Výsledky vyhledávání - "Shawn, Zhang"

Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study

Autor: Shawn Zhang, Karthik Nagapudi, Mike Shen, Joshua Lomeo, Yuri Qin, Aiden Zhu, Purnendu Nayak, Debby Chang, Rami N. Hannoush

Publikováno v: Journal of Pharmaceutical Sciences. 111:1896-1910

The development of long-acting drug formulations requires efficient characterization technique as the designed 6-12 months release duration renders real-time in vitro and in vivo experiments cost and time prohibitive. Using a novel image-based releas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac56ac1b9c016d9b1618b73a6dc60669
https://doi.org/10.1016/j.xphs.2021.12.009

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Assessing the Interrelationship of Microstructure, Properties, Drug Release Performance, and Preparation Process for Amorphous Solid Dispersions Via Noninvasive Imaging Analytics and Material Characterization

Autor: Wei Jia, Phillip D. Yawman, Keyur M. Pandya, Kellie Sluga, Tania Ng, Dawen Kou, Karthik Nagapudi, Paul E. Luner, Aiden Zhu, Shawn Zhang, Hao Helen Hou

Publikováno v: Pharmaceutical Research. 39:3137-3154

The purpose of this work is to evaluate the interrelationship of microstructure, properties, and dissolution performance for amorphous solid dispersions (ASDs) prepared using different methods.ASD of GDC-0810 (50% w/w) with HPMC-AS was prepared using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e731878341a27a4bc00f86ef93b51c5b
https://doi.org/10.1007/s11095-022-03308-9

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Abstract 3997: Preclinical characterization of ARX517, a next-generation anti-PSMA antibody drug conjugate for the treatment of metastatic castration-resistant prostate cancer

Autor: Lillian Skidmore, David Mills, Ji Young Kim, Prathap Shastri, Nick A. Knudsen, Jeff Steen, Jay Nelson, Ying Buechler, Feng Tian, Shawn Zhang

Publikováno v: Cancer Research. 83:3997-3997

Prostate cancer is the most common cancer, and the second leading cause of cancer death, among men in the United States. Metastatic castration-resistant prostate cancer (mCRPC) is an advanced stage of disease in which patients ultimately fail androge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b9fb9bee3440d6938bcee16c385557e
https://doi.org/10.1158/1538-7445.am2023-3997

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Semisolid Pharmaceutical Product Characterization Using Non-invasive X-ray Microscopy and AI-Based Image Analytics

Autor: Thean, Yeoh, Lisa, Ma, Abu Zayed, Badruddoza, Jaymin, Shah, Shawn, Zhang

Publikováno v: The AAPS Journal. 24

This work reports the use of X-ray microscopy (XRM) imaging to characterize the microstructure of semisolid formulations containing multiple immiscible phases. For emulsion-based semisolid formulations, the disperse phase globule size and its distrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdf659d9b78078ef0a408bd4a40bf79
https://doi.org/10.1208/s12248-022-00696-z

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Assessing microstructural critical quality attributes in PLGA microspheres by FIB-SEM analytics

Autor: Andrew G. Clark, Ruifeng Wang, Yuri Qin, Yan Wang, Aiden Zhu, Joshua Lomeo, Quanying Bao, Diane J. Burgess, Jacie Chen, Bin Qin, Yuan Zou, Shawn Zhang

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 349

The distribution of the active pharmaceutical ingredient (API) within polymer-based controlled release drug products is a critical quality attribute (CQA). It is crucial for the development of such products, to be able to accurately characterize phas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00c999d3b7607aa7a81be4e541c8ee4
https://pubmed.ncbi.nlm.nih.gov/35803326

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