Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Shaw M, Akula"'
Autor:
Anais N. Bauer, John F. Williams, Lok R. Pokhrel, Selena Garcia, Niska Majumdar, Jeffrey B. Eells, Paul P. Cook, Shaw M. Akula
Publikováno v:
Toxics, Vol 12, Iss 7, p 495 (2024)
Smart Nano-enabled Antiviral Therapeutic (SNAT) is a promising nanodrug that previously demonstrated efficacy in preclinical studies to alleviate SARS-CoV-2 pathology in hamsters. SNAT comprises taxoid (Tx)-decorated amino (NH2)-functionalized near-a
Externí odkaz:
https://doaj.org/article/c47b1d18a2a84e449a24de4c0ccf75b1
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract To tackle growing antibiotic resistance (AR) and hospital-acquired infections (HAIs), novel antimicrobials are warranted that are effective against HAIs and safer for human use. We hypothesize that small 5 nm size positively charged nanopart
Externí odkaz:
https://doaj.org/article/232e0181ee9841d7b0802dd83038a4c4
Autor:
Anais N. Bauer, Niska Majumdar, Frank Williams, Smit Rajput, Lok R. Pokhrel, Paul P. Cook, Shaw M. Akula
Publikováno v:
Biology, Vol 12, Iss 10, p 1334 (2023)
Since the discovery of microRNAs (miRNAs) in C. elegans in 1993, the field of miRNA research has grown steeply. These single-stranded non-coding RNA molecules canonically work at the post-transcriptional phase to regulate protein expression. miRNAs a
Externí odkaz:
https://doaj.org/article/f8b5c5077f6d44299c7fa49eb1b6b2c5
Autor:
Srinivas Sriramula, Drew Theobald, Rohan Umesh Parekh, Shaw M. Akula, Dorcas P. O’Rourke, Jeffrey B. Eells
Publikováno v:
Cells, Vol 12, Iss 16, p 2107 (2023)
Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible f
Externí odkaz:
https://doaj.org/article/b096f5a9535e4aeba4de0c02d3907963
Publikováno v:
Viruses, Vol 14, Iss 12, p 2681 (2022)
Wide variability exists with host response to SARS-CoV-2 infection among individuals. Circulatory micro RNAs (miRNAs) are being recognized as promising biomarkers for complex traits, including viral pathogenesis. We hypothesized that circulatory miRN
Externí odkaz:
https://doaj.org/article/a63722b576b94be2906936975472414f
Autor:
Stephen L. Abrams, Przemysław Duda, Shaw M. Akula, Linda S. Steelman, Matilde L. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppe Montalto, Maria Rita Emma, Melchiorre Cervello, Dariusz Rakus, Agnieszka Gizak, James A. McCubrey
Publikováno v:
Cells, Vol 11, Iss 5, p 794 (2022)
The TP53 tumor suppressor is mutated in ~75% of pancreatic cancers. The mutant TP53 protein in pancreatic ductal adenocarcinomas (PDAC) promotes tumor growth and metastasis. Attempts have been made to develop molecules that restore at least some of t
Externí odkaz:
https://doaj.org/article/b88503daf256434e9d204e634e50ec26
Autor:
Richard J. Smeyne, Jeffrey B. Eells, Debotri Chatterjee, Matthew Byrne, Shaw M. Akula, Srinivas Sriramula, Dorcas P. O'Rourke, Peter Schmidt
Publikováno v:
Movement Disorders. 37:1394-1404
Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the systemic responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5267287543e8d8c9d48b86bb97fbdd0c
https://doi.org/10.1002/mds.29116
https://doi.org/10.1002/mds.29116
Autor:
Stephen L. Abrams, Shaw M. Akula, Akshaya K. Meher, Linda S. Steelman, Agnieszka Gizak, Przemysław Duda, Dariusz Rakus, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Giuseppe Montalto, Melchiorre Cervello, Peter Ruvolo, Massimo Libra, Luca Falzone, Saverio Candido, James A. McCubrey
Publikováno v:
Cells, Vol 10, Iss 4, p 816 (2021)
Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link betwee
Externí odkaz:
https://doaj.org/article/40c21af23bd74ea8a11c56b197a2955e
Autor:
James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemysław Duda, Agnieszka Gizak
Publikováno v:
Aging. 14:3365-3386
TP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair, drug resistance, malignant transformation, metastasis, and metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edd25c24fbd50ad712ed6ca3b0705ab
https://doi.org/10.18632/aging.204038
https://doi.org/10.18632/aging.204038
Publikováno v:
Drug Delivery and Translational Research. 12:3007-3016
To address the unprecedented global public health crisis due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we designed and developed a novel antiviral nano-drug, called SNAT (Smart Nano-Enabled Antiviral Therapeutic), comprised of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e24a4d8e796df6466cd518a5d3ea4f1
https://doi.org/10.1007/s13346-022-01166-x
https://doi.org/10.1007/s13346-022-01166-x