Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shauna West"'
Autor:
Gareth C. G. Davies, Neesha Dedi, Paul S. Jones, Lara Kevorkian, David McMillan, Cristina Ottone, Monika-Sarah E. D. Schulze, Anthony Scott-Tucker, Roohi Tewari, Shauna West, Michael Wright, Tania F. Rowley
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTGremlin-1, a high-affinity antagonist of bone morphogenetic proteins (BMP)-2, −4, and −7, is implicated in tumor initiation and progression. Increased gremlin-1 expression, and therefore suppressed BMP signaling, correlates with poor prog
Externí odkaz:
https://doaj.org/article/b953f7c54c694fe2b318ac8406c9743d
Autor:
Ralph Adams, Asher Maroof, Terry Baker, Alastair D. G. Lawson, Ruth Oliver, Ross Paveley, Steve Rapecki, Stevan Shaw, Pavan Vajjah, Shauna West, Meryn Griffiths
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F, have been shown to be functionally dysregulated in certain human
Externí odkaz:
https://doaj.org/article/b1dbe735c4a147d884a03b1106dffb94
Autor:
Alastair D. G. Lawson, Shauna West, Richard Lamb, James T. Heads, Ruodan Nan, Ralph Adams, Peter Charles Elliott, Alison Turner, Sebastian Kelm, Kerry Louise Tyson, Sarfaraj Topia
Publikováno v:
Protein Engineering, Design and Selection
Native state aggregation is an important concern in the development of therapeutic antibodies. Enhanced knowledge of mAb native state aggregation mechanisms would permit sequence-based selection and design of therapeutic mAbs with improved developabi
Autor:
Terry Baker, Stevan Shaw, Meryn Griffiths, Steve Rapecki, Alastair D. G. Lawson, Ralph Adams, Shauna West, Ruth Oliver, Ross A. Paveley, Pavan Vajjah, Asher Maroof
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F, have been shown to be functionally dysregulated in certain human
Autor:
Paul Atherfold, Hanna Hailu, Louis Christodoulou, Lena E. D’Hooghe, Bryan Smith, Helene Margaret Finney, Frank R. Brennan, Stevan Shaw, Kerry Louise Tyson, Daniel John Lightwood, Andrea Kiessling, Kevin Greenslade, Omar Qureshi, Lara Kevorkian, Rebecca Munro, Kate L. Dixon, Rocio Lledo-Garcia, Shauna West, Christoph Meier, Matthew C. Catley, Kaushik Sarkar, Alison Turner, Roohi Tewari, Sophie P. Shaw
Publikováno v:
mAbs
Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce pathogenic IgG in autoimmune and alloimmune diseases. We document the antibody isolation and compare
Autor:
Mark Jairaj, Emma Dave, Ralph Adams, Shauna West, Laura Griffin, Oliver Zaccheo, Sam Philip Heywood, David Paul Humphreys, Tom Ceska, Joanne E. Compson, Alastair Dg. Lawson, Terry Baker
Publikováno v:
mAbs
We generated an anti-albumin antibody, CA645, to link its Fv domain to an antigen-binding fragment (Fab), thereby extending the serum half-life of the Fab. CA645 was demonstrated to bind human, cynomolgus, and mouse serum albumin with similar affinit
Autor:
Kosei Eguchi, Hanna Hailu, Helen Neale, Geofrey Odede, Alexandra Lee, Amir Tirosh, Ediz S. Calay, Gabriel Birrane, Louise Howells, Carl Brendan Doyle, Shauna West, Adrian Moore, Ariel White, Karen Inouye, Gökhan S. Hotamisligil, Daniel John Lightwood, Rachel Garlish, Gurol Tuncman, Motohiro Sekiya, M. Furkan Burak
Publikováno v:
Science Translational Medicine. 7
The lipid chaperone aP2/FABP4 has been implicated in the pathology of many immunometabolic diseases, including diabetes in humans, but aP2 has not yet been targeted for therapeutic applications. aP2 is not only an intracellular protein but also an ac
Autor:
Sam Heywood, Dee Athwal, Bruce Carrington, Andrew George Popplewell, Andrew Nesbitt, Alastair David Griffiths Lawson, Amanda J. Suitters, and Alison Eddelston, P. Antoniw, Shauna West, Bryan Smith, Andrew Paul Chapman
Publikováno v:
Bioconjugate Chemistry. 12:750-756
Antibody fragments can be expressed at a high level in microbial systems, but they may have limited therapeutic value because they are rapidly eliminated from the body. We demonstrate here that site-specific conjugation or binding of bacterially deri
Autor:
Mukesh Sehdev, Andrew Paul Chapman, Paul Edward Stephens, Matthew W. Redden, Lloyd M. King, David P. Humphreys, Shauna West, Glover David John, Bryan J. Smith
Publikováno v:
Protein Engineering, Design and Selection. 13:201-206
The peptide sequence (N)DKTH(C) was previously investigated as a site for efficient, specific cleavage of a fusion protein by cupric ions using a humanized gamma1 Fab' as a model protein. Here we show that conservative mutations to three of the resid
Autor:
Alistair James Henry, Shauna West, David P. Humphreys, Shirley Jane Peters, C. Mark Smales, Paul Edward Stephens
Publikováno v:
The Journal of biological chemistry. 287(29)
The integrity of antibody structure, stability, and biophysical characterization are becoming increasingly important as antibodies receive increasing scrutiny from regulatory authorities. We altered the disulfide bond arrangement of an IgG4 molecule