Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shaun Stewart"'
Autor:
Andre A. R. Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura P. Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca A. Buonpane, Horacio G. Nastri, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted com
Externí odkaz:
https://doaj.org/article/33ec78a25c5c442aa8059bd64ee24afc
Autor:
Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Jing Zhou, Arpita Mondal, Yao-bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda J. A. Hendriks, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Wilfred Marissen, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Soyeon Kim, Marina Martinez, Shaun O’Brien, Edmund Moon, Steven Albelda, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Alexander B. H. Bakker, Peggy Scherle, Ton Logtenberg, Gregory Hollis, John de Kruif, Reid Huber, Patrick A. Mayes, Mark Throsby
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific ant
Externí odkaz:
https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30
Autor:
Jing Zhou, Mark Throsby, Lex Bakker, Arpita Mondal, Wilfred Marissen, Paul Tacken, Steef Engels, Liang-Chuan Wang, Patrick Mayes, Cecile Geuijen, Rinse Klooster, Pieter Fokko Van Loo, Yao-Bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda Hendriks, Hans van der Maaden, Eric Rovers, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Ton Logtenberg, Simon Plyte
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/3ac9962628b4422ba42992da2d11038e
Autor:
Shaun Stewart, Floris Fransen, Shane Harvey, Franziska Mortensen, Anita Stam, Rahel Awdew, Arpita Mondal, Christina Stevens, Eric Rovers, Steef Engels, Melissa Rentrop-Boeijen, Linda Hendriks, Brenda van Dieren, Rebecca Buonpane, Therese Visser, Pepijn Schellen, Ashwini Kulkarni, Jonathan Rios-Doria, Jing Zhou, Paul Tacken, Lu Lu, Vanessa Zondag-van der Zande, Cheng-Yen Huang, Renate den Blanken-Smit, John de Kruif, Rinse Klooster, Simon Plyte, Horacio Nastri, Patrick Mayes
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Andrew Gabell, Timothy Crain, Glenn D Hines, Farzin Amzajerdian, Bruce W Barnes, David Becker, Helen Tuckett, Jack McCubbine, Shaun Stewart, Geoff Wells, Wayne Hewison, Andrew McGrath, Will Featherstone, Mathew Tubb, Scott Moore, Jamin Greenbaum
Airborne gravimetry relies on removing inertial aircraft accelerations from total accelerations measured by an onboard gravimeter. NASA developed a Navigation Doppler Lidar ('NDL') for the US Space Program. The NDL measures velocities at the 1 mm/sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8e2cf5572f857a06a1d162e12e3633
Autor:
Steven M. Albelda, Steef Engels, Soyeon Kim, Alla Volgina, Floris Fransen, Linda Johanna Aleida Hendriks, Cecile Geuijen, Shane Harvey, Horacio Nastri, Reid Huber, Leslie Hall, Gregory Hollis, John de Kruif, Jing Zhou, Abdul Basmeleh, Pieter Fokko Van Loo, Mark Throsby, Edmund K. Moon, Arjen Kramer, Willem Bartelink, Eric Rovers, Paul Tacken, Hans van der Maaden, Vanessa Zondag-van der Zande, Cheng Yen Huang, Rinse Klooster, Liang Chuan Wang, Ashwini Kulkarni, Chrysi Kanellopoulou, Marina Martinez, Wilfred E. Marissen, Shaun O'Brien, Alexander Berthold Hendrik Bakker, Ton Logtenberg, Renate den Blanken-Smit, Shaun Stewart, Peggy Scherle, Arpita Mondal, Patrick Mayes, Yao bin Liu, Thomas Condamine
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Immune checkpoint inhibitors demonstrate clinical activity in many tumor types, however, only a fraction of patients benefit. Combining CD137 agonists with these inhibitors increases anti-tumor activity preclinically, but attempts to translate these
Autor:
Cecile Geuijen, Floris Fransen, Renate den Blanken-Smit, Ton Logtenberg, Vanessa Zondag-van der Zande, Thomas Condamine, Arjen Kramer, Willem Bartelink, Mark Throsby, Pieter Fokko Van Loo, Liang-Chuan Wang, Yao-Bin Liu, Ashwini Kulkarni, Chrysi Kanellopoulou, Rinse Klooster, Simon Plyte, Wilfred E. Marissen, Linda Johanna Aleida Hendriks, Arpita Mondal, Abdul Basmeleh, Shane Harvey, Lex Bakker, Leslie Hall, Jing Zhou, Paul Tacken, Eric Rovers, Hans van der Maaden, Steef Engels, Shaun Stewart, Patrick Mayes, Cheng-Yen Huang, Alla Volgina, Horacio Nastri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background MCLA-145 is a CD137 x PD-L1 bispecific antibody that releases PD-L1 mediated T-cell inhibition and activates and expands T cells through agonism of CD137. Immune checkpoint inhibitors (ICI) against PD-(L)1 have demonstrated anti-tumor effi
Autor:
Enrique Zarate Losoya, Samuel F. Noynaert, Jimmy Hicks, Zenon Medina-Zetina, Eduardo Gildin, Shaun Stewart, Tim Crain
Publikováno v:
Day 4 Thu, July 30, 2020.
Simulation of drilling processes involves the seamless integration of strongly coupled physics, numeric, and economic models. Operators desire advanced drilling simulation software that can mimic reality and yet be practical for daily operations. At
Autor:
Abdul Basmeleh, Cecile Geuijen, Patrick Mayes, Paul Tacken, Linda Kaldenberg-Hendriks, Willem Bartelink, Gregory Hollis, Jing Zhou, Cheng-Yen Huang, John de Kruif, Rinse Klooster, Steve Wang, Arjen Kramer, Reid Huber, Mark Throsby, Renate den Blanken-Smit, Shaun Stewart, Horacio Nastri, Vanessa Zondag-van de Zande
Publikováno v:
Cancer Research. 79:541-541
CD137 (4-1BB) is a transmembrane costimulatory receptor on T and NK cells that enhances adaptive immune responses and is a critical mediator of antitumor immunity. CD137 signaling requires receptor clustering normally facilitated by the trimeric CD13
Autor:
Joel A. Kooren, Pratik D. Jagtap, James E. Johnson, Alan Blakely, Kevin Murray, Joel D. Rudney, Nelson L. Rhodus, Shaun Stewart, Timothy J. Griffin
Publikováno v:
Proteomics. 15(20)
Metaproteomics characterizes proteins expressed by microorganism communities (microbiome) present in environmental samples or a host organism (e.g. human), revealing insights into the molecular functions conferred by these communities. Compared to co