Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Shawn M. Gomez"'
Autor:
Matthew E. Berginski, Madison R. Jenner, Chinmaya U. Joisa, Gabriela Herrera Loeza, Brian T. Golitz, Matthew B. Lipner, Jack R. Leary, Naim Rashid, Gary L. Johnson, Jen Jen Yeh, Shawn M. Gomez
Publikováno v:
PeerJ, Vol 12, p e17797 (2024)
Numerous aspects of cellular signaling are regulated by the kinome—the network of over 500 protein kinases that guides and modulates information transfer throughout the cell. The key role played by both individual kinases and assemblies of kinases
Externí odkaz:
https://doaj.org/article/16b9aed8382349fc9144d2ba44859ea3
Autor:
Kevin A. Chen, Nina C. Nishiyama, Meaghan M. Kennedy Ng, Alexandria Shumway, Chinmaya U. Joisa, Matthew R. Schaner, Grace Lian, Caroline Beasley, Lee-Ching Zhu, Surekha Bantumilli, Muneera R. Kapadia, Shawn M. Gomez, Terrence S. Furey, Shehzad Z. Sheikh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Pediatric Crohn’s disease (CD) is characterized by a severe disease course with frequent complications. We sought to apply machine learning-based models to predict risk of developing future complications in pediatric CD using ileal and col
Externí odkaz:
https://doaj.org/article/979e1b72de6f43b790ae2ed45066b834
Autor:
Chinmaya U. Joisa, Kevin A. Chen, Matthew E. Berginski, Brian T. Golitz, Madison R. Jenner, Gabriela Herrera Loeza, Jen Jen Yeh, Shawn M. Gomez
Publikováno v:
PeerJ, Vol 11, p e16342 (2023)
Protein kinase activity forms the backbone of cellular information transfer, acting both individually and as part of a broader network, the kinome. Their central role in signaling leads to kinome dysfunction being a common driver of disease, and in p
Externí odkaz:
https://doaj.org/article/8bc2b6d4dbfe4288a0ab2733a2068d82
Autor:
Robert J. Mobley, Deepthi Raghu, Lauren D. Duke, Kayley Abell-Hart, Jon S. Zawistowski, Kyla Lutz, Shawn M. Gomez, Sujoy Roy, Ramin Homayouni, Gary L. Johnson, Amy N. Abell
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2387-2400 (2017)
The first epithelial-to-mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TSKI4 cells) induces an intermediate state of EMT, where cells retain stem
Externí odkaz:
https://doaj.org/article/c291185a476a427d8daabaff777c0e5d
Autor:
Eric A. Vitriol, Laura M. McMillen, Maryna Kapustina, Shawn M. Gomez, Dimitrios Vavylonis, James Q. Zheng
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 433-445 (2015)
Lamellipodia, the sheet-like protrusions of motile cells, consist of networks of actin filaments (F-actin) regulated by the ordered assembly from and disassembly into actin monomers (G-actin). Traditionally, G-actin is thought to exist as a homogeneo
Externí odkaz:
https://doaj.org/article/e47f3d4e156d40a9a32b645131c3248d
Autor:
Timothy J. Stuhlmiller, Samantha M. Miller, Jon S. Zawistowski, Kazuhiro Nakamura, Adriana S. Beltran, James S. Duncan, Steven P. Angus, Kyla A.L. Collins, Deborah A. Granger, Rachel A. Reuther, Lee M. Graves, Shawn M. Gomez, Pei-Fen Kuan, Joel S. Parker, Xin Chen, Noah Sciaky, Lisa A. Carey, H. Shelton Earp, Jian Jin, Gary L. Johnson
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 390-404 (2015)
Therapeutics that target ERBB2, such as lapatinib, often provide initial clinical benefit, but resistance frequently develops. Adaptive responses leading to lapatinib resistance involve reprogramming of the kinome through reactivation of ERBB2/ERBB3
Externí odkaz:
https://doaj.org/article/ed7a28c1915c491791b6cd80ddc9e842
Autor:
Matthew E. Berginski, Sarah J. Creed, Shelly Cochran, David W. Roadcap, James E. Bear, Shawn M. Gomez
Publikováno v:
PeerJ, Vol 2, p e462 (2014)
Multiple cell types form specialized protein complexes that are used by the cell to actively degrade the surrounding extracellular matrix. These structures are called podosomes or invadopodia and collectively referred to as invadosomes. Due to their
Externí odkaz:
https://doaj.org/article/296d060fe3ae4ba8800cbc41fefc79c9
Autor:
Kevin A, Chen, Chinmaya U, Joisa, Jonathan, Stem, Jose G, Guillem, Shawn M, Gomez, Muneera R, Kapadia
Publikováno v:
Dis Colon Rectum
Surgical site infection is a source of significant morbidity after colorectal surgery. Previous efforts to develop models that predict surgical site infection have had limited accuracy. Machine learning has shown promise in predicting post-operative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed80bac75fc39a51438442d9fae9640
https://doi.org/10.1097/dcr.0000000000002559
https://doi.org/10.1097/dcr.0000000000002559
Autor:
Kevin A. Chen, Chinmaya U. Joisa, Karyn B. Stitzenberg, Jonathan Stem, Jose G. Guillem, Shawn M. Gomez, Muneera R. Kapadia
Publikováno v:
Journal of Gastrointestinal Surgery. 26:2342-2350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ae0105c2de6fe39ff22cd9cc524430
https://doi.org/10.1007/s11605-022-05443-5
https://doi.org/10.1007/s11605-022-05443-5
Publikováno v:
Journal of the American College of Surgeons.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79a17e5fefe74de0399fa87c13e2a0eb
https://doi.org/10.1097/xcs.0000000000000676
https://doi.org/10.1097/xcs.0000000000000676