Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Shawn M. Gillespie"'
Autor:
Mihriban Karaayvaz, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor, Leif W. Ellisen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance si
Externí odkaz:
https://doaj.org/article/afc5c409cf52474faf19d8ea9034f824
Autor:
Russell J.H. Ryan, Jelena Petrovic, Dylan M. Rausch, Yeqiao Zhou, Caleb A. Lareau, Michael J. Kluk, Amanda L. Christie, Winston Y. Lee, Daniel R. Tarjan, Bingqian Guo, Laura K.H. Donohue, Shawn M. Gillespie, Valentina Nardi, Ephraim P. Hochberg, Stephen C. Blacklow, David M. Weinstock, Robert B. Faryabi, Bradley E. Bernstein, Jon C. Aster, Warren S. Pear
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 784-797 (2017)
Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely unknown. We perfor
Externí odkaz:
https://doaj.org/article/38f5e0dad5ea46838f521f8dde4cb919
Autor:
Esther Rheinbay, Mario L. Suvà, Shawn M. Gillespie, Hiroaki Wakimoto, Anoop P. Patel, Mohammad Shahid, Ozgur Oksuz, Samuel D. Rabkin, Robert L. Martuza, Miguel N. Rivera, David N. Louis, Simon Kasif, Andrew S. Chi, Bradley E. Bernstein
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1567-1579 (2013)
Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we present a comparative analysis of chromatin state in GBM CSCs that r
Externí odkaz:
https://doaj.org/article/61ad20f8b8db4ae4a36b359023e2d865
Autor:
Shawn M. Gillespie, Michelle Monje
Publikováno v:
Annual Review of Cancer Biology. 4:371-390
The nervous system is intimately involved in physiological processes from development and growth to tissue homeostasis and repair throughout the body. It logically follows that the nervous system has the potential to play analogous roles in the conte
Autor:
Pamelyn Woo, Michael Quezada, Yoon Seok Kim, Michelle Monje, Anna Geraghty, James Reed, Shawn M. Gillespie
Publikováno v:
Neuro Oncol
High-grade gliomas, including diffuse intrinsic pontine glioma, are lethal cancers whose progression is strongly regulated by neuronal activity. One way in which gliomas detect neuronal activity is via interaction with the ectodomain of post-synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c898dd1e3eeafda6c8f5f250b4acc57d
https://europepmc.org/articles/PMC8598778/
https://europepmc.org/articles/PMC8598778/
Autor:
Kelvin F Cho, Shawn M Gillespie, Nicholas A Kalogriopoulos, Michael A Quezada, Martin Jacko, Michelle Monje, Alice Y Ting
Publikováno v:
eLife. 11
Technologies for detecting cell-cell contacts are powerful tools for studying a wide range of biological processes, from neuronal signaling to cancer-immune interactions within the tumor microenvironment. Here, we report TRACC (Transcriptional Readou
Autor:
Hannes Vogel, Shawn M. Gillespie, Anna Geraghty, Dana Silverbush, Dwight E. Bergles, Lydia T. Tam, David Brang, Pamelyn Woo, Anitha Ponnuswami, Cedric Espenel, Kathryn R. Taylor, Lijun Ni, Mario L. Suvà, Marlene Arzt, Amit Agarwal, Shawn L. Hervey-Jumper, Robert C. Malenka, Aviv Regev, Humsa S. Venkatesh, Wade Morishita, Michelle Monje
Publikováno v:
Nature. 573:539-545
High-grade gliomas are lethal brain cancers whose progression is robustly regulated by neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but this alone is insufficient to explain the effect that neuronal activity
Autor:
Shawn M. Gillespie, Mariella G. Filbin, Mirhee Kim, Sanda Alexandrescu, Rhoda M. Alani, Muzhou Wu, Barry M. Zee, Bradley E. Bernstein, Jayanta Das, Jay H. Kalin, Dennis M. Bonal, Mario Andres Blanco, Yang Shi, Jamie N. Anastas, Mario L. Suvà, Philip A. Cole, Sarah E. Nocco, Stefanie Giera, Quang-Dé Nguyen, Todd R. Golub, Robyn Guo
Summary H3K27M mutations resulting in epigenetic dysfunction are frequently observed in diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer. We conduct a CRISPR screen revealing that knockout of KDM1A encoding lysine-specific deme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7985b7367f1f2b0f6ca319c3842d545
https://ora.ox.ac.uk/objects/uuid:3fae49db-2d10-4a57-bbd4-c0e4e76733e7
https://ora.ox.ac.uk/objects/uuid:3fae49db-2d10-4a57-bbd4-c0e4e76733e7
Autor:
J. Bradley Zuchero, David H. Gutmann, Kathryn R. Taylor, Shannon L. Macauley, Qingyun Li, Erin M. Gibson, Casey H. Halpern, Naresha Saligrama, F. Chris Bennett, Shawn M. Gillespie, Humsa S. Venkatesh, Laura Weiss Roberts, Sarah Kucenas, Belgin Yalçın, Ali D. Güler, Clete A. Kushida, Matthew A. Quinn, Shane A. Liddelow, Mackenzie Lemieux
Publikováno v:
Cell
The COVID19 crisis has magnified the issues plaguing academic science, but it has also provided the scientific establishment with an unprecedented opportunity to reset. Shoring up the foundation of academic science will require a concerted effort bet
Autor:
Christina C. Luo, Mihriban Karaayvaz, Anoop P. Patel, Franziska Michor, Shawn M. Gillespie, Leif W. Ellisen, Ravindra Mylvaganam, Simona Cristea, Bradley E. Bernstein, Michelle C. Specht
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell RNA-sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Here