Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Shaun W, Lee"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/d01c10e139f549ca98c0c16f501f68c6
Autor:
Hannah N. Corman, Jessica N. Ross, Francisco R. Fields, Douglas A. Shoue, Mary Ann McDowell, Shaun W. Lee
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the protozoan parasite Leishmania species with a wide range of clinical manifestations. Current treatment options can be highly toxic and expensive, wit
Externí odkaz:
https://doaj.org/article/e52fda037f4e4363ac5869abaea5de5d
Autor:
Daniel E. Hammers, Deborah L. Donahue, Zachary D. Tucker, Brandon L. Ashfeld, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive human pathogen that employs several secreted and surface-bound virulence factors to manipulate its environment, allowing it to cause a variety of disease outcomes. One such virule
Externí odkaz:
https://doaj.org/article/397b7e5730124dff91f61b76073941ea
Autor:
Yetunde A. Ayinuola, Sheiny Tjia-Fleck, Bradley M. Readnour, Zhong Liang, Olawole Ayinuola, Lake N. Paul, Shaun W. Lee, Vincent A. Fischetti, Victoria A. Ploplis, Francis J. Castellino
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The proteolytic activity of human plasmin (hPm) is utilized by various cells to provide a surface protease that increases the potential of cells to migrate and disseminate. Skin-trophic Pattern D strains of Streptococcus pyogenes (GAS), e.g., GAS iso
Externí odkaz:
https://doaj.org/article/4262c9215512430a994f4458ce0b40ed
Autor:
Olawole Ayinuola, Yetunde A. Ayinuola, Cunjia Qiu, Shaun W. Lee, Victoria A. Ploplis, Francis J. Castellino
Publikováno v:
MicrobiologyOpen, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract The direct binding of human plasminogen (hPg), via its kringle‐2 domain (K2hPg), to streptococcal M‐protein (PAM), largely contributes to the pathogenesis of Pattern D Group A Streptococcus pyogenes (GAS). However, the mechanism of compl
Externí odkaz:
https://doaj.org/article/78546729315540d782ae9f06dfef47b7
Autor:
Jeanne Romero-Severson, Thomas E. Moran, Donna G. Shrader, Francisco R. Fields, Susan Pandey-Joshi, Clayton L. Thomas, Emily C. Palmer, Joshua D. Shrout, Michael E. Pfrender, Shaun W. Lee
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Bacteriocins are a highly diverse group of antimicrobial peptides that have been identified in a wide range of commensal and probiotic organisms, especially those resident in host microbiomes. Rising antibiotic resistance have fueled renewed research
Externí odkaz:
https://doaj.org/article/2b229bf929bb4fe1b433419c70181d68
Autor:
Henry M. Vu, Daniel E. Hammers, Zhong Liang, Gabrielle L. Nguyen, Mary E. Benz, Thomas E. Moran, Dustin L. Higashi, Claudia J. Park, Yetunde A. Ayinuola, Deborah L. Donahue, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Invasive outcomes of Group A Streptococcus (GAS) infections that involve damage to skin and other tissues are initiated when these bacteria colonize and disseminate via an open wound to gain access to blood and deeper tissues. Two critical GAS virule
Externí odkaz:
https://doaj.org/article/cedcfe7385ce465e9a17ac5cc038221c
Autor:
Samantha M. Golomb, Ian H. Guldner, Anqi Zhao, Qingfei Wang, Bhavana Palakurthi, Emilija A. Aleksandrovic, Jacqueline A. Lopez, Shaun W. Lee, Kai Yang, Siyuan Zhang
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108438- (2020)
Summary: Phenotypic and functional plasticity of brain immune cells contribute to brain tissue homeostasis and disease. Immune cell plasticity is profoundly influenced by tissue microenvironment cues and systemic factors. Aging and gut microbiota dys
Externí odkaz:
https://doaj.org/article/625c5863cd5043339765b3fa37ba8693
Autor:
Jessica N. Ross, Francisco R. Fields, Veronica R. Kalwajtys, Alejandro J. Gonzalez, Samantha O’Connor, Angela Zhang, Thomas E. Moran, Daniel E. Hammers, Katelyn E. Carothers, Shaun W. Lee
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The circularized bacteriocin enterocin AS-48 produced by Enterococcus sp. exhibits antibacterial activity through membrane disruption. The membrane-penetrating activity of enterocin AS-48 has been attributed to a specific alpha-helical region on the
Externí odkaz:
https://doaj.org/article/1ef6a42d59ca4075bca590f5425f6a34
Autor:
Francisco R Fields, Niraja Suresh, Morgan Hiller, Stefan D Freed, Kasturi Haldar, Shaun W Lee
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0234100 (2020)
Von Hippel-Lindau disease (VHL) is an autosomal dominant rare disease that causes the formation of angiogenic tumors. When functional, pVHL acts as an E3 ubiquitin ligase that negatively regulates hypoxia inducible factor (HIF). Genetic mutations tha
Externí odkaz:
https://doaj.org/article/6952bb715e1b42b7baf6be868c1fe731