Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort

Autor: Simuni, T, Merchant, K, Brumm, MC, Cho, H, Caspell-Garcia, C, Coffey, CS, Chahine, LM, Alcalay, RN, Nudelman, K, Foroud, T, Mollenhauer, B, Siderowf, A, Tanner, C, Iwaki, H, Sherer, T, Marek, K, Seibyl, J, Coffey, C, Tosun-Turgut, D, Shaw, LM, Trojanowski, JQ, Singleton, A, Kieburtz, K, Toga, A, Galasko, D, Poewe, W, Poston, K, Bressman, S, Reimer, A, Arnedo, V, Clark, A, Frasier, M, Kopil, C, Chowdhury, S, Casaceli, C, Dorsey, R, Wilson, R, Mahes, S, Salerno, C, Ahrens, M, Brumm, M, Cho, HR, Fedler, J, LaFontant, D-E, Kurth, R, Crawford, K, Casalin, P, Malferrari, G, Weisz, MG, Orr-Urtreger, A, Trojanowski, J, Shaw, L, Montine, T, Baglieri, C, Christini, A, Russell, D, Dahodwala, N, Giladi, N, Factor, S, Hogarth, P, Standaert, D, Hauser, R, Jankovic, J, Saint-Hilaire, M, Richard, I, Shprecher, D, Fernandez, H, Brockmann, K, Rosenthal, L, Barone, P, Espayc, A, Rowe, D, Marder, K, Santiago, A, Hu, S-C, Isaacson, S, Corvol, J-C, Martinez, JR, Tolosa, E, Tai, Y, Politis, M, Smejdir, D, Rees, L, Williams, K, Kausar, F, Richardson, W, Willeke, D, Peacock, S, Sommerfeld, B, Freed, A, Wakeman, K, Blair, C, Guthrie, S, Harrell, L, Hunter, C, Thomas, C-A, James, R, Zimmerman, G, Brown, V, Mule, J, Hilt, E, Ribb, K, Ainscough, S, Wethington, M, Ranola, M, Santana, HM, Moreno, J, Raymond, D, Speketer, K, Carvajal, L, Carvalo, S, Croitoru, I, Garrido, A, Payne, LM, Viswanth, V, Severt, L, Facheris, M, Soares, H, Mintun, MA, Cedarbaum, J, Taylor, P, Biglan, K, Vandenbroucke, E, Sheikh, ZH, Bingol, B, Fischer, T, Sardi, P, Forrat, R, Reith, A, Egebjerg, J, Hillert, GA, Saba, B, Min, C, Umek, R, Mather, J, De Santi, S, Post, A, Boess, F, Taylor, K, Grachev, I, Avbersek, A, Muglia, P, Tauscher, J

We examined 2-year longitudinal change in clinical features and biomarkers in LRRK2 non-manifesting carriers (NMCs) versus healthy controls (HCs) enrolled in the Parkinson’s Progression Markers Initiative (PPMI). We analyzed 2-year longitudinal dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::57cb78cbdcff5c5771194646efb11352
http://hdl.handle.net/10044/1/101202

DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples

Autor: Shaw, LM, Blanchard, A, Chen, Q, An, X, Totemeyer, S, Zhu, Y-G, Stekel, DJ

High throughput genomics technologies are applied widely to microbiomes in humans, animals, soil and water, to detect changes in bacterial communities or the genes they carry, between different environments or treatments. We describe a method to test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::07bc6fa9d73daecda8fb08242dd80e9d
https://irep.ntu.ac.uk/id/eprint/35577/1/13423_Blanchard.pdf

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Autor: Lewczuk, P, Riederer, P, O'Bryant, SE, Verbeek, MM, Dubois, B, Visser, PJ, Jellinger, KA, Engelborghs, S, Ramirez, A, Parnetti, L, Jack, CR, Teunissen, CE, Hampel, H, Lleo, A, Jessen, F, Glodzik, L, de Leon, MJ, Fagan, AM, Molinuevo, JL, Jansen, WJ, Winblad, B, Shaw, LM, Andreasson, U, Otto, M, Mollenhauer, B, Wiltfang, J, Turner, MR, Zerr, I, Handels, R, Thompson, AG, Johansson, G, Ermann, N, Trojanowski, JQ, Karaca, I, Wagner, H, Oeckl, P, van Doorn, LV, Bjerke, M, Kapogiannis, D, Kuiperij, HB, Farotti, L, Li, Y, Gordon, BA, Epelbaum, S, Vos, SJB, Klijn, CJM, Van Nostrand, WE, Minguillon, C, Schmitz, M, Gallo, C, Mato, AL, Thibaut, F, Lista, S, Alcolea, D, Zetterberg, H, Blennow, K, Kornhuber, J, WFSBP Task Force

Publikováno v: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
The world journal of biological psychiatry 19(4), 244-328 (2017). doi:10.1080/15622975.2017.1375556
Lewczuk, P, O’Bryant, S E, Verbeek, M M, Dubois, B, Visser, P J, Jellinger, K A, Engelborghs, S, Ramirez, A, Parnetti, L, Jack, C R, Teunissen, C E, Hampel, H, Lleó, A, Jessen, F, Glodzik, L, de Leon, M J, Fagan, A M, Molinuevo, J L, Jansen, W J, Winblad, B, Shaw, L M, Andreasson, U, Otto, M, Mollenhauer, B, Wiltfang, J, Turner, M R, Zerr, I, Handels, R, Thompson, A G, Johansson, G, Ermann, N, Trojanowski, J Q, Karaca, I, Wagner, H, Oeckl, P, van Waalwijk van Doorn, L, Bjerke, M, Kuiperij, H B, Farotti, L, Li, Y, Gordon, B A, Epelbaum, S, Vos, S J B, Klijn, C J M, Van Nostrand, W E, Minguillon, C, Schmitz, M & on Behalf of the Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut 2018, ' Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias : An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry ', World Journal of Biological Psychiatry, vol. 19, no. 4, pp. 244-328 . https://doi.org/10.1080/15622975.2017.1375556
World journal of biological psychiatry
World Journal of Biological Psychiatry, 19, 244-328
World Journal of Biological Psychiatry, 19, 4, pp. 244-328

In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the ori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229c0c87fbb9a9f4317a911b71ed52e6
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3677

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

Autor: Risacher, SL, McDonald, BC, Tallman, EF, West, JD, Farlow, MR, Unverzagt, FW, Gao, S, Boustani, M, Crane, PK, Petersen, RC, Jack, CR, Jagust, WJ, Aisen, PS, Weiner, MW, Saykin, AJ, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Morris, J, Shaw, LM, Khachaturian, Z, Sorensen, G, Carrillo, M, Kuller, L, Raichle, M, Paul, S, Davies, P, Fillit, H, Hefti, F, Holtzman, D, Mesulam, MM, Potter, W, Snyder, PJ, Schwartz, A, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Balasubramanian, AB, Mason, J, Sim, I, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, DeCarli, C, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Householder, E, Taylor-Reinwald, L, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S

Publikováno v: Risacher, SL; McDonald, BC; Tallman, EF; West, JD; Farlow, MR; Unverzagt, FW; et al.(2016). Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults. JAMA Neurology, 73(6), 721-732. doi: 10.1001/jamaneurol.2016.0580. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/84q824kc

Copyright 2016 American Medical Association. All rights reserved. IMPORTANCE The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::badfa7249e83b2cf2cdfd18a7c17512d
http://www.escholarship.org/uc/item/84q824kc

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding

Autor: Lazaris, A, Hwang, KS, Goukasian, N, Ramirez, LM, Eastman, J, Blanken, AE, Teng, E, Gylys, K, Cole, G, Saykin, AJ, Shaw, LM, Trojanowski, JQ, Jagust, WJ, Weiner, MW, Apostolova, LG

Publikováno v: Lazaris, A; Hwang, KS; Goukasian, N; Ramirez, LM; Eastman, J; Blanken, AE; et al.(2015). Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurology: Genetics, 1(3), e22. doi: 10.1212/NXG.0000000000000022. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7b18t5fc

© 2015 American Academy of Neurology. Objective: We investigated the association between apoE protein plasma levels and brain amyloidosis and the effect of the top 10 Alzheimer disease (AD) risk genes on this association. Methods: Our dataset consis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6882a2ddb1084fbbcf06d598a12914e1
http://www.escholarship.org/uc/item/7b18t5fc