Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Shauna H Yuan"'
Autor:
Avinash Singh, G. Dalton Smedley, Jamee-Grace Rose, Kristina Fredriksen, Ying Zhang, Ling Li, Shauna H. Yuan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract The use of genetic engineering to generate point mutations in induced pluripotent stem cells (iPSCs) is essential for studying a specific genetic effect in an isogenic background. We demonstrate that a combination of p53 inhibition and pro-s
Externí odkaz:
https://doaj.org/article/9019233cf1924cccaf41cd8916c6d9a9
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionAlzheimer’s Disease (AD) constitutes a major societal problem with devastating neuropsychiatric involvement in over 90% of those diagnosed. The large spectrum of AD neuropsychiatric symptoms leads to polypharmacological prescribing that
Externí odkaz:
https://doaj.org/article/94df63f53707493c9fde139224d98a83
Autor:
Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Charles Mosier, Janneca Ames, Charisse Winston, Christopher B. Lietz, Zhenze Jiang, Anthony J. O’Donoghue, Tsuneya Ikezu, Robert A. Rissman, Shauna H. Yuan, Vivian Hook
Publikováno v:
ACS Omega, Vol 6, Iss 20, Pp 13033-13056 (2021)
Externí odkaz:
https://doaj.org/article/85df60e77971439a9aa48ddc16680670
Autor:
Yi Su, Shaney Flores, Guoqiao Wang, Russ C. Hornbeck, Benjamin Speidel, Nelly Joseph‐Mathurin, Andrei G. Vlassenko, Brian A. Gordon, Robert A. Koeppe, William E. Klunk, Clifford R. Jack Jr., Martin R. Farlow, Stephen Salloway, Barbara J. Snider, Sarah B. Berman, Erik D. Roberson, Jared Brosch, Ivonne Jimenez‐Velazques, Christopher H. vanDyck, Douglas Galasko, Shauna H. Yuan, Suman Jayadev, Lawrence S. Honig, Serge Gauthier, Ging‐Yuek R. Hsiung, Mario Masellis, William S. Brooks, Michael Fulham, Roger Clarnette, Colin L. Masters, David Wallon, Didier Hannequin, Bruno Dubois, Jeremie Pariente, Raquel Sanchez‐Valle, Catherine Mummery, John M. Ringman, Michel Bottlaender, Gregory Klein, Smiljana Milosavljevic‐Ristic, Eric McDade, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 180-190 (2019)
Abstract Introduction Quantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. Th
Externí odkaz:
https://doaj.org/article/6e1734993f954447b3409ef075057895
Autor:
Patrick Reilly, Charisse N. Winston, Kelsey R. Baron, Margarita Trejo, Edward M. Rockenstein, Johnny C. Akers, Najla Kfoury, Marc Diamond, Eliezer Masliah, Robert A. Rissman, Shauna H. Yuan
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 222-234 (2017)
Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (NFT)
Externí odkaz:
https://doaj.org/article/6a8083b02931438ba22fb5252d2c5236
Autor:
Michael S. Rafii, Olivier Sol, William C. Mobley, Saskia Delpretti, Brian G. Skotko, Anna D. Burke, Marwan N. Sabbagh, Shauna H. Yuan, Robert A. Rissman, Margaret Pulsifer, Casey Evans, A. Carol Evans, Gregory Beth, Nicolas Fournier, Julian A. Gray, Antonio Melo dos Santos, Valerie Hliva, Marija Vukicevic, Marie Kosco-Vilbois, Johannes Streffer, Andrea Pfeifer, Howard H. Feldman
Publikováno v:
JAMA Neurol
IMPORTANCE: Individuals with Down syndrome (DS) are at high risk of developing Alzheimer disease due to an increased dose of the amyloid precursor protein gene, APP, which leads to increased levels of full-length APP and its products, including amylo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd5f3695d138162823811f3cefe693f
https://pubmed.ncbi.nlm.nih.gov/35532913
https://pubmed.ncbi.nlm.nih.gov/35532913
Autor:
Shauna H. Yuan, Sonya G. Wang
Publikováno v:
Case Reports in Neurological Medicine, Vol 2018 (2018)
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by head trauma. Diagnosis of this disease is difficult as reliable biomarkers have not been established and often this clinical entity is underappreciated with poor recognit
Externí odkaz:
https://doaj.org/article/79c1e761b52f4f2b9d89b569cd159765
Autor:
Shauna H. Yuan, Sonya G. Wang
Publikováno v:
Case Reports in Neurological Medicine, Vol 2018 (2018)
Chronic traumatic encephalopathy (CTE) has been receiving increasing attention due to press coverage of professional football players. The devastating sequelae of CTE compel us to aim for early diagnosis and treatment. However, by current standards,
Externí odkaz:
https://doaj.org/article/d0a0358983e34687b36955e69ccf44c5
Autor:
Charisse N. Winston, Janneca Ames, Zhenze Jiang, Qing Liu, Shauna H. Yuan, Anthony J. O’Donoghue, Christopher B. Lietz, Tsuneya Ikezu, Charles Mosier, Vivian Hook, Sonia Podvin, Brent Aulston, Alexander Jones, Robert A. Rissman
Publikováno v:
ACS Omega, Vol 6, Iss 20, Pp 13033-13056 (2021)
ACS Omega
ACS Omega
The accumulation and propagation of hyperphosphorylated tau (p-Tau) is a neuropathological hallmark occurring with neurodegeneration of Alzheimer’s disease (AD). Extracellular vesicles, exosomes, have been shown to initiate tau propagation in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c08dc74042520a07c698d65777ad5d
https://doaj.org/article/85df60e77971439a9aa48ddc16680670
https://doaj.org/article/85df60e77971439a9aa48ddc16680670
Autor:
Grace Woodruff, Jessica E. Young, Fernando J. Martinez, Floyd Buen, Athurva Gore, Jennifer Kinaga, Zhe Li, Shauna H. Yuan, Kun Zhang, Lawrence S.B. Goldstein
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 974-985 (2013)
Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most co
Externí odkaz:
https://doaj.org/article/b6163cb80f724d8a9252a7d182cc3f52