Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shawn D. Hingtgen"'
Autor:
Alex S. Woodell, Elisa Landoni, Alain Valdivia, Andrew Buckley, Edikan A. Ogunnaike, Gianpietro Dotti, Shawn D. Hingtgen
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 6, Pp n/a-n/a (2023)
Abstract Chimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell thera
Externí odkaz:
https://doaj.org/article/2703b17aad854d00917108d980cb7bf5
Autor:
Hunter N. Bomba, Abigail Carey‐Ewend, Kevin T. Sheets, Alain Valdivia, Morgan Goetz, Ingrid A. Findlay, Alison Mercer‐Smith, Lauren E. Kass, Simon Khagi, Shawn D. Hingtgen
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 2, Pp n/a-n/a (2022)
Abstract Induced neural stem cells (iNSCs) have emerged as a promising therapeutic platform for glioblastoma (GBM). iNSCs have the innate ability to home to tumor foci, making them ideal carriers for antitumor payloads. However, the in vivo persisten
Externí odkaz:
https://doaj.org/article/c2b623cb992f42d297503de74ed1aa7c
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2243 (2022)
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults and despite recent advances in treatment modalities, GBM remains incurable. Injectable hydrogel scaffolds are a versatile delivery system that can improve delivery of dr
Externí odkaz:
https://doaj.org/article/499cc055f95c42169f6fade94b03e011
Autor:
Hunter N. Bomba, Kevin T. Sheets, Alain Valdivia, Simon Khagi, Laura Ruterbories, Christopher L. Mariani, Luke B. Borst, Debra A. Tokarz, Shawn D. Hingtgen
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 1, Pp n/a-n/a (2021)
Abstract In this study, we take an important step toward clinical translation by generating the first canine‐induced neural stem cells (iNSCs). We explore key aspects of scale‐up, persistence, and safety of personalized iNSC therapy in autologous
Externí odkaz:
https://doaj.org/article/a38f818c20b3442cb3bef3ef71b9e4d1
Autor:
Juli R. Bagó, Adolfo Alfonso-Pecchio, Onyi Okolie, Raluca Dumitru, Amanda Rinkenbaugh, Albert S. Baldwin, C. Ryan Miller, Scott T. Magness, Shawn D. Hingtgen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shr
Externí odkaz:
https://doaj.org/article/b167638618f64960906efb2752744934
Publikováno v:
Neuro-Oncology.
Glioblastoma (GBM) is a highly aggressive tumor with a devastating impact on quality-of-life and abysmal survivorship. Patients have very limited effective treatment options. The successes of targeted small molecule drugs and immune checkpoint inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afaa8b55b431ee6b0c4f42834aa64972
https://doi.org/10.1093/neuonc/noad092
https://doi.org/10.1093/neuonc/noad092
Autor:
Shawn D. Hingtgen, Carey K. Anders, Kevin T. Sheets, Stephanie A. Montgomery, Alex S. Woodell, Morrent Thang, Alain Valdivia, Juli R. Bago, Wulin Jiang, Alison R. Mercer-Smith
Converting human fibroblasts into personalized induced neural stem cells (hiNSC) that actively seek out tumors and deliver cytotoxic agents is a promising approach for treating cancer. Herein, we provide the first evidence that intravenously-infused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becb2f068a2d90658b9b128d19bdd7f8
https://doi.org/10.1158/1535-7163.c.6543552.v1
https://doi.org/10.1158/1535-7163.c.6543552.v1
Autor:
Shawn D. Hingtgen, Carey K. Anders, Kevin T. Sheets, Stephanie A. Montgomery, Alex S. Woodell, Morrent Thang, Alain Valdivia, Juli R. Bago, Wulin Jiang, Alison R. Mercer-Smith
Supplementary Data containing Figures S1-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9550190276397bb56e04fa29bc4dbc87
https://doi.org/10.1158/1535-7163.22523016.v1
https://doi.org/10.1158/1535-7163.22523016.v1
Autor:
Alison R. Mercer-Smith, Andrew Buckley, Alain Valdivia, Wulin Jiang, Morrent Thang, Noah Bell, Rashmi J. Kumar, Hunter N. Bomba, Alex S. Woodell, Jie Luo, Scott R. Floyd, Shawn D. Hingtgen
Publikováno v:
Stem Cell Reviews and Reports. 18:2474-2493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d667e2b5546aac16e102a5a7fc1b57ae
https://doi.org/10.1007/s12015-022-10375-3
https://doi.org/10.1007/s12015-022-10375-3
Autor:
Onyinyechukwu Okolie, David M Irvin, Juli R Bago, Kevin Sheets, Andrew Satterlee, Abigail G Carey-Ewend, Vivien Lettry, Raluca Dumitru, Scott Elton, Matthew G Ewend, C Ryan Miller, Shawn D Hingtgen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0198596 (2018)
BACKGROUND:Cytotoxic neural stem cells (NSCs) have emerged as a promising treatment for Medulloblastoma (MB), the most common malignant primary pediatric brain tumor. The lack of accurate pre-clinical models incorporating surgical resection and tumor
Externí odkaz:
https://doaj.org/article/fe1ab6ed26f34583ac35dbd434ade258