Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shawn K. Milano"'
Autor:
Cody Aplin, Kara A. Zielinski, Suzette Pabit, Deborah Ogunribido, William P. Katt, Lois Pollack, Richard A. Cerione, Shawn K. Milano
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Transglutaminase 2 (TG2) is a GTP-binding, protein-crosslinking enzyme that has been investigated as a therapeutic target for Celiac disease, neurological disorders, and aggressive cancers. TG2 has been suggested to adopt two conformational
Externí odkaz:
https://doaj.org/article/c30285b37bdd4cb1aa637ea1b450312e
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate, satisfying the ‘glutamine addiction’ of cancer cells. They are the targets of anti-cancer drugs; however, their mechanisms of activation and catalyti
Externí odkaz:
https://doaj.org/article/0e74d97efe8c4ed9bbc126d24beb796e
Autor:
Kara A. Zielinski, Andrea M. Katz, George D. Calvey, Suzette A. Pabit, Shawn K. Milano, Cody Aplin, Josue San Emeterio, Richard A. Cerione, Lois Pollack
Publikováno v:
IUCrJ, Vol 10, Iss 3, Pp 363-375 (2023)
Advances in time-resolved structural techniques, mainly in macromolecular crystallography and small-angle X-ray scattering (SAXS), allow for a detailed view of the dynamics of biological macromolecules and reactions between binding partners. Of parti
Externí odkaz:
https://doaj.org/article/845924a548ac481394f8df26f15ff8be
Publikováno v:
J Phys Chem B
Structure-based drug design (SBDD) is a prominent method in rational drug development and has traditionally benefitted from the atomic models of protein targets obtained using X-ray crystallography at cryogenic temperatures. In this perspective, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acbcac93ef619ffbf4cc6eda8a0534e
https://doi.org/10.1021/acs.jpcb.2c04344
https://doi.org/10.1021/acs.jpcb.2c04344
Autor:
Pavel Sidorenko, Qingqiu Huang, David Closs, Gabrielle Illava, Wenjie Zeng, Frank W. Wise, Robert E. Thorne, Benjamin Apker, A.D. Finke, Richard Jayne, Warren R. Zipfel, Irina A. Kriksunov, Shawn K. Milano
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
A highly flexible, integrated system for preparing samples for serial synchrotron crystallography at room and cryogenic temperatures is described and evaluated. The system is compatible with the existing infrastructure for high-throughput crystallogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bb2dad5d4e35b133d7512c5212e72c
https://doi.org/10.1107/s2059798321001868
https://doi.org/10.1107/s2059798321001868
Autor:
Shawn K. Milano, Qingqiu Huang, Thuy-Tien T. Nguyen, Sekar Ramachandran, Aaron Finke, Irina Kriksunov, David J. Schuller, D. Marian Szebenyi, Elke Arenholz, Lee A. McDermott, N. Sukumar, Richard A. Cerione, William P. Katt
Publikováno v:
The Journal of Biological Chemistry
Cancer cells frequently exhibit uncoupling of the glycolytic pathway from the TCA cycle (i.e., the “Warburg effect”) and as a result, often become dependent on their ability to increase glutamine catabolism. The mitochondrial enzyme Glutaminase C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa822c06b16d7fdb357d1867222ee3bf
https://pubmed.ncbi.nlm.nih.gov/34954143
https://pubmed.ncbi.nlm.nih.gov/34954143
Autor:
Thuy-Tien T. Nguyen, Sekar Ramachandran, Lee Apostle Mcdermott, Elke Arenholz, Marian Szebenyi, David J. Schuller, A.D. Finke, Irina A. Kriksunov, Qingqiu Huang, Shawn K. Milano, Nagamani Sukumar, Richard A. Cerione, William P. Katt
Many cancer cells become dependent on glutamine metabolism to compensate for glycolysis being uncoupled from the TCA cycle. The mitochondrial enzyme Glutaminase C (GAC) satisfies this ‘glutamine addiction’ by catalyzing the first step in glutamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b821c9abcce32642fbf473fe94ee913a
https://doi.org/10.1101/2021.09.20.461106
https://doi.org/10.1101/2021.09.20.461106
Publikováno v:
Journal of Biological Chemistry. 293:17941-17952
Two regions on the α subunits of heterotrimeric GTP-binding proteins (G-proteins), the Switch II/α2 helix (which changes conformation upon GDP–GTP exchange) and the α3 helix, have been shown to contain the binding sites for their effector protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648be5f704a5479d9f934a83eae94744
https://doi.org/10.1074/jbc.ra118.003746
https://doi.org/10.1074/jbc.ra118.003746
Autor:
Shawn K. Milano, Tri Nguyen, Changhwan Ahn, Jeongmin Song, Gyeongshik Yoo, Yi-An Yang, James C. Paulson, Andrew J. Thompson, Sohyoung Lee, Eric C. Hillpot, Ji Hyun Sim
Publikováno v:
Cell hostmicrobe. 27(6)
Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b2eed8664f70f29a046481a0c4298f
https://pubmed.ncbi.nlm.nih.gov/32526179
https://pubmed.ncbi.nlm.nih.gov/32526179
Autor:
Andrew J. Thompson, Ji Hyun Sim, Sohyoung Lee, Gyeongshik Yoo, James C. Paulson, Tri Nguyen, Eric C. Hillpot, Shawn K. Milano, Jeongmin Song, Yi-An Yang
Publikováno v:
SSRN Electronic Journal.
Typhoidal and nontyphoidal Salmonellae (NTS) cause typhoid fever and gastroenteritis respectively in humans. Typhoid toxin from typhoidal Salmonella contributes to typhoid disease progression and chronic infection, but little is known about its ortho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfb860ecdeb3404d15e523298bef3c9e
https://doi.org/10.2139/ssrn.3413892
https://doi.org/10.2139/ssrn.3413892