shawn Misialek, Robert Rieger, Dylan P. Hartley, Lawrence M. Blatt, Sharlene R. Lim, Kevin Ronald Condroski, Antitsa Dimitrova Stoycheva, Lin Pan, Hua Tan, Gary P. Hingorani, Leonid Beigelman, Hailong Zhang, John A. Josey, Xiaoli Qin, Karl Kossen, P. T. Ravi Rajagopalan, Mary Geck Do, Vladimir Serebryany, Sarah K. Stevens, Andrews Steven W, Jiang Yutong
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4432-4441
Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor of the NS3/4A protease of HCV, are descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9981ec4b6c65bf78b0076564bdd6d18a
https://doi.org/10.1128/aac.00699-08
https://doi.org/10.1128/aac.00699-08
Autor:
Peter R. Young, Jack R. Davis, Sriram Balasubramanian, Rafael A. Molina, Joseph J. Buggy, Stacie A. Dalrymple, Erik Verner, Ondine Callan, Liang Liu, Z. Alexander Cao, Christine Orr, Ling Leung, Brian E. Schultz, Kathryn E. Bass, YuQin Dai, Shawn Misialek, Martin Sendzik
Publikováno v:
Molecular Cancer Therapeutics. 5:1693-1701
CRA-026440 is a novel, broad-spectrum, hydroxamic acid–based inhibitor of histone deacetylase (HDAC) that shows antitumor and antiangiogenic activities in vitro and in vivo preclinically. CRA-026440 inhibited pure recombinant isozymes HDAC1, HDAC2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dfc96277b462e304646904a61ee240
https://doi.org/10.1158/1535-7163.mct-06-0042
https://doi.org/10.1158/1535-7163.mct-06-0042
Autor:
Sarah K. Stevens, Shawn Misialek, Karl Kossen, Scott D. Seiwert, Ravi Rajagopalan, Leonid Beigelman
Publikováno v:
Analytical biochemistry. 394(1)
The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is known to possess multiple enzymatic activities. In addition to its well-characterized protease activity, HCV NS3 also has ATP hydrolase (ATPase) and nucleic acid unwinding (helicase) activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461da619bcdaae65ad8b8d796e20aee2
https://pubmed.ncbi.nlm.nih.gov/19591800
https://pubmed.ncbi.nlm.nih.gov/19591800
Autor:
Shawn Misialek, Lisa Hooi, Guangyi Wang, Yanzhen He, Antitsa Dimitrova Stoycheva, Debasis Das, Mougang Hu, Jun Sun, Donald Ruhrmund, Leonid Beigelman, Scott D. Seiwert, Karl Kossen, Brad O. Buckman, Jianhua Huang, P. T. Ravi Rajagopalan
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
2-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d69fbe4c653de9ca4152f58421e72cc
https://pubmed.ncbi.nlm.nih.gov/19502055
https://pubmed.ncbi.nlm.nih.gov/19502055
Autor:
Shawn Misialek, P. T. Ravi Rajagopalan, Karl Kossen, Guangyi Wang, Xiaomin Wu, Laiguo Zhang, Debasis Das, Lisa Hooi, Donald Ruhrmund, Scott D. Seiwert, Brad O. Buckman, Leonid Beigelman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
3-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0839e538c66f81e14d0adfb051849f1
https://pubmed.ncbi.nlm.nih.gov/19497737
https://pubmed.ncbi.nlm.nih.gov/19497737
Autor:
Marion T. Conn, Brian E. Schultz, Jie Tang, Shawn Misialek, Ram Tahilramani, Lance Wong, Jiansheng Wu
Publikováno v:
Biochemistry. 43(34)
Histone deacetylase (HDAC) enzymes modulate gene expression through the deacetylation of acetylated lysine residues on histone proteins. They operate in biological systems as part of multiprotein corepressor complexes. To understand the reactivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba37c002b36bc64a7f88969909e1839
https://pubmed.ncbi.nlm.nih.gov/15323567
https://pubmed.ncbi.nlm.nih.gov/15323567
Autor:
Godrej Khambatta, Krzysztof Appelt, Shawn Misialek, Chris Pinko, Barbara Mroczkowski, Camran V. Parast
Publikováno v:
Biochemistry. 37(47)
Vascular endothelial growth factor (VEGF) is a dimeric protein which induces formation of new blood vessels (angiogenesis) through binding to VEGF-receptor-2 tyrosine kinase (VEGFR2 TK) or KDR (kinase insert domain-containing receptor) on the surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b4a2c6c31fc2fa2a53025a1c885e8
https://pubmed.ncbi.nlm.nih.gov/9843450
https://pubmed.ncbi.nlm.nih.gov/9843450
Autor:
Steven M. Firestine, Shawn Misialek, John R. Perfect, Dena L. Toffaletti, Thomas J. Klem, V. Jo Davisson
Publikováno v:
Archives of biochemistry and biophysics. 351(1)
Comparative studies of 5-aminoimidazole ribonucleotide (AIR) carboxylases from Escherichia coli and Gallus gallus have identified this central step in de novo purine biosynthesis as a case for unusual divergence in primary metabolism. Recent discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b412aaf4a2b34b9952e5d1362a4e82b
https://pubmed.ncbi.nlm.nih.gov/9500840
https://pubmed.ncbi.nlm.nih.gov/9500840