Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shawn DeFrees"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 9, Pp 1651-1657 (2023)
This study attempts to answer the question of whether mice with biallelic and monoallelic disruption of the St3gal5 (GM3 synthase) gene might benefit from GM1 replacement therapy. The GM3 produced by this sialyltransferase gives rise to downstream GD
Externí odkaz:
https://doaj.org/article/01e38b64fcdb4d55a0368214a02f3bce
Publikováno v:
Journal of Molecular Neuroscience. 63:100-114
Juvenile Batten disease (JBD) is an inherited disorder that is characterized by the development of blindness, seizures, and progressive motor, psychiatric, and cognitive impairment. A model of JBD expressing the predominant human mutation (Cln3 ∆ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28cde9433522d2dd65a4fcad31f7671
https://doi.org/10.1007/s12031-017-0962-5
https://doi.org/10.1007/s12031-017-0962-5
Publikováno v:
Experimental neurology. 329
Parkinson's disease (PD) is a major neurodegenerative disorder characterized by a variety of non-motor symptoms in addition to the well-recognized motor dysfunctions that have commanded primary interest. We previously described a new PD mouse model b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5991f9afec5082e5e24e3bb65bb4cea8
https://pubmed.ncbi.nlm.nih.gov/32165255
https://pubmed.ncbi.nlm.nih.gov/32165255
Publikováno v:
Journal of molecular neuroscience : MN. 63(1)
Juvenile Batten disease (JBD) is an inherited disorder that is characterized by the development of blindness, seizures, and progressive motor, psychiatric, and cognitive impairment. A model of JBD expressing the predominant human mutation (Cln3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e5b74509ef5a7bfe055be01084f5678
https://pubmed.ncbi.nlm.nih.gov/28812237
https://pubmed.ncbi.nlm.nih.gov/28812237
Autor:
Sadia Rahmani, Stephen G. Withers, Laura Kell, Warren W. Wakarchuk, Nakita Buenbrazo, Lyann Sim, Shawn Defrees, Ting Du
Publikováno v:
Cell Chemical Biology. 26:203-212.e5
Summary We have developed an Escherichia coli strain for the in vivo production of O-glycosylated proteins. This was achieved using a dual plasmid approach: one encoding a therapeutic protein target, and a second encoding the enzymatic machinery requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612ed147647930b66cd2bb0f8685d4b9
https://doi.org/10.1016/j.chembiol.2018.10.017
https://doi.org/10.1016/j.chembiol.2018.10.017
Autor:
Warren W. Wakarchuk, Marie-France Karwaski, Stéphane Bernatchez, Jianjun Li, Shawn Defrees, Michel Gilbert, Marie-Claude Blanchard
Publikováno v:
Glycobiology. 17:1333-1343
The gene clusters encoding the lipooligosaccharide biosynthesis glycosyltransferases from Campylobacter jejuni have previously been divided in eight classes based on their genetic organization. Here, three variants of the beta1,3-galactosyltransferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7a815bc1b68fc2d515275c8b10e18c
https://doi.org/10.1093/glycob/cwm090
https://doi.org/10.1093/glycob/cwm090
Autor:
Sai Buddai, Francesco V. Rao, Bojana Rakic, Warren W. Wakarchuk, Stephen G. Withers, Shawn Defrees, Karl F. Johnson, Jamie R. Rich, Natalie C. J. Strynadka, Caryn Bowe, Marc F. Schwartz
Publikováno v:
Nature Structural & Molecular Biology. 16:1186-1188
Mammalian cell surfaces are modified by complex arrays of glycoproteins, glycolipids and polysaccharides, many of which terminate in sialic acid and have central roles in essential processes including cell recognition, adhesion and immunogenicity. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47bc852fc5bbc6b23165c03f3a7c8e6
https://doi.org/10.1038/nsmb.1685
https://doi.org/10.1038/nsmb.1685
Autor:
Georgios Skretas, George Georgiou, Marc F. Schwartz, Shawn Defrees, Sean M. Carroll, Karl F. Johnson
Publikováno v:
Microbial Cell Factories, Vol 8, Iss 1, p 50 (2009)
Microbial Cell Factories
Microbial Cell Factories
Background The presence of terminal, surface-exposed sialic acid moieties can greatly enhance the in vivo half-life of glycosylated biopharmaceuticals and improve their therapeutic efficacy. Complete and homogeneous sialylation of glycoproteins can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa9dfe2bf9c3dfe7ae59ebddd47fe2d
https://doi.org/10.1186/1475-2859-8-50
https://doi.org/10.1186/1475-2859-8-50
Autor:
Stephen G. Withers, and R. Antony J. Warren, Mark D. Vaughan, Karl F. Johnson, Shawn Defrees, Tang Xiaoping
Publikováno v:
Journal of the American Chemical Society. 128(19)
Glycosphingolipids play crucial roles in virtually every stage of the cell cycle, and their clinical administration has been proposed as a treatment for Alzheimer's, Parkinson's, stroke, and a range of other conditions. However, lack of supply has se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401a826acfd6fa4a20ce1b0444f9b742
https://pubmed.ncbi.nlm.nih.gov/16683778
https://pubmed.ncbi.nlm.nih.gov/16683778
Autor:
Shawn DeFrees, Zhi-Guang Wang, Ruye Xing, Arthur E. Scott, Jin Wang, David Zopf, Dominique L. Gouty, Eric R. Sjoberg, Krishnasamy Panneerselvam, Els C. M. Brinkman-Van der Linden, Robert J. Bayer, Mads A. Tarp, Henrik Clausen
Publikováno v:
Glycobiology; Sep2006, Vol. 16 Issue 9, p833-843, 11p