Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer and Lewy body disease.

Autor: Duong MT; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Das SR; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Khandelwal P; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Lyu X; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Xie L; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., McGrew E; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Dehghani N; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., McMillan CT; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lee EB; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Shaw LM; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Yushkevich PA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wolk DA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Nasrallah IM; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.

Head-to-head comparison of leading blood tests for Alzheimer's disease pathology.

Autor: Schindler SE; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Petersen KK; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Saef B; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Tosun D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Shaw LM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Zetterberg H; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute Fluid Biomarkers Laboratory, UK DRI at UCL, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Dage JL; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Ferber K; Biogen, Biomarkers Group, Cambridge, Massachusetts, USA., Triana-Baltzer G; Neuroscience Biomarkers, Johnson and Johnson Innovative Medicine, San Diego, California, USA., Du-Cuny L; AbbVie, Ludwigshafen am Rhein, Rheinland-Pfalz, Germany., Li Y; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Coomaraswamy J; Takeda Pharmaceutical Company Ltd., Cambridge, Massachusetts, USA., Baratta M; Takeda Pharmaceutical Company Ltd., Cambridge, Massachusetts, USA., Mordashova Y; AbbVie, Ludwigshafen am Rhein, Rheinland-Pfalz, Germany., Saad ZS; Neuroscience Biomarkers, Johnson and Johnson Innovative Medicine, San Diego, California, USA., Raunig DL; Takeda Pharmaceutical Company Ltd., Cambridge, Massachusetts, USA., Ashton NJ; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Banner Alzheimer's Institute, Phoenix, Arizona, USA.; Banner Sun Health Research Institute, Sun City, Arizona, USA., Meyers EA; Alzheimer's Association, Chicago, Illinois, USA., Rubel CE; Biogen, Biomarkers Group, Cambridge, Massachusetts, USA., Rosenbaugh EG; The Foundation for the National Institutes of Health, North Bethesda, Maryland, USA., Bannon AW; AbbVie, North Chicago, Illinois, USA., Potter WZ; Highly qualified expert, Philadelphia, Pennsylvania, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 8074-8096. Date of Electronic Publication: 2024 Oct 12.

Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.

Autor: Liu S; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Park T; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Krüger DM; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Pena-Centeno T; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Burkhardt S; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Schutz AL; Research Group for Genome Dynamics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Huang YN; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Rosewood T; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Chaudhuri S; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Cho M; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Risacher SL; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Wan Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shaw LM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sananbenesi F; Research Group for Genome Dynamics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Brodsky AS; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA., Lin H; Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA., Krunic A; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Blusztajn JK; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Saykin AJ; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Delalle I; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Fischer A; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department for Psychiatry and Psychotherapy, University Medical Center of Göttingen, Georg-August University, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; German Center for Cardiovascular Diseases (DZHK), Göttingen, Germany., Nho K; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 7698-7714. Date of Electronic Publication: 2024 Sep 18.

The ADNI4 Digital Study: A novel approach to recruitment, screening, and assessment of participants for AD clinical research.

Autor: Miller MJ; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Diaz A; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Conti C; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Albala B; Department Environmental & Occupational Health, Public Health, University of California Irvine, Irvine, California, USA.; Department of Neurology, University of California Irvine School of Medicine, Irvine, California, USA.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy & Pharmaceutical Sciences, Irvine, California, USA.; Research Service, Veterans Administration Long Beach Healthcare System, Long Beach, California, USA., Flenniken D; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Fockler J; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Kwang W; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Sacrey DT; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Ashford MT; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Skirrow C; Novoic Ltd., London, UK., Weston J; Novoic Ltd., London, UK., Fristed E; Novoic Ltd., London, UK., Farias ST; Department of Neurology, University of California, Davis, Davis, California, USA., Korecka M; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Wan Y; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Aisen PS; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA., Beckett L; Department of Public Health Sciences, University of California, Davis, California, USA., Harvey D; Department of Public Health Sciences, University of California, Davis, California, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Shaw LM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Okonkwo OC; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Mindt MR; Departments of Psychology, Latin American Latinx Studies Institute, and African and African American Studies, Fordham University, New York, New York, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Weiner MW; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Nosheny RL; Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.; VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Oct; Vol. 20 (10), pp. 7232-7247. Date of Electronic Publication: 2024 Sep 01.

The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study.

Autor: Ashton NJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; King's College London, Institute of Psychiatry, Psychology and Neuroscience Maurice Wohl Institute Clinical Neuroscience Institute London, UK.; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation London, UK.; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway., Keshavan A; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Brum WS; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Andreasson U; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Arslan B; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Droescher M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany., Barghorn S; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany., Vanbrabant J; ADx NeuroSciences N.V., Technologiepark 6, 9052 Ghent, Belgium., Lambrechts C; ADx NeuroSciences N.V., Technologiepark 6, 9052 Ghent, Belgium., Van Loo M; ADx NeuroSciences N.V., Technologiepark 6, 9052 Ghent, Belgium., Stoops E; ADx NeuroSciences N.V., Technologiepark 6, 9052 Ghent, Belgium., Iyengar S; Alamar Biosciences, Inc., Fremont, CA, USA., Ji H; Alamar Biosciences, Inc., Fremont, CA, USA., Xu X; Alamar Biosciences, Inc., Fremont, CA, USA., Forrest-Hay A; Alamar Biosciences, Inc., Fremont, CA, USA., Zhang B; Alamar Biosciences, Inc., Fremont, CA, USA., Luo Y; Alamar Biosciences, Inc., Fremont, CA, USA., Jeromin A; ALZpath Inc., Carlsbad, CA, USA., Vandijck M; Fujirebio Europe N.V., Ghent, Belgium., Bastard NL; Fujirebio Europe N.V., Ghent, Belgium., Kolb H; Enigma Biomedical Group, CA, USA., Triana-Baltzer G; Neuroscience Biomarkers, Janssen Research and Development, La Jolla, California, USA., Bali D; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund 22184, Sweden., Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund 22184, Sweden., Yang SY; MagQu Co., Ltd., New Taipei City 112, Taiwan., Demos C; Meso Scale Diagnostics, LLC., Rockville, Maryland, USA., Romero D; Meso Scale Diagnostics, LLC., Rockville, Maryland, USA., Sigal G; Meso Scale Diagnostics, LLC., Rockville, Maryland, USA., Wohlstadter J; Meso Scale Diagnostics, LLC., Rockville, Maryland, USA., Malyavantham K; Quanterix Corp, Billerica, MA, USA., Khare M; Quanterix Corp, Billerica, MA, USA., Jethwa A; Roche Diagnostics GmbH, Penzberg, Germany., Stoeckl L; Roche Diagnostics GmbH, Penzberg, Germany., Gobom J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Kac PR; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Gonzalez-Ortiz F; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Montoliu-Gaya L; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund 22184, Sweden.; Memory Clinic, Skåne University Hospital, Malmö 20502, Sweden., Rissman RA; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, CA 92121, USA., Carillo MC; Division of Medical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA., Shaw LM; Department of pathology & laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Memory Clinic, Skåne University Hospital, Malmö 20502, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P.R. China., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute, University College London, London, UK., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Memory Clinic, Skåne University Hospital, Malmö 20502, Sweden.; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Science Park, Hong Kong, China.; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 22. Date of Electronic Publication: 2024 Aug 22.