Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shawn E Kuhmann"'
Autor:
Cleo G Anastassopoulou, Andre J Marozsan, Alexandre Matet, Amy D Snyder, Eric J Arts, Shawn E Kuhmann, John P Moore
Publikováno v:
PLoS Pathogens, Vol 3, Iss 6, p e79 (2007)
Fitness is a parameter used to quantify how well an organism adapts to its environment; in the present study, fitness is a measure of how well strains of human immunodeficiency virus type 1 (HIV-1) replicate in tissue culture. When HIV-1 develops res
Externí odkaz:
https://doaj.org/article/96c2514afa774e0aac42b2f29bf3eb83
Autor:
Thomas J. Ketas, Sunil K. Ahuja, Ashley M. Palmer, John P. Moore, Shawn E. Kuhmann, Weijing He, Juan Zurita, Per Johan Klasse
Publikováno v:
Virology. 364(2):281-290
Several CCR5 ligands, including small molecules and monoclonal antibodies (MAbs), are being developed as therapies for infection with strains of human immunodeficiency virus type 1 (HIV-1) that use CCR5 for entry (R5 viruses). The efficacy of such th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd767add393dce5c13af275252fadb7
Autor:
Stuart W. McCombie, Thomas P. Sakmar, Tatjana Dragic, Fotini Tsamis, Bahige M. Baroudy, Christoph Seibert, John W. Clader, John P. Moore, Anandan Palani, Svetlana Gavrilov, Shawn E. Kuhmann, Jayaram R. Tagat, Steven O. Smith, Weiwen Ying
Publikováno v:
Virology. 349(1):41-54
The CC-chemokine receptor 5 (CCR5) is the major coreceptor for macrophage-tropic (R5) HIV-1 strains. Several small molecule inhibitors of CCR5 that block chemokine binding and HIV-1 entry are being evaluated as drug candidates. Here we define how CCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bf7b55794ac5ea33b739e547cfe2a9
Autor:
Erika Billick, Michael J. Endres, Bahige M. Baroudy, Alexandra Trkola, Pavel Pugach, Shawn E. Kuhmann, Tom Ketas, Nicholas J. Murgolo, Thomas P. Sakmar, Christoph Seibert, John P. Moore, Gregory R. Reyes, Elizabeth Coates
Publikováno v:
Journal of Virology. 78:4134-4144
AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque CCR5, but SCH-C does not. Among the eight residues tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669f86d51f24b735bfccb3485e07762e
https://doi.org/10.1128/jvi.78.8.4134-4144.2004
https://doi.org/10.1128/jvi.78.8.4134-4144.2004
Autor:
Ian A. Wilson, Bette T. Korber, Janice Riley, Steven M. Wolinsky, Kevin J. Kunstman, Pavel Pugach, Julie M. Strizki, Shawn E. Kuhmann, John P. Moore, Bahige M. Baroudy, Amy Snyder, Joann M. Taylor, Robyn L. Stanfield
Publikováno v:
Journal of Virology. 78:2790-2807
We have described previously the generation of an escape variant of human immunodeficiency virus type 1 (HIV-1), under the selection pressure of AD101, a small molecule inhibitor that binds the CCR5 coreceptor (A. Trkola, S. E. Kuhmann, J. M. Strizki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93abb82f3b5a4e3d8c130c25d032af2b
https://doi.org/10.1128/jvi.78.6.2790-2807.2004
https://doi.org/10.1128/jvi.78.6.2790-2807.2004
Autor:
Andre J. Marozsan, Amy Snyder, Thomas J. Ketas, Steven M. Wolinsky, Shawn E. Kuhmann, Pavel Pugach, Joann M. Taylor, John P. Moore, Bette T. Korber
Publikováno v:
Virology. 321:8-22
Primary strains of human immunodeficiency virus type 1 (HIV-1) are known to adapt to replication in cell lines in vitro by becoming sensitive to soluble CD4 (sCD4) and neutralizing antibodies (NAb). T-cell lines favor isolation of variants that use C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ff5da21bd9ed6308161c29e593ae69
https://doi.org/10.1016/j.virol.2003.12.012
https://doi.org/10.1016/j.virol.2003.12.012
Autor:
Shawn E. Kuhmann, John P. Moore
Publikováno v:
Trends in Pharmacological Sciences. 25:117-120
BMS-378806 is a newly described small-molecule inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. It acts by binding to the gp120 surface glycoprotein of the virus within, or very close to, the pocket normally occupied by the CD4 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9f648f3512fe6753cc8f08955841e
https://doi.org/10.1016/j.tips.2004.01.005
https://doi.org/10.1016/j.tips.2004.01.005
Autor:
Tom Ketas, Jayaram R. Tagat, John W. Clader, Thomas P. Sakmar, Bahige M. Baroudy, Alexandra Trkola, Fotini Tsamis, Christoph Seibert, Svetlana Gavrilov, Francis Kajumo, Anadan Palani, John P. Moore, Shawn E. Kuhmann, Tatjana Dragic, Stuart W. McCombie
Publikováno v:
Journal of Virology. 77:5201-5208
Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the consecutive interaction of the envelope glycoprotein gp120 with CD4 and a coreceptor such as CCR5 or CXCR4. The CCR5 coreceptor is used by the most commonly transmitted HIV-1 strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f00b025062d7674338c9a7ff16a42b5
https://doi.org/10.1128/jvi.77.9.5201-5208.2003
https://doi.org/10.1128/jvi.77.9.5201-5208.2003
Autor:
Lisa Wojcik, Sherry Shapiro, Shawn E. Kuhmann, John W. Clader, Serena Xu, Stuart W. McCombie, Gregory R. Reyes, Julie M. Strizki, Jayaram R. Tagat, Tom Ketas, Elizabeth S. Maxwell, John P. Moore, Thomas Hunt Morgan, Bahige M. Baroudy, Alexandra Trkola, Pavel Pugach, Anandan Palani
Publikováno v:
Proceedings of the National Academy of Sciences. 99:395-400
To study HIV-1 escape from a coreceptor antagonist, the R5 primary isolate CC1/85 was passaged in peripheral blood mononuclear cells with increasing concentrations of the CCR5-specific small molecule inhibitor, AD101. By 19 passages, an escape mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::855b983b32ab7ba68835b7674012511a
https://doi.org/10.1073/pnas.012519099
https://doi.org/10.1073/pnas.012519099
Autor:
James M. Binley, Shawn E. Kuhmann, Charmagne Cayanan, Aditi Master, Rogier W. Sanders, Linnea Schiffner, John P. Moore, Shiu Lok Hu, Dennis R. Burton, Cheryl Wiley, William C. Olson, Bruce M. Travis
Publikováno v:
Journal of virology, 76(6), 2606-2616. American Society for Microbiology
In virus-infected cells, the envelope glycoprotein (Env) precursor, gp160, of human immunodeficiency virus type 1 is cleaved by cellular proteases into a fusion-competent gp120-gp41 heterodimer in which the two subunits are noncovalently associated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4caca93a28aeaa83f789a6cbcb698e9
https://doi.org/10.1128/jvi.76.6.2606-2616.2002
https://doi.org/10.1128/jvi.76.6.2606-2616.2002