Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shaunak S. Adkar"'
Autor:
Sharika Bamezai, Yapei Zhang, Manisha Kumari, Mozhgan Lotfi, Tom Alsaigh, Lingfeng Luo, Gayatri Suresh Kumar, Fudi Wang, Jianqin Ye, Madhu Puri, Romila Manchanda, Sesha Paluri, Shaunak S. Adkar, Yoko Kojima, Alice Ingelsson, Caitlin F. Bell, Nicolas G. Lopez, Changhao Fu, Ryan B. Choi, Zach Miller, Leo Barrios, Susan Walsh, Ferhaan Ahmad, Lars Maegdefessel, Bryan Ronain Smith, Nicholas J. Leeper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal of cells by macrophages, has emerged as a translational target for atherosclerosis. Systemic blockade o
Externí odkaz:
https://doaj.org/article/ed48ff63aa9a4c0ea91f4e3d3668de0d
Autor:
Amanda Dicks, Chia-Lung Wu, Nancy Steward, Shaunak S. Adkar, Charles A. Gersbach, Farshid Guilak
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Background Articular cartilage shows little or no capacity for intrinsic repair, generating a critical need of regenerative therapies for joint injuries and diseases such as osteoarthritis. Human-induced pluripotent stem cells (hiPSCs) offer
Externí odkaz:
https://doaj.org/article/f36c5cf155da46bd94d57c44b06c5220
Autor:
Joshua B. Black, Sean R. McCutcheon, Shataakshi Dube, Alejandro Barrera, Tyler S. Klann, Grayson A. Rice, Shaunak S. Adkar, Scott H. Soderling, Timothy E. Reddy, Charles A. Gersbach
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108460- (2020)
Summary: Technologies to reprogram cell-type specification have revolutionized the fields of regenerative medicine and disease modeling. Currently, the selection of fate-determining factors for cell reprogramming applications is typically a laborious
Externí odkaz:
https://doaj.org/article/e5a854fcace44b25a18afb8d37a05c63
Autor:
Niek GC Bloks, Zainab Harissa, Shaunak S Adkar, Amanda R Dicks, Ghazaleh Hajmousa, Nancy Steward, Roman I. Koning, Aat Mulder, Berend B.R. de Koning, Margreet Kloppenburg, Rodrigo Coutinho de Almeida, Yolande FM Ramos, Farshid Guilak, Ingrid Meulenbelt
ObjectivesThe etiology of osteoarthritis revolves around the interplay between genetic predisposition and perturbing environmental cues, such as mechanical stress. The pericellular matrix, with its hallmark proteins collagen type VI and fibronectin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229071623d737b0145103a4763eeccfd
https://doi.org/10.1101/2022.12.19.520461
https://doi.org/10.1101/2022.12.19.520461
Publikováno v:
Journal of vascular surgery. Venous and lymphatic disorders. 10(4)
Incompetent perforator veins (IPVs) contribute to venous pathology and are surgically treated based on hemodynamic measurements, size, and the CEAP (Clinical, Etiological, Anatomical, and Pathophysiological) classification. The objective of the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db75bf4eb952025377ba0203e4a921a
https://pubmed.ncbi.nlm.nih.gov/35717034
https://pubmed.ncbi.nlm.nih.gov/35717034
Autor:
Vidit Bhandarkar, Jennifer B. Kwon, Eric A. Josephs, D. Dewran Kocak, Shaunak S. Adkar, Charles A. Gersbach
Publikováno v:
Nature biotechnology
CRISPR (clustered regularly interspaced short palindromic repeat) systems have been broadly adopted for basic science, biotechnology, and gene and cell therapy. In some cases, these bacterial nucleases have demonstrated off-target activity. This crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd96facacaf79e28df0935d2badb8078
https://doi.org/10.1038/s41587-019-0095-1
https://doi.org/10.1038/s41587-019-0095-1
Autor:
Xiangyu Gao, Jianqin Ye, Elsie Gyang Ross, Simon Koplev, Clint L. Miller, Johan L.M. Björkegren, Gerard Pasterkamp, Tom Alsaigh, Adam W. Turner, Lingfeng Luo, Ying Wang, Zhongde Ye, Shaunak S Adkar, Michal Mokry, Fudi Wang, Nicholas J. Leeper, Hua Gao, Maria Elishaev, Lars Maegdefessel
Publikováno v:
Cardiovasc Res
Aims De-differentiation and activation of pro-inflammatory pathways are key transitions vascular smooth muscle cells (SMCs) make during atherogenesis. Here, we explored the upstream regulators of this 'atherogenic transition'. Methods and results Gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fe1a3b34e4f90f8c45eca61b51be85
https://pubmed.ncbi.nlm.nih.gov/34849613
https://pubmed.ncbi.nlm.nih.gov/34849613
Autor:
Shaunak S. Adkar, Charles A. Gersbach, Chia-Lung Wu, Farshid Guilak, Amanda Dicks, Nancy Steward
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
BackgroundArticular cartilage shows little or no capacity for intrinsic repair, generating a critical need of regenerative therapies for joint injuries and diseases such as osteoarthritis. Human-induced pluripotent stem cells (hiPSCs) offer a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73adfaccceec5ba16d3d5cfe09d97ff6
https://doi.org/10.1186/s13287-020-01597-8
https://doi.org/10.1186/s13287-020-01597-8
Autor:
G. Hajmousa, Farshid Guilak, Shaunak S. Adkar, Yolande F M Ramos, Ingrid Meulenbelt, R.G. Timmermans, Amanda Dicks, N.G. Bloks
Publikováno v:
Osteoarthritis and Cartilage. 29:S123-S124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c6cbc71939b59451c5df1a84f37d58d
https://doi.org/10.1016/j.joca.2021.02.173
https://doi.org/10.1016/j.joca.2021.02.173
Autor:
Charles A. Gersbach, Shaunak S. Adkar, Jonathan M. Brunger, Farshid Guilak, Chia-Lung Wu, Vincent P. Willard
Publikováno v:
Trends in Molecular Medicine. 23:917-931
Arthritis represents a family of complex joint pathologies responsible for the majority of musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, are chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed363c28af290baea1d3601788e98721
https://doi.org/10.1016/j.molmed.2017.08.002
https://doi.org/10.1016/j.molmed.2017.08.002