Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shaunna L. Beedie"'
Autor:
Megan L. Peach, Shaunna L. Beedie, Cindy H. Chau, Matthew K. Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H. Greig, Michael Gütschow, Neil Vargesson, Marc C. Nicklaus, William D. Figg
Publikováno v:
Molecules, Vol 25, Iss 23, p 5683 (2020)
Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this s
Externí odkaz:
https://doaj.org/article/2a02b187b1e042829aa92879bfe598b3
Autor:
Emily M. Harris, Jonathan D. Strope, Shaunna L. Beedie, Phoebe A. Huang, Andrew K. L. Goey, Kristina M. Cook, Christopher J. Schofield, Cindy H. Chau, Melissa M. Cadelis, Brent R. Copp, Kirk R. Gustafson, William D. Figg
Publikováno v:
Marine Drugs, Vol 16, Iss 7, p 241 (2018)
Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism
Externí odkaz:
https://doaj.org/article/d95ebade53c845c4a7d6092fce254125
Autor:
Neil Vargesson, Nigel H. Greig, Marc C. Nicklaus, Matthew K Collins, Christian Steinebach, Weiming Luo, Michael Gütschow, Suzana Markolovic, David Tweedie, Shaunna L. Beedie, Cindy H. Chau, William D. Figg, Megan L. Peach
Publikováno v:
Molecules
Volume 25
Issue 23
Molecules, Vol 25, Iss 5683, p 5683 (2020)
Volume 25
Issue 23
Molecules, Vol 25, Iss 5683, p 5683 (2020)
Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this s
Autor:
Neil Vargesson, William D. Figg, Emily M Harris, Jonathan D. Strope, Cindy H. Chau, Shaunna L. Beedie, Phoebe A. Huang, Christopher B. Mahony
Publikováno v:
FASEB J
Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of immunomodulatory agents (IMiDs). CRBN is responsible for the pleiotropic effects of IMiDs, yet its function in angiogenesis and
Publikováno v:
Reproductive Toxicology. 70:49-59
The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This
Autor:
Neha Korde, Sham Mailankody, Ola Landgren, Dickran Kazandjian, Sheryl Gere, Shaunna L. Beedie, William D. Figg, Phoebe A. Huang, Cindy H. Chau, David Venzon
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Carfilzomib-lenalidomide-dexamethasone (KRd) therapy has yielded promising results in patients with newly diagnosed multiple myeloma (NDMM). Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been as
Autor:
Nigel H. Greig, Weiming Luo, Shaunna L. Beedie, Cindy H. Chau, Holly M. Rore, Shelby Barnett, William D. Figg, Neil Vargesson
Publikováno v:
Oncotarget
Thalidomide, a drug known for its teratogenic side-effects, is used successfully to treat a variety of clinical conditions including leprosy and multiple myeloma. Intense efforts are underway to synthesize and identify safer, clinically relevant anal
Autor:
Cindy H. Chau, Kirk R. Gustafson, Shaunna L. Beedie, Emily M Harris, Phoebe A. Huang, Christopher J. Schofield, William D. Figg, Melissa M. Cadelis, Brent R. Copp, Jonathan D. Strope, Goey Akl, Kristina M. Cook
Publikováno v:
Marine Drugs
Volume 16
Issue 7
Marine Drugs, Vol 16, Iss 7, p 241 (2018)
Volume 16
Issue 7
Marine Drugs, Vol 16, Iss 7, p 241 (2018)
Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism
Autor:
Jonathan D. Strope, Shaunna L. Beedie, William D. Figg, Stefan Dosa, Michael Gütschow, Gregor Schnakenburg, Agnieszka Ambrozak, Christian Steinebach
Publikováno v:
ChemMedChem. 13(19)
The introduction of fluorine into bioactive molecules is a matter of importance in medicinal chemistry. In this study, representatives of various chemical entities of fluoroaromatic compounds were synthesized. Depending on the reaction conditions, ei
Autor:
Shaunna L. Beedie, Michael T. Scerba, Nigel H. Greig, Weiming Luo, William D. Figg, David Tweedie, Neil Vargesson
Publikováno v:
Bioorganicmedicinal chemistry. 26(8)
A library of 15 novel and heretofore uncharacterized adamantyl and noradamantyl phthalimidines was synthesized and evaluated for neuroprotective and anti-angiogenic properties. Phthalimidine treatment in LPS-challenged cells effected reductions in le