Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation.

Autor: Shyamasree De Majumdar, Jing Yu, Maria Fookes, Sean P McAteer, Enrique Llobet, Sarah Finn, Shaun Spence, Avril Monahan, Avril Monaghan, Adrien Kissenpfennig, Rebecca J Ingram, José Bengoechea, David L Gally, Séamus Fanning, Joseph S Elborn, Thamarai Schneiders

Publikováno v: PLoS Pathogens, Vol 11, Iss 1, p e1004627 (2015)

Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, litt

Externí odkaz: https://doaj.org/article/d280d78a40a04c13b06cf48c876f1155

The Immunophilin Protein FKBPL and its Peptide Derivatives are Novel Regulators of Vascular Integrity and Inflammation via Nf-κB Signaling

Autor: Adrien Kissenpfennig, Irina G. Tikhonova, Shaun Spence, Clive Drakeford, Amy Short, Stephanie Annett, Pauline Johnson, Ciaran Campbell, Carolina Denis Garciarena, Danny Sharpe, Jennifer Dowling, Margaret Dennehy, Anita Yakkundi, Steve Kerrigan, Gianpiero L. Cavalleri, Fiona Furlong, Jacqueline C.Y. Lai, Tracy Robson, James O'Donnell, Gillian Moore

Publikováno v: SSRN Electronic Journal.

A breakdown in vascular integrity and excessive inflammation are hallmarks of serious pathological conditions including sepsis, acute respiratory distress syndrome (ARDs) and most recently, severe COVID-19. FK506 – binding protein like (FKBPL) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e957afae6fcc54722564da8ff0ed54
https://doi.org/10.2139/ssrn.3858052

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization

Autor: Shaun Spence, James F. Burrows, James A. Johnston, Helen O. McCarthy, Roberta E. Burden, Brian Walker, Donna M. Small, Shauna Hegarty, Christopher J. Scott, Adrien Kissenpfennig, Jakub Jaworski, Cheryl McFarlane

Publikováno v: International Journal of Cancer. 133:2102-2112

Recent murine studies have demonstrated that tumor-associated macrophages in the tumor microenvironment are a key source of the pro-tumorigenic cysteine protease, cathepsin S. We now show in a syngeneic colorectal carcinoma murine model that both tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8477404e5a5246a189db53b0b9d106b5
https://doi.org/10.1002/ijc.28238

Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

Autor: Thamarai Schneiders, Sarah Finn Shaun Spence, Rebecca J. Ingram, Maria Fookes, Avril Monaghan, Sean P. McAteer, Jing Yu, José A. Bengoechea, Enrique Llobet, David L. Gally, Séamus Fanning, Shyamasree De Majumdar, Joseph Elborn, Adrien Kissenpfennig

Publikováno v: De Majumdar, S, Yu, J, Fookes, M, Mcateer, S P, Llobet, E, Spence, S F S, Monaghan, A, Kissenpfennig, A, Ingram, R J, Bengoechea, J, Gally, D L, Fanning, S, Elborn, J S & Schneiders, T 2016, ' Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation ', PLoS Pathogens, vol. 12, no. 5, e1005649 . https://doi.org/10.1371/journal.ppat.1005649
PLoS Pathogens, Vol 12, Iss 5, p e1005649 (2016)
De Majumdar, S, Yu, J, Fookes, M, McAteer, S P, Llobet, E, Spence, S F S, Monaghan, A, Kissenpfennig, A, Ingram, R J, Bengoechea, J, Gally, D L, Fanning, S, Elborn, J S & Schneiders, T 2016, ' Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation ', PLoS Pathogens, vol. 12, no. 5, pp. e1005649 . https://doi.org/10.1371/journal.ppat.1005649

The authors would like to correct Fig 4 and Fig 7, as errors were made in the preparation of these figures for publication. In Fig 4B, the existing panels for the gene promoters yrbF and ybhT are the wrong EMSA images for these promoters. The authors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cfdb65662d3b52bbfa2913ef261ad3
https://www.pure.ed.ac.uk/ws/files/25302788/journal.ppat.1005649.PDF

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

Autor: Shaun Spence, James F. Burrows, James A. Johnston, Peter Smyth, Michelle K. Greene, Efrosyni Themistou, Jonathan Beck, Daniela Schmid, Umar Hamid, Sharif Abdelghany, Adrien Kissenpfennig, Sean P. Saunders, Daniel F. McAuley, Baljinder K. Bains, Cecilia O'Kane, Denise C. Fitzgerald, Francois Fay, Emily Hams, Marianne Fitzgerald, Donna M. Small, Padraic G. Fallon, Christopher J. Scott

Publikováno v: Spence, S, Greene, M K, Fay, F, Hams, E, Saunders, S P, Hamid, U, Fitzgerald, M, Beck, J, Bains, B K, Smyth, P, Themistou, E, Small, D M, Schmid, D, O'Kane, C M, Fitzgerald, D C, Abdelghany, S M, Johnston, J A, Fallon, P G, Burrows, J F, McAuley, D F, Kissenpfennig, A & Scott, C J 2015, ' Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation ', Science Translational Medicine, vol. 7, no. 303, 140 . https://doi.org/10.1126/scitranslmed.aab3459

Sepsis is the most frequent cause of death in hospitalized patients, and severe sepsis is a leading contributory factor to acute respiratory distress syndrome (ARDS). At present, there is no effective treatment for these conditions, and care is prima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245ba67044a52f03c8b240125ecf0aa7
https://doi.org/10.1126/scitranslmed.aab3459