Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Shaun S. Sanders"'
Autor:
Charlotte A. Townsend, Andrey A. Petropavlovskiy, Jordan A. Kogut, Alysha M. Church, Shaun S. Sanders
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103068- (2024)
Summary: S-acylation, commonly palmitoylation, is the addition of fatty acids to cysteines to regulate protein localization and function. S-acylation detection has been hampered by limited sensitivity and selectivity in low-protein, costly samples li
Externí odkaz:
https://doaj.org/article/3a308ca501bd42ad915b92d2a309317b
Autor:
Nicolas H. Piguel, Shaun S. Sanders, Francesca I. De Simone, Maria D. Martin-de-Saavedra, Emmarose McCoig, Leonardo E. Dionisio, Katharine R. Smith, Gareth M. Thomas, Peter Penzes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an
Externí odkaz:
https://doaj.org/article/52a343df27d8423883a4ff7c95f0ced1
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is subjected to
Externí odkaz:
https://doaj.org/article/2dceb005525940f3bd67949a75fac1f7
Autor:
Fanny L. Lemarié, Nicholas S. Caron, Shaun S. Sanders, Mandi E. Schmidt, Yen T.N. Nguyen, Seunghyun Ko, Xiaohong Xu, Mahmoud A. Pouladi, Dale D.O. Martin, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105479- (2021)
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. HTT is subject to multiple post-translational modifications (PTMs) that
Externí odkaz:
https://doaj.org/article/2444a423afaf47e1a97c55c90c9868f3
Autor:
Jingwen Niu, Shaun S. Sanders, Hey-Kyeong Jeong, Sabrina M. Holland, Yue Sun, Kaitlin M. Collura, Luiselys M. Hernandez, Haoliang Huang, Michael R. Hayden, George M. Smith, Yang Hu, Yishi Jin, Gareth M. Thomas
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108365- (2020)
Summary: After optic nerve crush (ONC), the cell bodies and distal axons of most retinal ganglion cells (RGCs) degenerate. RGC somal and distal axon degenerations were previously thought to be controlled by two parallel pathways, involving activation
Externí odkaz:
https://doaj.org/article/465db966de9646949ceb4c790e1a07a5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) controls growth and proliferation of non-neuronal cells, while during neuronal development mTORC1 responds to glutamate and neurotrophins to promote neuronal migration and dendritic arbori
Externí odkaz:
https://doaj.org/article/c1d7c744e91149d6beac6b8bd178ce79
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 11 (2019)
N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival. Studies have shown enhanced extrasynaptic GluN2B-type NMDAR (2B-NMDAR) activity
Externí odkaz:
https://doaj.org/article/cbe10b457f9940f483f0fc2f41fbb3cb
Autor:
Kun Huang, Martin H. Kang, Caitlin Askew, Rujun Kang, Shaun S. Sanders, Junmei Wan, Nicholas G. Davis, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 207-215 (2010)
Excitotoxicity plays a key role in the selective vulnerability of striatal neurons in Huntington disease (HD). Decreased glutamate uptake by glial cells could account for the excess glutamate at the synapse in patients as well as animal models of HD.
Externí odkaz:
https://doaj.org/article/21b80b144a794312a9e9d7669763884c
Autor:
Shaun S Sanders, Luiselys M Hernandez, Heun Soh, Santi Karnam, Randall S Walikonis, Anastasios V Tzingounis, Gareth M Thomas
Publikováno v:
eLife, Vol 9 (2020)
The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However, ZDHHC14’s neuronal roles are unknown. Here, we identify the PDZ domain-containi
Externí odkaz:
https://doaj.org/article/3bf2d48f0eda4e9999d27548f27e9678
Autor:
Audrey Montersino, Kaitlin M. Collura, Shaun S. Sanders, Sabrina M. Holland, Jingwen Niu, Gareth M. Thomas
Publikováno v:
J Biol Chem
Palmitoylation, the modification of proteins with the lipid palmitate, is a key regulator of protein targeting and trafficking. However, knowledge of the roles of specific palmitoyl acyltransferases (PATs), which catalyze palmitoylation, is incomplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0651094836fa5ec194d41c9b2a1c53c
https://doi.org/10.1074/jbc.ra120.013815
https://doi.org/10.1074/jbc.ra120.013815