Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shawn Beug"'
Autor:
Sakie Katsumura, Nahum Sonenberg, Sang-Ging Ong, Soroush Tahmasebi, Sung-Hoon Kim, Nathaniel Robichaud, Hamza Ali, Xu Zhang, Dana Pearl, Xinhe Pang, Mehdi Amiri, Jian Jun Jia, Maritza Jaramillo, Shawn Beug, Michel L. Tremblay, Negar Tabatabaei, Valerie Vinette, Laura M. Jones, Masahiro Morita, Tommy Alain
Publikováno v:
The Journal of Immunology. 204:2392-2400
Deregulation of mRNA translation engenders many human disorders, including obesity, neurodegenerative diseases, and cancer, and is associated with pathogen infections. The role of eIF4E-dependent translational control in macrophage inflammatory respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70c2b9eae13b0f6017a85cd69d0872c0
https://doi.org/10.4049/jimmunol.1900538
https://doi.org/10.4049/jimmunol.1900538
Publikováno v:
Cells
Cells, Vol 10, Iss 2672, p 2672 (2021)
Cells, Vol 10, Iss 2672, p 2672 (2021)
Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens. Unsurprisingly, this process becomes critical in supporting cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc901e62b22e1a2b65bd363626f0d568
https://pubmed.ncbi.nlm.nih.gov/34685652
https://pubmed.ncbi.nlm.nih.gov/34685652
Autor:
Stephanie J. Pichette, Janelle Holbrook, Eric C. LaCasse, Shawn Beug, Robert G. Korneluk, Martine St-Jean, Danielle E. Walker
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 10, Iss, Pp 28-39 (2018)
Molecular Therapy: Oncolytics, Vol 10, Iss, Pp 28-39 (2018)
Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs syne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e49c6e17795853122f5f084351e62a7
http://europepmc.org/articles/PMC6076221
http://europepmc.org/articles/PMC6076221
Autor:
Robert G. Korneluk, Herman H. Cheung, Stephen Baird, Martine St-Jean, Eric C. LaCasse, Caroline E. Beauregard, Tarun Sanda, Shawn Beug, Hapsatou Mamady
Publikováno v:
Science Signaling. 12
The controlled production and downstream signaling of the inflammatory cytokine tumor necrosis factor-α (TNF-α) are important for immunity and its anticancer effects. Although chronic stimulation with TNF-α is detrimental to the health of the host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd83b12a9ea70ccf81bcba205d600446
https://doi.org/10.1126/scisignal.aat9563
https://doi.org/10.1126/scisignal.aat9563
Autor:
Donna L. Senger, Tommy Alain, Peter Staeheli, Aditya Mohan, Robert G. Korneluk, Janelle Chabot, Caroline E. Beauregard, Nathalie Earl, Cristin Healy, Tarun Sanda, Shawn Beug, Martine St-Jean, Peter A. Forsyth, Stephen M. Robbins, Eric C. LaCasse, Danielle E. Walker, Xueqing Lun
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64da3f5137590ca94af230a459d680c5
https://doi.org/10.1038/ncomms16231
https://doi.org/10.1038/ncomms16231
Autor:
Chantal Mazerolle, Valerie A. Wallace, Erin A. Bassett, Jimmy Peng, Randy Ringuette, Shawn Beug, Philip E. B. Nickerson, Annabel Christ, Carlos R. Morales, Fadumo A. Jama, Charles Campbell
Publikováno v:
Journal of cell science. 129(20)
Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the ER to generate the biologically active amino-terminal ShhN fragment, which is destined for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5dcd1ec1e938d9dec5991ad72863ee
https://pubmed.ncbi.nlm.nih.gov/27632999
https://pubmed.ncbi.nlm.nih.gov/27632999
Publikováno v:
Development Genes and Evolution. 216:499-509
Extracellular proteases and their inhibitors may regulate a number of important processes involved in forelimb regeneration in the adult newt, including epithelial remodeling, breakdown of extracellular matrix, and dedifferentiation. We have identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891896cebdee684536bbc4ffddddc266
https://doi.org/10.1007/s00427-006-0061-z
https://doi.org/10.1007/s00427-006-0061-z
Publikováno v:
Developmental Dynamics. 235:711-722
Red-spotted newts are capable of regenerating various structures and organs through the process of epimorphic regeneration. Receptor tyrosine kinases (RTKs) and their ligands are important for normal cellular development and physiology but most have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd3a37c4978e05a52e2324c92fc6c56
https://doi.org/10.1002/dvdy.20690
https://doi.org/10.1002/dvdy.20690
Publikováno v:
The International Journal of Developmental Biology. 49:833-842
The red-spotted newt has the ability to fully regenerate complex structures by creating a pool of dedifferentiated cells that arise in response to tissue injury. An understanding of the mechanisms involved in the regenerative ability of the newt is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af831a95a6f00c0fe43b47ab6bb669dd
https://doi.org/10.1387/ijdb.052069sv
https://doi.org/10.1387/ijdb.052069sv
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 233(2)
Epimorphic limb regeneration in the adult newt involves the dedifferentiation of differentiated cells to yield a pluripotent blastemal cell. These mesenchymal-like cells proliferate and subsequently respond to patterning and differentiation cues to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10ffdaa0c070d5a8bc8cccf29313212
https://pubmed.ncbi.nlm.nih.gov/15789445
https://pubmed.ncbi.nlm.nih.gov/15789445