Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Shaun R Coughlin"'
Autor:
Jun Zou, Diana Tran, Mai Baalbaki, Ling Fung Tang, Annie Poon, Angelo Pelonero, Erron W Titus, Christiana Yuan, Chenxu Shi, Shruthi Patchava, Elizabeth Halper, Jasmine Garg, Irina Movsesyan, Chaoying Yin, Roland Wu, Lisa D Wilsbacher, Jiandong Liu, Ronald L Hager, Shaun R Coughlin, Martin Jinek, Clive R Pullinger, John P Kane, Daniel O Hart, Pui-Yan Kwok, Rahul C Deo
Publikováno v:
eLife, Vol 4 (2015)
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein, sugges
Externí odkaz:
https://doaj.org/article/64ef752df04c4b96ab2dff639a70afb6
Autor:
Timo Buhl, Akihiko Ikoma, Cordula Kempkes, Ferda Cevikbas, Mathias Sulk, Joerg Buddenkotte, Tasuku Akiyama, Debbie Crumrine, Eric Camerer, Earl Carstens, Michael P. Schön, Peter Elias, Shaun R. Coughlin, Martin Steinhoff
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Activation of protease-activated receptor-2 (PAR2) has been implicated in inflammation, pruritus, and skin barrier regulation, all characteristics of atopic dermatitis (AD), as well as Netherton syndrome which has similar characteristics.
Externí odkaz:
https://doaj.org/article/c5bb5fb6a4bb4f2d83da1602d401752c
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
Autor:
Nathan Orr, Rima Arnaout, Lorne J. Gula, Danna A. Spears, Peter Leong-Sit, Qiuju Li, Wadea Tarhuni, Sven Reischauer, Vijay S. Chauhan, Matthew Borkovich, Shaheen Uppal, Arnon Adler, Shaun R. Coughlin, Didier Y. R. Stainier, Michael H. Gollob
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functiona
Externí odkaz:
https://doaj.org/article/3cbe2796738e4c49b3e6beec3f1f88fe
Autor:
Reuben Thomas, Terry Dean, Mark A. Petersen, Matthias G. Haberl, Jae K. Ryu, Victoria A. Rafalski, Andrew S. Mendiola, Eric A. Bushong, Keunyoung Kim, Daniel Naranjo Sampson, Elif G. Sozmen, Reshmi Tognatta, Rosa Meza Acevedo, Zhaoqi Yan, Shaun R. Coughlin, Mark H. Ellisman, Pamela E. Rios Coronado, Belinda S. Cabriga, Jorge J. Palop, Sophia Bardehle, Mario Merlini, Katerina Akassoglou, Matthew Madany, Keran Ma
Publikováno v:
Nature Neuroscience. 24:19-23
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating MgPTX mice to genetically inhibit Gi in microglia, we show that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d558dcdacc49cb06330157f8ecf84e06
https://doi.org/10.1038/s41593-020-00756-7
https://doi.org/10.1038/s41593-020-00756-7
Autor:
Xiaokun Shu, Qiang Zhang, Antonino Schepis, Wen Ma, Santi Nonell, Zhiqiang Dong, Thomas B. Kornberg, Junjiao Yang, Shao-Qing Zhang, Shaun R. Coughlin, Haifan Wu, Lina Yang, Hai Huang, Joaquim Torra
Publikováno v:
Journal of the American Chemical Society, vol 141, iss 11
A family of proteases called caspases mediate apoptosis signaling in animals. We report a GFP-based fluorogenic protease reporter, dubbed “FlipGFP”, by flipping a beta strand of the GFP. Upon protease activation and cleavage, the beta strand is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad286dbc3c90f7fa3bc9b444b4e0ee40
https://doi.org/10.1021/jacs.8b13042
https://doi.org/10.1021/jacs.8b13042
Autor:
Shaun R. Coughlin, Anna L. McGuire, Roy A Hilzenrat, Shaun Deen, John Yee, Ahmad S Ashrafi, Kyle Grant
Publikováno v:
Current Oncology
Volume 28
Issue 1
Pages 92-949
Current Oncology, Vol 28, Iss 92, Pp 940-949 (2021)
Volume 28
Issue 1
Pages 92-949
Current Oncology, Vol 28, Iss 92, Pp 940-949 (2021)
Background: COVID-19 has invariably changed the way lung cancer surgical care is provided in Canada. Despite relevant management guidelines, the way in which cancer care has been affected has yet to be described for thoracic surgical populations. Rou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2b49607a532d582b1afcc31f372280
Publikováno v:
Protein Science. 27:874-879
Detection of protein-protein interactions involved in signal transduction in live cells and organisms has a variety of important applications. We report a fluorogenic assay for G protein-coupled receptor (GPCR)-β-arrestin interaction that is genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b3a9e75c57ef07b48d6fa852faf70a
https://doi.org/10.1002/pro.3385
https://doi.org/10.1002/pro.3385
Autor:
Hyunil Jo, William F. DeGrado, Yoga Srinivasan, David E. Shaw, Ron O. Dror, Shaun R. Coughlin, Michael Grabe, James R. Valcourt, Albert C. Pan, Michael P. Bokoch, Sara Capponi
Publikováno v:
Biochemistry, vol 57, iss 39
The pathways that G protein-coupled receptor (GPCR) ligands follow as they bind to or dissociate from their receptors are largely unknown. Protease-activated receptor-1 (PAR1) is a GPCR activated by intramolecular binding of a tethered agonist peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cc10f18aa91a77f699cf29f1b515a0
https://europepmc.org/articles/PMC6584023/
https://europepmc.org/articles/PMC6584023/
Autor:
Antonino Schepis, Eaman Balouch, Chung-Der Hsiao, Yaowu Zheng, Yoga Srinivasan, Adrian Barker, Hilary Clay, Shaun R. Coughlin, Ian Lam
Publikováno v:
The Journal of cell biology, vol 217, iss 3
The Journal of Cell Biology
The Journal of Cell Biology
Mechanisms that sense and regulate epithelial morphogenesis and homeostasis are incompletely understood. Schepis et al. provide evidence that protease-activated receptor Par2b and matriptase, a membrane-tethered protease, can regulate apical extrusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532020f55694b09947870e30762bf751
https://escholarship.org/uc/item/2md5390p
https://escholarship.org/uc/item/2md5390p
Autor:
Akiko Hata, Xuan Jiang, Daniel O. Hart, Jamie McDonald, Melissa Sandoval, Mai Baalbaki, Giorgio Lagna, Whitney Wooderchak-Donahue, Shaun R. Coughlin, Pinar Bayrak-Toydemir, Hilary Clay, Prajakta Ghatpande
Publikováno v:
Science signaling, vol 11, iss 513
Jiang, Xuan; Wooderchak-Donahue, Whitney L; McDonald, Jamie; Ghatpande, Prajakta; Baalbaki, Mai; Sandoval, Melissa; et al.(2018). Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.. Science signaling, 11(513), eaan6831-eaan6831. doi: 10.1126/scisignal.aan6831. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1mh2x7w0
Jiang, Xuan; Wooderchak-Donahue, Whitney L; McDonald, Jamie; Ghatpande, Prajakta; Baalbaki, Mai; Sandoval, Melissa; et al.(2018). Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.. Science signaling, 11(513), eaan6831-eaan6831. doi: 10.1126/scisignal.aan6831. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1mh2x7w0
The transforming growth factor–β (TGF-β) and bone morphogenetic protein (BMP) family of cytokines critically regulates vascular morphogenesis and homeostasis. Impairment of TGF-β or BMP signaling leads to heritable vascular disorders, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f93f32bb541c3db26147892261c6c90
https://escholarship.org/uc/item/1mh2x7w0
https://escholarship.org/uc/item/1mh2x7w0