Výsledky vyhledávání - "Shawn Kalloway"

Akademický článek

Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation

Autor: Thijs E. van Mens, Hai-Po H. Liang, Sreemanti Basu, Irene Hernandez, Mark Zogg, Jennifer May, Min Zhan, Qiuhui Yang, Jamie Foeckler, Shawn Kalloway, Rashmi Sood, Caren Sue Karlson, Hartmut Weiler

Publikováno v: Blood Advances, Vol 1, Iss 15, Pp 1148-1158 (2017)

Abstract: Thrombomodulin (Thbd) exerts pleiotropic effects on blood coagulation, fibrinolysis, and complement system activity by facilitating the thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor and may have a

Externí odkaz: https://doaj.org/article/8dc20687e39c4725a7cbdda6d7bf23da

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Abstract P292: Gene Editing Rat Resource Center: Rat Models for Heart, Lung, Blood, and Sleep Disorder Studies

Autor: Melinda R. Dwinell, Aron M. Geurts, Lynn Lazcares, Michael Grzybowski, Rebecca Schilling, Jamie Foeckler, Allison Zappa, Akiko Takizawa, Anne Temple, Jessica Niebuhr, Shawn Kalloway

Publikováno v: Hypertension. 72

Transgenesis and gene editing in the rat has produced gene-modified strains which can be used to validate a gene underlying a quantitative trait locus or human association, or to design follow up studies to define function and physiological roles of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a64f59fc4390d651fec4ff4474d0a074
https://doi.org/10.1161/hyp.72.suppl_1.p292

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Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding

Autor: Shawn Kalloway, Caroline E Kochelek, Veronica H. Flood, Jamie Foeckler, Tricia L Slobodianuk, Hartmut Weiler

Publikováno v: Journal of thrombosis and haemostasis : JTH. 17(1)

Essentials Defective binding to collagen IV has been seen in von Willebrand factor (VWF) A1 domain variants. We developed a murine model of defective VWF-collagen IV interactions with VWF variant p.R1399H. p.1399HH homozygous mice had decreased bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb1ad36e6219c989afbff4c2cbb5325
https://pubmed.ncbi.nlm.nih.gov/30565388

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Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation

Autor: Rashmi Sood, Jennifer May, Qiuhui Yang, Hai-Po H. Liang, Shawn Kalloway, Thijs E. van Mens, Jamie Foeckler, Hartmut Weiler, Mark Zogg, Min Zhan, Irene Hernandez, Caren Sue Karlson, Sreemanti Basu

Publikováno v: Blood advances, 1(15), 1148-1158. American Society of Hematology

Thrombomodulin (Thbd) exerts pleiotropic effects on blood coagulation, fibrinolysis, and complement system activity by facilitating the thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor and may have additional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cfd9540ac1538026160c2baac1055c
https://pubmed.ncbi.nlm.nih.gov/28920104

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Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains

Autor: Gregory D. Davis, Michael Grzybowski, Rebecca Schilling, Akiko Takizawa, Haiyan Xu, Aron M. Geurts, Shawn Kalloway, Howard J. Jacob, Jamie Foeckler, Monika Gjoka, Allison Zappa, Colin Hansen, Sheng Yang

Publikováno v: Stem cells and development.

The lack of rat embryonic stem cells (ESCs) and approaches for manipulation of their genomes have restricted the ability to create new genetic models and to explore the function of a single gene in complex diseases in the laboratory rat. The recent b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ea36db297b1926dfb108c5ad6fd18e
https://pubmed.ncbi.nlm.nih.gov/24083560

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Knockout rats via embryo microinjection of zinc-finger nucleases

Publikováno v: Science (New York, N.Y.). 325(5939)

The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. By using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dfde293036e526492b11e92ebd5362
https://pubmed.ncbi.nlm.nih.gov/19628861

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Bleeding Phenotype Observed in Murine Defect of VWF-Collagen 4 Interactions

Autor: Tricia L Slobodianuk, Derek Adams, Veronica H. Flood, Hartmut Weiler, Shawn Kalloway, Jamie Foeckler, Ashley L. Doruelo, Robert R. Montgomery

Publikováno v: Blood. 126:211-211

VWF binding to type 4 collagen has recently been shown to occur via the VWF A1 domain, but the clinical implications of this interaction remain to be elucidated. In humans, the R1399H sequence variant (2% of the Caucasian population is heterozygous f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23c945759ae6753709dde0948ffaa0cd
https://doi.org/10.1182/blood.v126.23.211.211

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Crispr/Cas9-Mediated Generation of Mouse Platelets Expressing the Human Platelet Alloantigen, HPA-1a

Autor: Shawn Kalloway, Huiying Zhi, Nanyan Zhang, Jamie Foeckler, Hartmut Weiler, Peter J. Newman, Brian R. Curtis, Sridhar Rao

Publikováno v: Blood. 126:2341-2341

Human platelet alloantigens (HPAs) are caused by single nucleotide polymorphisms within functionally important platelet membrane glycoproteins. Antibodies against HPAs have been implicated in several clinically important alloimmune platelet disorders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ea699567c99d47187d35232e1b2830c
https://doi.org/10.1182/blood.v126.23.2341.2341

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