Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Shaun P. Brothers"'
Autor:
Shayan Khalafi, Shoumin Zhu, Rimpi Khurana, Ines Lohse, Silvia Giordano, Simona Corso, Hassan Al-Ali, Shaun P. Brothers, Claes Wahlestedt, Stephan Schürer, Wael El-Rifai
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101260- (2022)
Gastric cancer (GC) is frequently characterized by resistance to standard chemotherapeutic regimens and poor clinical outcomes. We aimed to identify a novel therapeutic approach using drug sensitivity testing (DST) and our computational SynerySeq pip
Externí odkaz:
https://doaj.org/article/8eeeb20b5800473cb4749dd0deb8d23c
Autor:
Sushmita Mustafi, Vladimir Camarena, Rehana Qureshi, Hyunho Yoon, Claude-Henry Volmar, Tyler C. Huff, David W. Sant, Lihong Zheng, Shaun P. Brothers, Claes Wahlestedt, Joyce Slingerland, Gaofeng Wang
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 201-210 (2019)
Background: Bromodomain and extra-terminal inhibitors (BETi) have shown efficacy for the treatment of aggressive triple negative breast cancer (TNBC). However, BETi are plagued by a narrow therapeutic window as manifested by severe toxicities at effe
Externí odkaz:
https://doaj.org/article/fc231bc797564622a0d7ba1e7b816b88
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthe
Externí odkaz:
https://doaj.org/article/b09c36362915423fa936bc15a22f2946
Autor:
Andrea L. Johnstone, Jiaqi J. O'Reilly, Annika J. Patel, Zhihong Guo, Nadja S. Andrade, Marco Magistri, Lubov Nathanson, Rustam Esanov, Brooke H. Miller, Gustavo Turecki, Shaun P. Brothers, Zane Zeier, Claes Wahlestedt
Publikováno v:
Neurobiology of Disease, Vol 119, Iss , Pp 149-158 (2018)
Background: With the capacity to modulate gene networks in an environmentally-sensitive manner, the role of epigenetic systems in mental disorders has come under intense investigation. Dysregulation of epigenetic effectors, including microRNAs and hi
Externí odkaz:
https://doaj.org/article/06de208a240d4bfebe4f66a49f8fd752
Autor:
Sabrina N. Copsel, Casey O. Lightbourn, Henry Barreras, Ines Lohse, Dietlinde Wolf, Cameron S. Bader, John Manov, Brandon J. Kale, Devangi Shah, Shaun P. Brothers, Victor L. Perez, Krishna V. Komanduri, Claes Wahlestedt, Robert B. Levy
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
A recent approach for limiting production of pro-inflammatory cytokines has been to target bromodomain and extra-terminal (BET) proteins. These epigenetic readers of histone acetylation regulate transcription of genes involved in inflammation, cardio
Externí odkaz:
https://doaj.org/article/9cc5a389d4de4657b305b7b1c9f3af61
Autor:
J. William Harbour, Shaun P. Brothers, Claes Wahlestedt, Claude-Henry Volmar, Evan R. Roberts, Daniel Bilbao, Stefan Kurtenbach, Nancy T. Chee, Daniel A. Rodriguez, Andy Lopez, Dawn A. Owens, Jeffim N. Kuznetsoff
S1. Doxycycline-inducible shRNA knockdown of BAP1 results in robust decrease of GLO1 expression in uveal melanoma cell lines. S2. Phenotypic rescue and toxicity analysis of three HDAC inhibitors in Xenopus embryos injected with control morpholino Ctr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a8332a4115f318e437e713772fac4
https://doi.org/10.1158/1541-7786.22525797
https://doi.org/10.1158/1541-7786.22525797
Autor:
J. William Harbour, Shaun P. Brothers, Claes Wahlestedt, Claude-Henry Volmar, Evan R. Roberts, Daniel Bilbao, Stefan Kurtenbach, Nancy T. Chee, Daniel A. Rodriguez, Andy Lopez, Dawn A. Owens, Jeffim N. Kuznetsoff
Table S2. Results of epigenetic library screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8be4d4f2503e2e7c8e28802ce3056b
https://doi.org/10.1158/1541-7786.22525791
https://doi.org/10.1158/1541-7786.22525791
Autor:
J. William Harbour, Shaun P. Brothers, Claes Wahlestedt, Claude-Henry Volmar, Evan R. Roberts, Daniel Bilbao, Stefan Kurtenbach, Nancy T. Chee, Daniel A. Rodriguez, Andy Lopez, Dawn A. Owens, Jeffim N. Kuznetsoff
Drug screens leading to successful targeted therapies in cancer have been mainly based on cell viability assays identifying inhibitors of dominantly acting oncogenes. In contrast, there has been little success in discovering targeted therapies that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c074db9c6f2e6bd3e5ef79951e44fd19
https://doi.org/10.1158/1541-7786.c.6544911.v1
https://doi.org/10.1158/1541-7786.c.6544911.v1
Autor:
J. William Harbour, Shaun P. Brothers, Claes Wahlestedt, Claude-Henry Volmar, Evan R. Roberts, Daniel Bilbao, Stefan Kurtenbach, Nancy T. Chee, Daniel A. Rodriguez, Andy Lopez, Dawn A. Owens, Jeffim N. Kuznetsoff
Table S1. Results of differential expression analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d46215d366c7212e6d2256e2f6582ed
https://doi.org/10.1158/1541-7786.22525794.v1
https://doi.org/10.1158/1541-7786.22525794.v1
Autor:
Jessica L. Dennison, Claude-Henry Volmar, Farzaneh Modarresi, Danbing Ke, James Wang, Emilie Gravel, Sabrina Hammond-Vignini, Zuomei Li, James A. Timmons, Ines Lohse, Marshall A. Hayward, Shaun P. Brothers, Claes Wahlestedt
Publikováno v:
Journal of Alzheimer's Disease. 86:173-190
Background: Alzheimer’s disease (AD) has minimally effective treatments currently. High concentrations of resveratrol, a polyphenol antioxidant found in plants, have been reported to affect several AD-related and neuroprotective genes. To address t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd0b4f38e5615bcf23085216c597189
https://doi.org/10.3233/jad-215370
https://doi.org/10.3233/jad-215370