Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shaun S. Kumar"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
We have identified distinct histamine pharmacodynamic response phenotypes in children with allergic disease utilizing histamine iontophoresis with laser Doppler (HILD). These response phenotypes may be relevant in guiding therapeutic decision making
Externí odkaz:
https://doaj.org/article/c378e99208d24ba1afc62f32f9fbc4ae
Autor:
Robert M. Ward, Elena Y. Enioutina, Tsuyoshi Fukuda, Joseph R. Sherbotie, Sílvia M. Illamola, Jessica K. Roberts, Shaun S. Kumar, Jahidur Rashid, Catherine M.T. Sherwin, Kathleen M. Job
Publikováno v:
Expert opinion on drug metabolismtoxicology. 17(7)
Introduction: Graft survival in pediatric kidney transplant patients has increased significantly within the last three decades, correlating with the discovery and utilization of new immunosuppressants as well as improvements in patient care. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f68c2f2babdf4cb08c3b4d6fce84b9
https://pubmed.ncbi.nlm.nih.gov/34121566
https://pubmed.ncbi.nlm.nih.gov/34121566
Autor:
Lynne Yao, Yaning Wang, Catherine M.T. Sherwin, Robert M. Ward, Jian Wang, Gerri Baer, Shaun S. Kumar, Gilbert J. Burckart
Publikováno v:
Clinical Pharmacology & Therapeutics. 105:1462-1470
The objective of this study was to evaluate the predictive performance of population models to predict renal clearance in newborns and infants. Pharmacokinetic (PK) data from eight drugs in 788 newborns and infants were used to evaluate the predictiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73f1f0b5b12f1ca2b1dbac659b9a76f
https://doi.org/10.1002/cpt.1332
https://doi.org/10.1002/cpt.1332
Autor:
Shaun S. Kumar, Candice D. Fike, Catherine M.T. Sherwin, Kathleen M. Job, Jahidur Rashid, Xiaoxi Liu
Publikováno v:
Paediatr Drugs
Supplemental arginine has shown promise as a safe therapeutic option to improve endogenous nitric oxide (NO) regulation in cardiovascular diseases associated with endothelial dysfunction. L-arginine, an endogenous amino acid, was reported in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73295c1c888e476facd239f9c1d3fd16
https://pubmed.ncbi.nlm.nih.gov/32140997
https://pubmed.ncbi.nlm.nih.gov/32140997
Autor:
Shaun S. Kumar, Xiaoxi Liu, Roger Gaedigk, Catherine M.T. Sherwin, Matthew W. Linakis, Diana G. Wilkins, John N. van den Anker, Andrea Gaedigk, Sarah F. Cook
Publikováno v:
Clinical Pharmacokinetics. 57:1325-1336
INTRODUCTION: Acetaminophen (paracetamol, APAP) is widely used as an analgesic and antipyretic drug in children and neonates. A number of enzymes contribute to the metabolism of acetaminophen, and genetic factors might be important to explain variabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9acf7057e6bf58aa11b0bd47bc3ea9
https://doi.org/10.1007/s40262-018-0634-9
https://doi.org/10.1007/s40262-018-0634-9
Autor:
Kenneth M. Williams, Carl M. J. Kirkpatrick, Hiddo J.L. Heerspink, M. Y. A. M. Kroonen, Garry G. Graham, Janna K. Duong, Richard O. Day, Shaun S. Kumar
Publikováno v:
European Journal of Clinical Pharmacology, 73(8), 981-990. Springer Verlag
The aims of this study were to investigate the relationship between metformin exposure, renal clearance (CLR), and apparent non-renal clearance of metformin (CLNR/F) in patients with varying degrees of kidney function and to develop dosing recommenda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b78bc425975155dab6df90ecb673822
https://doi.org/10.1007/s00228-017-2251-1
https://doi.org/10.1007/s00228-017-2251-1
Autor:
Shaun S. Kumar, Matthew W. Linakis, Diana G. Wilkins, John N. van den Anker, Catherine M.T. Sherwin, Andrea Gaedigk, Roger Gaedigk, Xiaoxi Liu
Publikováno v:
Clinical Pharmacology & Therapeutics. 101:S5-S99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc89bb00e69418727fb7535453ec342a
https://doi.org/10.1002/cpt.570
https://doi.org/10.1002/cpt.570
Autor:
Jerry R. Greenfield, Sophie L. Stocker, Kenneth M. Williams, Garry G. Graham, Felicity C. Smith, Shaun S. Kumar, Hannah E. Braithwaite, Richard O. Day, Jane E. Carland, Tim S. Cheng, Zhixin Liu, Mark Danta
Publikováno v:
Alimentary pharmacologytherapeuticsREFERENCES. 51(5)
BACKGROUND The FDA approved 'label' for metformin lists hepatic insufficiency as a risk for lactic acidosis. Little evidence supports this warning. AIMS To investigate the safety and pharmacokinetics of metformin in patients with chronic liver diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc192cbf63a73132c7d4a193d292b528
https://pubmed.ncbi.nlm.nih.gov/31960986
https://pubmed.ncbi.nlm.nih.gov/31960986
Autor:
Joseph E. Rower, Shaun S. Kumar, Xiaoxi Liu, Venkata K. Yellepeddi, Catherine M.T. Sherwin, Jahidur Rashid
Publikováno v:
Clinical pharmacokinetics. 58(1)
Physiologically based pharmacokinetic modeling and simulation is an important tool for predicting the pharmacokinetics, pharmacodynamics, and safety of drugs in pediatrics. Physiologically based pharmacokinetic modeling is applied in pediatric drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939634c9788e3e5e6204e40924057d06
https://pubmed.ncbi.nlm.nih.gov/29777528
https://pubmed.ncbi.nlm.nih.gov/29777528
Publikováno v:
British journal of clinical pharmacology. 84(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d99e50152abac9d0d9a5f58ad9eb3b
https://pubmed.ncbi.nlm.nih.gov/29637580
https://pubmed.ncbi.nlm.nih.gov/29637580