Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shawn Eisenberg"'
Autor:
Dariusz Śmiłowicz, Shawn Eisenberg, Shin Hye Ahn, Angus J. Koller, Philip P. Lampkin, Eszter Boros
Publikováno v:
Chemical Science. 14:5038-5050
Chelator-mediated solid-phase capture, followed by photochemical cleavage provides radiopharmaceuticals in a ready-to-inject form for excellent in vivo performance in a preclinical mouse model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bff4feb538da9423c6e17065bc4fb94
https://doi.org/10.1039/d2sc06977f
https://doi.org/10.1039/d2sc06977f
Autor:
Yuelie Lu, Ling Wang, Michael Handley, Ning Xi, Stephen Arvedson, Andrew Tasker, Jiandong Zhang, Tingjian Xiang, Osslund Timothy D, Celia Dominguez, Qi Huang, Liang Huang, David Powers, Nianhe Han, Gladys Nunez, Qingyian Liu, Jiawang Zhu, Shawn Eisenberg, Shimin Xu, Alexander S. Kiselyov, Richard Kendall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2905-2909
Novel αvβ3 antagonists based on the N-aryl-γ-lactam scaffold were prepared. SAR studies led to the identification of potent antagonists for αvβ3 receptor with excellent selectivity against the structurally related αIIbβ3 receptor. Additional i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6327503f49e45e3cee545d9f88871868
https://doi.org/10.1016/j.bmcl.2004.03.033
https://doi.org/10.1016/j.bmcl.2004.03.033
Publikováno v:
Tetrahedron Letters. 43:3963-3966
A one-pot route to 3-benzo[b]thiophen-2-yl-acrylates ( 2 ) from the corresponding thiophenols ( 1 ) is reported. Ester reduction and subsequent hydroxyl esterification deliver psuedo trienoates ( II ) which undergo an intramolecular Diels–Alder (IM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::849832bda235d66025076b46d3fa563d
https://doi.org/10.1016/s0040-4039(02)00565-8
https://doi.org/10.1016/s0040-4039(02)00565-8
Publikováno v:
Tetrahedron Letters. 40:2465-2468
Efficient assembly of 14-membered macrocycles utilizing S N Ar of fluorine in 3-fluoro-4-nitrobenzoic acid with the OH of 3-hydroxytyrosine on the solid support is reported. The flexibility of this synthesis, as well as the excellent purity (>90%) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdaa11792d5fd89e0c3cbddaaf55b143
https://doi.org/10.1016/s0040-4039(99)00278-6
https://doi.org/10.1016/s0040-4039(99)00278-6
Autor:
Shawn Eisenberg, Xin Wang, Ben Zhi, Jean Baum, Liang Huang, Richard D. Crockett, Ying Chen, Robert D. Larsen, John Ng, Paul J. Reider, Mike Martinelli
Publikováno v:
The Journal of organic chemistry. 71(10)
A practical synthesis of a key pharmaceutical intermediate, 2-[(1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino]-5-fluoronicotinic acid (1), is described. To introduce the aminomethyl moiety of 2 via a palladium-catalyzed cyanation/reduction sequence, a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4390183a597c39ed738ec008c3551fca
https://pubmed.ncbi.nlm.nih.gov/16674090
https://pubmed.ncbi.nlm.nih.gov/16674090
Autor:
Ning, Xi, Stephen, Arvedson, Shawn, Eisenberg, Nianhe, Han, Michael, Handley, Liang, Huang, Qi, Huang, Alexander, Kiselyov, Qingyian, Liu, Yuelie, Lu, Gladys, Nunez, Timothy, Osslund, David, Powers, Andrew S, Tasker, Ling, Wang, Tingjian, Xiang, Shimin, Xu, Jiandong, Zhang, Jiawang, Zhu, Richard, Kendall, Celia, Dominguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(11)
Novel alphavbeta3 antagonists based on the N-aryl-gamma-lactam scaffold were prepared. SAR studies led to the identification of potent antagonists for alphavbeta3 receptor with excellent selectivity against the structurally related alpha(IIb)beta3 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a62399057fa2ca8aa951ae3c15a60f1
https://pubmed.ncbi.nlm.nih.gov/15125957
https://pubmed.ncbi.nlm.nih.gov/15125957
Publikováno v:
ChemInform. 33:117-117
A one-pot route to 3-benzo[b]thiophen-2-yl-acrylates ( 2 ) from the corresponding thiophenols ( 1 ) is reported. Ester reduction and subsequent hydroxyl esterification deliver psuedo trienoates ( II ) which undergo an intramolecular Diels–Alder (IM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c63102cf7e5edd0318bd46e013067d
https://doi.org/10.1002/chin.200235117
https://doi.org/10.1002/chin.200235117