Výsledky vyhledávání - "Shawn Brisbay"

Evidence That Transfer of Functional p53 Protein Results in Increased Apoptosis in Prostate Cancer

Autor: Christopher G. Wood, Kim Anh Do, E. Hossan, L. Clifton Stephens, Timothy J. McDonnell, Robert B. Evans, Christopher J. Logothetis, Xuemei Wang, James A. Merritt, Shawn Brisbay, Cindy Soto, Marc G. Jacobson, Patricia Troncoso, Curtis A. Pettaway, Karen Parker, Mitchell S. Steiner, Louis L. Pisters

Publikováno v: Clinical Cancer Research. 10:2587-2593

Purpose: INGN 201 (Ad-p53) is a replication-defective adenoviral vector that encodes a wild-type p53 gene driven by the cytomegalovirus promoter. INGN 201 has been shown to have antitumoral activity against human prostate cancer cell lines. This stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42770e8deffe30c361da140f9f38ffb
https://doi.org/10.1158/1078-0432.ccr-03-0388

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Molecular determinants of cell death induction following adenovirus‐mediated gene transfer of wild‐type p53 in prostate cancer cells

Autor: Shawn Brisbay, Alexander W. Beham, Jack A. Roth, Guido Schumacher, Elizabeth M. Bruckheimer, Tsuyoshi Honda, Timothy J. McDonnell, Christopher J. Logothetis

Publikováno v: International Journal of Cancer. 91:159-166

Adenoviral vectors expressing wild-type p53 (Ad-p53) induce apoptosis in different types of cancer cells. The therapeutic utility of Ad-p53 is now being evaluated in prostate-cancer patients. Bcl-2 is frequently expressed by prostate-cancer cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14a841f91453067892275df793dd93e8
https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1026>3.3.co

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Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer

Autor: H B S Song Cho, Mona Sarkiss, B S Shawn Brisbay, and Adel K. El-Naggar M.D., Timothy J. McDonnell, B S Michael Davies, Maryse Delehedde

Publikováno v: Cancer. 85:1514-1522

BACKGROUND Differentiation, proliferation, and cell death are coordinated tightly within the epidermis. Alterations within keratinocytes that disrupt these processes are believed to contribute to the development of nonmelanoma skin cancers (NMSC). In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d97f4453a3b9f227c53b72b45a60d5d2
https://doi.org/10.1002/(sici)1097-0142(19990401)85:7<1514::aid-cncr12>3.0.co

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Bcl-2 inhibits p53 nuclear import following DNA damage

Autor: Alexander Beham, John L. Herrmann, Gabriel Lopez-Berestein, Mona Sarkiss, Shawn Brisbay, Ana M. Tari, Timothy J. McDonnell, Guillermina Lozano, Maria C. Marin, Antonio Fernandez

Publikováno v: Oncogene. 15:2767-2772

Bcl-2 is an integral membrane oncoprotein that localizes to membranes of the mitochondria, endoplasmic reticulum, and nuclear envelope. Bcl-2 is a member of a family of cell death regulators and functions to inhibit apoptosis. Using confocal microsco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b690ab93c4a73a9bdbccb9df6de5aa2
https://doi.org/10.1038/sj.onc.1201464

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Expression of BCL-2 Oncoprotein and P53 Protein Accumulation in Bone Marrow Metastases of Androgen Independent Prostate Cancer

Autor: Timothy J. McDonnel, Patricia Troncoso, Nora M. Navone, Claudio J. Conti, Andrew C. von Eschenbach, Louis L. Pisters, Christopher J. Logothetis, Shawn Brisbay

Publikováno v: Journal of Urology. 157:569-574

Purpose: We correlated the expression of bcl-2 with accumulation of p53 protein in bone marrow metastases from patients with androgen independent prostate cancer and a history of hormonal ablation therapy. These results were correlated with clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a90682cf643d0cc2cee29f3468a3fc
https://doi.org/10.1016/s0022-5347(01)65204-2

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The Expression and Localization of bcl-2 Protein in Normal Skin and in Non-Melanoma Skin Cancers

Autor: Julio Rodriguez-Villanueva, Shawn Brisbay, T.J. McDonnell, M.I. Colome

Publikováno v: Pathology - Research and Practice. 191:391-398

Summary Non-melanoma skin cancers are the most commonly diagnosed malignancies and are typically indolent in their clinical behavior. Although predisposing factors leading to the development of these cancers, such as ultraviolet irradiation, are well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b1982afedd2624843a162c3a291701
https://doi.org/10.1016/s0344-0338(11)80724-7

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Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer

Autor: George Prendergast, Jeong Hee Cho-Vega, Timothy J. McDonnell, Patricia Troncoso, Carlos E. Bueso-Ramos, Remigio Lopez, Nikhil S. Chari, Xuemei Wang, Kim Anh Do, Kevin R. Coombes, Shawn Brisbay, Christopher J. Logothetis

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 1, Iss 1, p 1 (2008)

Background: The early detection of prostate cancer has resulted in an increase in the number of patients with localized prostate cancer and has paralleled the reported reduction in prostate cancer mortality. The increased rate of detection of patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515ff56eae57b694342b933fcb8c0728
https://pubmed.ncbi.nlm.nih.gov/18237448

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Clinical and biomarker correlates of androgen-independent, locally aggressive prostate cancer with limited metastatic potential

Autor: Remigio Lopez, Kim Anh Do, Christos N. Papandreou, Xuemei Wang, Christopher J. Logothetis, Vasily J. Assikis, Jeong Hee Cho-Vega, Sijin Wen, Timothy J. McDonnell, Patricia Troncoso, Shawn Brisbay

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 10(20)

Purpose: We have identified a subset of patients exhibiting extended survival with metastases from androgenindependent prostate cancer of which the principal site of progression was the tumor primary. The purpose of this study was to evaluate the exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d24b08e3a2cdde460d38128efe79f1
https://pubmed.ncbi.nlm.nih.gov/15501953

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