Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Shawn J Skerrett"'
Autor:
Kathryn M Ramsey, Hannah E Ledvina, Tenayaann M Tresko, Jamie M Wandzilak, Catherine A Tower, Thomas Tallo, Caroline E Schramm, S Brook Peterson, Shawn J Skerrett, Joseph D Mougous, Simon L Dove
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008566 (2020)
Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing screen, we identified several F. tularensis genes that play central and previo
Externí odkaz:
https://doaj.org/article/4fb8a5aa854c48928b939a0b7ad93584
Autor:
T Eoin West, Nicolle D Myers, Narisara Chantratita, Wirongrong Chierakul, Direk Limmathurotsakul, Vanaporn Wuthiekanun, Edward A Miao, Adeline M Hajjar, Sharon J Peacock, H Denny Liggitt, Shawn J Skerrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3178 (2014)
Burkholderia pseudomallei causes the tropical infection melioidosis. Pneumonia is a common manifestation of melioidosis and is associated with high mortality. Understanding the key elements of host defense is essential to developing new therapeutics
Externí odkaz:
https://doaj.org/article/20fed37201ba44828db72d9b63bc1dfa
Autor:
Kathie-Anne Walters, Rachael Olsufka, Rolf E Kuestner, Ji Hoon Cho, Hong Li, Gregory A Zornetzer, Kai Wang, Shawn J Skerrett, Adrian Ozinsky
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62412 (2013)
Pulmonary exposure to Francisella tularensis is associated with severe lung pathology and a high mortality rate. The lack of induction of classical inflammatory mediators, including IL1-β and TNF-α, during early infection has led to the suggestion
Externí odkaz:
https://doaj.org/article/10a7b448b18645ae8933f90e24e957df
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41329 (2012)
Staphylococcus aureus is a common inhabitant of the human nasopharynx. It is also a cause of life-threatening illness, producing a potent array of virulence factors that enable survival in normally sterile sites. The transformation of S. aureus from
Externí odkaz:
https://doaj.org/article/5194f452a81d4e98a3f9653eb46cde28
Autor:
Sandra Schwarz, T Eoin West, Frédéric Boyer, Wen-Chi Chiang, Mike A Carl, Rachel D Hood, Laurence Rohmer, Tim Tolker-Nielsen, Shawn J Skerrett, Joseph D Mougous
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001068 (2010)
Bacteria that live in the environment have evolved pathways specialized to defend against eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the role of the five type VI secretion systems (T6SSs) of Burkholderia th
Externí odkaz:
https://doaj.org/article/6b331782aa9c40a58562c3996ab1a559
Autor:
Duangjit Kanistanon, Adeline M Hajjar, Mark R Pelletier, Larry A Gallagher, Thomas Kalhorn, Scott A Shaffer, David R Goodlett, Laurence Rohmer, Mitchell J Brittnacher, Shawn J Skerrett, Robert K Ernst
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e24 (2008)
Francisella tularensis (Ft) is a highly infectious gram-negative bacterium and the causative agent of the human disease tularemia. Ft is designated a class A select agent by the Centers for Disease Control and Prevention. Human clinical isolates of F
Externí odkaz:
https://doaj.org/article/d2bb1198864c4636913be5652c044e88
Autor:
Hrishikesh S. Kulkarni, Janet S. Lee, Julie A. Bastarache, Wolfgang M. Kuebler, Gregory P. Downey, Guillermo M. Albaiceta, William A. Altemeier, Antonio Artigas, Jason H. T. Bates, Carolyn S. Calfee, Charles S. Dela Cruz, Robert P. Dickson, Joshua A. Englert, Jeffrey I. Everitt, Michael B. Fessler, Andrew E. Gelman, Kymberly M. Gowdy, Steve D. Groshong, Susanne Herold, Robert J. Homer, Jeffrey C. Horowitz, Connie C. W. Hsia, Kiyoyasu Kurahashi, Victor E. Laubach, Mark R. Looney, Rudolf Lucas, Nilam S. Mangalmurti, Anne M. Manicone, Thomas R. Martin, Sadis Matalon, Michael A. Matthay, Daniel F. McAuley, Sharon A. McGrath-Morrow, Joseph P. Mizgerd, Stephanie A. Montgomery, Bethany B. Moore, Alexandra Noël, Carrie E. Perlman, John P. Reilly, Eric P. Schmidt, Shawn J. Skerrett, Tomeka L. Suber, Charlotte Summers, Benjamin T. Suratt, Masao Takata, Rubin Tuder, Stefan Uhlig, Martin Witzenrath, Rachel L. Zemans, Gutavo Matute-Bello
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:e1-e14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74839f7126fbd7a58c1527ef783f44f4
https://doi.org/10.1165/rcmb.2021-0531st
https://doi.org/10.1165/rcmb.2021-0531st
Autor:
Yaxi Wang, Hannah E. Ledvina, Catherine A. Tower, Stanimir Kambarev, Elizabeth Liu, James C. Charity, Lieselotte S.M. Kreuk, Qiwen Chen, Larry A. Gallagher, Matthew C. Radey, Guilhem F. Rerolle, Yaqiao Li, Kelsi M. Penewit, Serdar Turkarslan, Shawn J. Skerrett, Stephen J. Salipante, Nitin S. Baliga, Joshua J. Woodward, Simon L. Dove, S. Brook Peterson, Jean Celli, Joseph D. Mougous
Glutathione (GSH) is an abundant metabolite that can act as a signal, a nutrient source, or serve in a redox capacity for intracellular pathogens. For Francisella, GSH is thought to be a critical in vivo source of cysteine; however, the cellular path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::122a832db15a611c18edbe66c6192ce2
https://doi.org/10.1101/2023.02.02.526638
https://doi.org/10.1101/2023.02.02.526638
Autor:
Sorin Tunaru, Monica Campo, Glenna J. Peterson, Jenny Lohmiller, Shawn J. Skerrett, Jason D. Simmons, Stefan Offermanns, Thomas R. Hawn, David R. Sherman
Publikováno v:
The Journal of Infectious Diseases
Novel antimicrobials for treatment of Mycobacterium tuberculosis are needed. We hypothesized that nicotinamide (NAM) and nicotinic acid (NA) modulate macrophage function to restrict M. tuberculosis replication in addition to their direct antimicrobia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9c9f47203509159002666567ca5699
http://europepmc.org/articles/PMC7050990
http://europepmc.org/articles/PMC7050990
Autor:
Anthony J. Convertine, T. Eoin West, Debobrato Das, Patrick S. Stayton, Taylor Monroe-Jones, Jasmin Chen, Brian Lee, Daniel M. Ratner, Hye Nam Son, Frank Radella, Shawn J. Skerrett, Dale Whittington, Fang-Yi Su, Selvi Srinivasan
Publikováno v:
Biomaterials. 195:38-50
Alveolar macrophages resident in the lung are prominent phagocytic effector cells of the pulmonary innate immune response, and paradoxically, are attractive harbors for pathogens. Consequently, facultative intracellular bacteria, such as Francisella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0cc1f9e718233989a44d3eb068bb0f
https://doi.org/10.1016/j.biomaterials.2018.10.017
https://doi.org/10.1016/j.biomaterials.2018.10.017