Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shawn D. Britt"'
Autor:
Michael D. Connolly, Matthew J. LaMarche, Lawrence G. Hamann, Ayako Honda, Brigitte Wiedmann, Subramanian Karur, Shawn D. Britt, Markus Dobler, Rajeshri Ganesh Karki, Prakash Raman, Anup Patnaik, Samantha Sokup, Erin P. Keaney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3714-3718
Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed in genotype (
Autor:
William Markland, Ernst ter Haar, Darshana Zhaveri, Guy W. Bemis, Thomas Hoock, Martin Connors, Francesco G. Salituro, Shawn D. Britt, Cochran John E, Suganthini Nanthakumar, Edmund Harrington, Jian Wang, Luc J. Farmer, Paul Taslimi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6231-6235
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki’s against SYK and potent inhibition in mast cell degranulatio
Autor:
Cynthia A. Gates, John A. Thomson, Kevin M. Cottrell, Yu P. Luong, Scott L. Harbeson, Robert B. Perni, John H. Van Drie, David D. Deininger, Roger D. Tung, Shawn D. Britt, Chao Lin, Janos Pitlik, Luc J. Farmer, John J. Court, Yunyi Wei, John Maxwell, Kai Lin, Bhisetti Govinda Rao, Lawrence F. Courtney, Wayne C. Schairer
Publikováno v:
Letters in Drug Design & Discovery. 2:497-502
Autor:
Ethan O'malley, Yunyi Wei, Yu-Ping Luong, John H. Van Drie, Lawrence F. Courtney, Scott L. Harbeson, Janos Pitlik, Kai Lin, Roger D. Tung, Young-Choon Moon, Shawn D. Britt, Chao Lin, Luc J. Farmer, B. Govinda Rao, John J. Court, Cynthia A. Gates, John A. Thomson, David D. Deininger, Robert B. Perni, Rhonda B. Levin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1441-1446
The α-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3·4A protease inhibitors. Structure–activity relationships and prime side optimization are discussed.
Autor:
Rhonda B. Levin, Luc J. Farmer, Robert B. Perni, Joseph L. Kim, Janos Pitlik, B. Govinda Rao, J. A. Landro, Wayne C. Schairer, Roger D. Tung, Shawn D. Britt, Cynthia A. Gates, David D. Deininger, John A. Thomson, John H. Van Drie, Lawrence F. Courtney, John Court, Ethan O'malley, Scott L. Harbeson, Yu-Ping Luong, Yunyi Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4059-4063
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the