Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shawn D. Doran"'
Autor:
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoë A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike, Robert B. Innis
Publikováno v:
Journal of Nuclear Medicine. 63:1919-1924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c7d547cbcb5109418140c2b1e19428
https://doi.org/10.2967/jnumed.122.263838
https://doi.org/10.2967/jnumed.122.263838
Autor:
Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell, Douglas S. Johnson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a
Externí odkaz:
https://doaj.org/article/5dfe4a29e6af43a49ee6c24207abc513
Autor:
Shawn D. Doran, Jana Polivkova, James A. Southers, Scott W. Bagley, Kim Huard, Dilinie P. Fernando, Manthena V.S. Varma, David A. Beebe, David J. Edmonds, Robert L. Dow, Benjamin A. Thuma, Collin Crowley, William P. Esler, Trenton T. Ross, David A. Tess, Mark Niosi, Amit S. Kalgutkar, Jeffrey A. Pfefferkorn, Norimitsu Shirai, David A. Griffith, Shawn Cabral, Andrew H. Smith, Gregg D. Cappon, Vincent Mascitti, Matthew S. Dowling, Andre Shavnya, David Price, Ayman El-Kattan, Aaron C. Smith, Yi-an Bi, Spiros Liras, Xiaojing Helen Yang, Cathy Préville
Publikováno v:
Journal of Medicinal Chemistry. 63:10879-10896
Preclinical and clinical data suggest that acetyl-CoA carboxylase (ACC) inhibitors have the potential to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic steatohepatitis (NASH). Consistent with these observations, first-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07da4330450bd15b2bafcbaadc0cc94b
https://doi.org/10.1021/acs.jmedchem.0c00640
https://doi.org/10.1021/acs.jmedchem.0c00640
Autor:
Jonathan R. Heyen, Brandy Chavez, Sergei Timofeevski, Murali Gururajan, Keith A. Ching, Szu-Yu Tang, Eleanore Hendrickson, Rui Eugene Yuanjin, Shawn D. Doran, Stephanie T. Shi, Gina Chu, Christopher P. Dillon, Jennifer Kinong, Yu 'Jerry' Zhou, Jon Oyer, Andrew R. Nager, Vinayak Rayannavar, Rajarshi Bhadra, Johnni Gullo-Brown, Indrawan James Mcalpine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundP21-activated kinase 4 (PAK4) is a serine/threonine protein kinase that is mostly expressed in tumor and stroma cells. PAK4 activates tumor WNT/β-catenin pathway and regulates cellular morphology, motility, EMT, cell proliferation and surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb992a17f4468fd8accc364f85e3ea0e
https://doaj.org/article/f1d6517467594e24b8981f644a3baeab
https://doaj.org/article/f1d6517467594e24b8981f644a3baeab
Autor:
Laigao Chen, Anabella Villalobos, Ryosuke Arakawa, Shawn D. Doran, Christer Halldin, Brian T. O’Neill, Akihiro Takano, Michael Aaron Brodney, Nahid Amini, Charles E. Nolan, Timothy J. McCarthy, Jason K. Dutra, Sangram Nag, Cheng Chang, Lei Zhang
Publikováno v:
Journal of Nuclear Medicine. 60:992-997
Beta-secretase 1 (BACE1) is a key enzyme in the generation of beta-amyloid, which is accumulated in the brain of Alzheimer’s disease (AD) patients. PF-06684511 was identified as a candidate PET ligand for imaging BACE1 in the brain, and showed high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc017d72ab0f8c8c2e3e286dc6ce3d29
https://doi.org/10.2967/jnumed.118.217372
https://doi.org/10.2967/jnumed.118.217372
Autor:
Kelly R. Bales, Anabella Villalobos, David Riddell, Shawn D. Doran, Christopher Ryan Butler, Bruce N. Rogers, Lorraine F. Lanyon, Karamjeet Pandher, Claude Ambroise, Ashley Robshaw, Gabriela Barreiro, Christopher Houle, Kevin Ogilvie, Brian T. O’Neill, Erik Alphie Lachapelle, Germaine Boucher, Xinjun Hou, Katherine Hales, David Karanian, Michael Aaron Brodney, Leanne M. Buzon, Kimberly Lapham, Lei Zhang, Luis Martinez-Alsina, Charles E. Nolan, Claire M. Steppan, Cathleen Gonzales, John C. Murray, Cheng Chang, Jason K. Dutra, Elizabeth Mary Beck
Publikováno v:
Journal of Medicinal Chemistry. 61:4476-4504
A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease is the alignment of potency, drug-like properties, and selectivity over related aspartyl proteases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16220e824d55c04d1dd3342582ab393
https://doi.org/10.1021/acs.jmedchem.8b00246
https://doi.org/10.1021/acs.jmedchem.8b00246
Autor:
Nandini Chaturbhai Patel, Richard V. Coelho, Christopher John Helal, Chewah Lee, Anabella Villalobos, Shawn D. Doran, Joseph Michael Young, Robert J. Mather, Simone Sciabola, Erik Alphie Lachapelle, John T. Lazzaro, Thomas Allen Chappie, Patrick Robert Verhoest, Zoë A. Hughes, Marc B. Skaddan, Elizabeth Mary Beck, John M. Humphrey, Kyle Kuszpit, Laigao Chen, Lei Zhang, Kenneth R. Zasadny, Kuo-Hsien Fan
Publikováno v:
Journal of Medicinal Chemistry. 60:8538-8551
As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f5ba940556ef8664e507811b6fb86d
https://doi.org/10.1021/acs.jmedchem.7b01050
https://doi.org/10.1021/acs.jmedchem.7b01050
Autor:
Felix Vajdos, Eric Benvenuti, Leanne M. Buzon, Brian T. O’Neill, Gabriela Barreiro, David Riddell, Kevin Atchison, Charles E. Nolan, Ashley Robshaw, Eric F. Johnson, Kevin D. Parris, Shawn D. Doran, Michael Aaron Brodney, Xinjun Hou, Luis Martinez-Alsina, Kimberly Lapham, Mei-Hui Hsu, Elizabeth Mary Beck, Christopher Ryan Butler, Kevin Ogilvie, Cathleen Gonzales, Lorraine F. Lanyon, Christopher John Helal
Publikováno v:
Journal of Medicinal Chemistry
A growing subset of β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease (AD) utilizes an anilide chemotype that engages a key residue (Gly230) in the BACE1 binding site. Although the anilide moiety affords excellent potency, it s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded625eb28a2c9b897d6055a57557a14
https://doi.org/10.1021/acs.jmedchem.6b01451
https://doi.org/10.1021/acs.jmedchem.6b01451
Autor:
Akihiro, Takano, Laigao, Chen, Sangram, Nag, Michael A, Brodney, Ryosuke, Arakawa, Cheng, Chang, Nahid, Amini, Shawn D, Doran, Jason K, Dutra, Timothy J, McCarthy, Charles E, Nolan, Brian T, O'Neill, Anabella, Villalobos, Lei, Zhang, Christer, Halldin
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(7)
β-secretase 1 (BACE1) is a key enzyme in the generation of β-amyloid, which is accumulated in the brain of Alzheimer disease patients. PF-06684511 was identified as a candidate PET ligand for imaging BACE1 in the brain and showed high specific bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07ab8a235067dc35f919a5196244d1ca
https://pubmed.ncbi.nlm.nih.gov/30530832
https://pubmed.ncbi.nlm.nih.gov/30530832
Autor:
Charles E. Nolan, Christer Halldin, Anabella Villalobos, Kelly R. Bales, Klaas Schildknegt, Ryosuke Arakawa, Akihiro Takano, Lorraine F. Lanyon, Leanne M. Buzon, Shawn D. Doran, Nahid Amini, Laigao Chen, Brian T. O’Neill, Michael Aaron Brodney, Elizabeth Mary Beck, Lei Zhang, Timothy J. McCarthy, Sangram Nag, Jason K. Dutra
Publikováno v:
Journal of medicinal chemistry. 61(8)
Alzheimer’s disease (AD) is characterized by accumulation of β-amyloid (Aβ) plaques and neurofibrillary tau tangles in the brain. β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) plays a key role in the generation of Aβ fragments via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087651e6e72808da07b8c041e1b3d37c
https://pubmed.ncbi.nlm.nih.gov/29617136
https://pubmed.ncbi.nlm.nih.gov/29617136