Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Shawn Hingtgen"'
Autor:
Xing Cheng, Jing An, Jitong Lou, Qisheng Gu, Weimin Ding, Gaith Nabil Droby, Yilin Wang, Chenghao Wang, Yanzhe Gao, Jay Ramanlal Anand, Abigail Shelton, Andrew Benson Satterlee, Breanna Mann, Yun-Chung Hsiao, Chih-Wei Liu, Kun Lu, Shawn Hingtgen, Jiguang Wang, Zhaoliang Liu, C. Ryan Miller, Di Wu, Cyrus Vaziri, Yang Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible
Externí odkaz:
https://doaj.org/article/30b03460503c40948e61ba53f8ff91ba
Autor:
Andrew B. Satterlee, Denise E. Dunn, Alain Valdivia, Daniel Malawsky, Andrew Buckley, Timothy Gershon, Scott Floyd, Shawn Hingtgen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 49-62 (2022)
Genetically engineered neural stem cells (NSCs) are a promising therapy for the highly aggressive brain cancer glioblastoma (GBM); however, treatment durability remains a major challenge. We sought to define the events that contribute to dynamic adap
Externí odkaz:
https://doaj.org/article/8ffa4d8cfc434782b7cecb4a73bb16bd
Autor:
Shawn Hingtgen, Randa Kasmieh, Elizabeth Elbayly, Irina Nesterenko, Jose-Luiz Figueiredo, Rupesh Dash, Devanand Sarkar, David Hall, Dima Kozakov, Sandor Vajda, Paul B Fisher, Khalid Shah
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40234 (2012)
Creating new molecules that simultaneously enhance tumor cell killing and permit diagnostic tracking is vital to overcoming the limitations rendering current therapeutic regimens for terminal cancers ineffective. Accordingly, we investigated the effi
Externí odkaz:
https://doaj.org/article/b13b7d1b8f9b4a4cbabf6827fe023fc2
Autor:
Juan Beltran-Huarac, Dina N. Yamaleyeva, Gianpietro Dotti, Shawn Hingtgen, Marina Sokolsky-Papkov, Alexander V. Kabanov
Publikováno v:
ACS Applied Materials & Interfaces. 15:19877-19891
Autor:
Khalid Shah, Ralph Weissleder, Umar Mahmood, Henry Bergquist, Jose-Luiz Figueiredo, Shawn Hingtgen, Esther Arwert
Many altered pathways in cancer cells depend on growth factor receptors. In primary malignant gliomas, the amplification/alteration of the epidermal growth factor receptor (EGFR) has been shown to play a significant role in enhancing glioma burden. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53667de8fc7c1495a06d029195334c8f
https://doi.org/10.1158/0008-5472.c.6495884
https://doi.org/10.1158/0008-5472.c.6495884
Autor:
Khalid Shah, Ralph Weissleder, Umar Mahmood, Henry Bergquist, Jose-Luiz Figueiredo, Shawn Hingtgen, Esther Arwert
Supplementary Figure 1 from Visualizing the Dynamics of EGFR Activity and Antiglioma Therapies In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78acbfa80f77739d0bb0bede6b4e1db7
https://doi.org/10.1158/0008-5472.22368269.v1
https://doi.org/10.1158/0008-5472.22368269.v1
Publikováno v:
Neuro-Oncology Advances. 5
Glioblastoma (GBM) is the most prevalent, aggressive, primary brain cancer in adults and continues to pose major medical challenges due in part to its high rate of recurrence. Extensive research is underway to discover new therapies that target GBM c
Autor:
Breanna Mann, Xiaopei Zhang, Noah Bell, Adebimpe Adefolaju, Morrent Thang, Rajaneekar Dasari, Krishna Kanchi, Alain Valdivia, Yang Yang, Andrew Buckley, Vivien Lettry, Carolyn Quinsey, Yasmeen Rauf, David Kram, Noah Cassidy, Cyrus Vaziri, David L. Corcoran, Stephen Rego, Yuchao Jiang, Lee M. Graves, Denise Dunn, Scott Floyd, Albert Baldwin, Shawn Hingtgen, Andrew B. Satterlee
Publikováno v:
Cell Reports Medicine. :101042
Autor:
Breanna Mann, Xiaopei Zhang, Noah Bell, Adebimpe Adefolaju, Rajaneekar Dasari, Shawn Hingtgen, Andrew Satterlee
Publikováno v:
Neuro-Oncology. 24:vii299-vii300
The lack of experimentally tractable models that recapitulate brain structure and function represents a major impediment in the development of novel treatment options for brain cancer. In vitro assays, though fast and high throughput, produce artific
Autor:
Hunter Bomba, Lauren Kass, Abigail Carey-Ewend, Kevin Sheets, Alain Valdivia, Morgan Goetz, Ingrid Findlay, Alison Mercer-Smith, Simon Khagi, Shawn Hingtgen
Publikováno v:
Neuro-Oncology. 24:vii94-vii95
Therapeutic neural stem cells (tNSCs) are a promising new platform for the treatment of glioblastoma (GBM). tNSCs exhibit a characteristic known as tumor tropism, in which they can migrate towards distant GBM foci via cytokine signaling. Complementar