Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shaun W Carlson"'
Autor:
Sarah E. Svirsky, Jeremy Henchir, Madison Parry, Erik Holets, Ting Zhang, George K. Gittes, Shaun W. Carlson, C. Edward Dixon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding protein, result in significant impairment across various hippocampal-dependent learning and memory tasks. Conversely, increasing levels of Ng facilitates synaptic plastic
Externí odkaz:
https://doaj.org/article/af035727d13b423294d6fc156cba879f
Autor:
Sindhu K Madathil, Shaun W Carlson, Jennifer M Brelsfoard, Ping Ye, A Joseph D'Ercole, Kathryn E Saatman
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67204 (2013)
Traumatic brain injury (TBI) survivors often suffer from long-lasting cognitive impairment that stems from hippocampal injury. Systemic administration of insulin-like growth factor-1 (IGF-1), a polypeptide growth factor known to play vital roles in n
Externí odkaz:
https://doaj.org/article/16c4ad97a8ec40e996f44a89645d510f
Autor:
Sarah E. Svirsky, Youming Li, Jeremy Henchir, Anna Rodina, Shaun W. Carlson, Gabriela Chiosis, C. Edward Dixon
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106331- (2023)
Under normal conditions, heat shock proteins work in unison through dynamic protein interactions collectively referred to as the “chaperome.” Recent work revealed that during cellular stress, the functional interactions of the chaperome are modif
Externí odkaz:
https://doaj.org/article/6d24c9ac2c494c03aaf12b6a97227875
Autor:
Ricky Whitener, Jeremy J. Henchir, Thomas A. Miller, Emily Levy, Aubrienne Krysiewicz-Bell, Eliza S. LaRovere Abrams, Shaun W. Carlson, Naresh Menon, C. Edward Dixon, Michael J. Whalen, Claude J. Rogers
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 158-167 (2022)
Severe traumatic brain injury (TBI), such as that suffered by patients with cerebral contusion, is a major cause of death and disability in young persons. Effective therapeutics to treat or mitigate the effects of severe TBI are lacking, in part beca
Externí odkaz:
https://doaj.org/article/34d7cea5ed5541d494f13ceecb9da5a1
Autor:
Katherine M. Fronczak, Andrea Roberts, Sarah Svirsky, Madison Parry, Erik Holets, Jeremy Henchir, C. Edward Dixon, Shaun W. Carlson
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Repetitive mild traumatic brain injury (rmTBI) is a prominent public health concern, with linkage to debilitating chronic sequelae. Developing reliable and well-characterized preclinical models of rmTBI is imperative in the investigation of the under
Externí odkaz:
https://doaj.org/article/1f6ea21678784a44a20bd54a3b178dd0
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Insulin-like growth factor 1 (IGF-1) is known to have diverse effects on brain structure and function, including the promotion of stem cell proliferation and neurogenesis in the adult dentate gyrus. However, the intracellular pathways downst
Externí odkaz:
https://doaj.org/article/e2ae59a77df6443398e78c028a1d3e03
Autor:
Sarah E, Svirsky, Nicholas S, Ranellone, Madison, Parry, Erik, Holets, Jeremy, Henchir, Youming, Li, Shaun W, Carlson, C Edward, Dixon
Publikováno v:
Neuroscience. 499:130-141
Traumatic brain injury (TBI) is known to impair synaptic function, and subsequently contribute to observed cognitive deficits. Retinoic Acid (RA) signaling modulates expression of synaptic plasticity proteins and is involved in hippocampal learning a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4bd859b76971cbc49f493149d19eca
https://doi.org/10.1016/j.neuroscience.2022.07.021
https://doi.org/10.1016/j.neuroscience.2022.07.021
Autor:
Jeremy Henchir, Shaun W. Carlson, Benjamin E Zusman, Zachary S. Bailey, Vincent Vagni, Ruchira M. Jha, Keri Janesko-Feldman, Janice S. Gilsdorf, Patrick M. Kochanek, Deborah A. Shear, C. Edward Dixon
Publikováno v:
J Neurotrauma
Civilian traumatic brain injury (TBI) guidelines recommend resuscitation of patients with hypotensive TBI with crystalloids. Increasing evidence, however, suggests that whole blood (WB) resuscitation may improve physiological and survival outcomes at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6336df15e84e3629001ff01b7cb945a2
https://doi.org/10.1089/neu.2021.0157
https://doi.org/10.1089/neu.2021.0157
Autor:
Samuel M. Poloyac, Patrick M. Kochanek, Shaun W. Carlson, Milos D. Ikonomovic, Edwin K. Jackson, Ava M. Puccio, Amery Treble-Barna, Corina O. Bondi, Michael J. Bell, Alicia K. Au, Ruchira M. Jha, Hülya Bayır, D. Lansing Taylor, Dennis W. Simon, Yvette P. Conley, Jonathan Elmer, Valerian E. Kagan, Stephen R. Wisniewski, Lori Shutter, Philip E. Empey, Robert S. B. Clark, Anthony E. Kline, Amy K. Wagner, Christopher M. Horvat, Travis C. Jackson, Steven H. Graham, C. Edward Dixon, Andrew M. Stern, David O. Okonkwo
Publikováno v:
J Neurotrauma
New neuroprotective therapies for severe traumatic brain injury (TBI) have not translated from pre-clinical to clinical success. Numerous explanations have been suggested in both the pre-clinical and clinical arenas. Coverage of TBI in the lay press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd3b52854514273c852375f13bf9cdd
https://doi.org/10.1089/neu.2018.6203
https://doi.org/10.1089/neu.2018.6203
Publikováno v:
J Neurotrauma
Traumatic brain injury (TBI) is known to cause short- and long-term synaptic changes in the brain, possibly underlying downstream cognitive impairments. Neuronal levels of neurogranin, a calcium-sensitive calmodulin-binding protein essential for syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd06b6786a08711162b8f1b3595e3f6d
https://doi.org/10.1089/neu.2019.6759
https://doi.org/10.1089/neu.2019.6759