Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shaunaci A. Stevens"'
Autor:
Shaunaci A. Stevens, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Omer Cavus, Efosa V. Omorogbe, Elisa A. Bradley, Michael D. Dennis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6461 (2024)
Activation of the transcription factor NF-κB in cardiomyocytes has been implicated in the development of cardiac function deficits caused by diabetes. NF-κB controls the expression of an array of pro-inflammatory cytokines and chemokines. We recent
Externí odkaz:
https://doaj.org/article/682e5cbbbffc4471bf32eec69458e41c
Autor:
Shaunaci A. Stevens, Maria K. Gonzalez Aguiar, Allyson L. Toro, Esma I. Yerlikaya, Siddharth Sunilkumar, Ashley M. VanCleave, Jessica Pfleger, Elisa A. Bradley, Scot R. Kimball, Michael D. Dennis
Publikováno v:
American journal of physiology. Endocrinology and metabolism.
Endoplasmic reticulum (ER) stress and inflammation are hallmarks of myocardial impairment. Here we investigated a role for the stress response protein REDD1 as a molecular link between ER stress and inflammation in cardiomyocytes. In mice fed a high-
Publikováno v:
Circulation Research. 131
Obesity and type 2 diabetes represent a surging public health crisis, impacting nearly half of American adults. Heart failure is a leading cause of mortality and morbidity in patients with diabetes and obesity. Much remains unknown regarding the mole
Autor:
Michael D. Dennis, Siddharth Sunilkumar, Shaunaci A. Stevens, Allyson L. Toro, Scot R. Kimball, Carson J. Purnell, Jaclyn E. Welles
Publikováno v:
Am J Physiol Endocrinol Metab
Increased expression of the peptide hormone retinol-binding protein 4 (RBP4) has been implicated in the development of insulin resistance, type 2 diabetes, and visual dysfunction. Prior investigations of the mechanisms that influence RBP4 synthesis h
Autor:
William P. Miller, Allyson L. Toro, Siddharth Sunilkumar, Shaunaci A. Stevens, Ashley M. VanCleave, David L. Williamson, Alistair J. Barber, Michael D. Dennis
Publikováno v:
Diabetes. 71(5)
Clinical studies support a role for the protein regulated in development and DNA damage response 1 (REDD1) in ischemic retinal complications. To better understand how REDD1 contributes to retinal pathology, we examined human single-cell sequencing da