Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shaun M Flint"'
Autor:
Emilio Fernandez-Egea, Petra E Vértes, Shaun M Flint, Lorinda Turner, Syed Mustafa, Alex Hatton, Kenneth G C Smith, Paul A Lyons, Edward T Bullmore
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155631 (2016)
BACKGROUND:Hypothetically, psychotic disorders could be caused or conditioned by immunological mechanisms. If so, one might expect there to be peripheral immune system phenotypes that are measurable in blood cells as biomarkers of psychotic states. M
Externí odkaz:
https://doaj.org/article/314733b1f6ca4ab1956a27bf4ee37dd4
Autor:
Kristina E N Clark, Eszter Csomor, Corrado Campochiaro, Nicholas Galwey, Katherine Nevin, Mary A Morse, Yee Voan Teo, Johannes Freudenberg, Voon H Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M Flint, Christopher P Denton
Publikováno v:
The Lancet. Rheumatology. 4(7)
Skin fibrosis is a hallmark feature of systemic sclerosis. Skin biopsy transcriptomics and blister fluid proteomics give insight into the local environment of the skin. We have integrated these modalities with the aim of developing a surrogate for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3e00b384b27941b2bda559dde5b9bd
https://pubmed.ncbi.nlm.nih.gov/36404995
https://pubmed.ncbi.nlm.nih.gov/36404995
Autor:
Shaun M. Flint, Corrado Campochiaro, Emma Derrett-Smith, Jennifer Singh, Christopher P. Denton, Nicholas Galwey, Adam Taylor, Katherine Nevin, Kristina Clark, Voon H Ong, Eszter Csomor, Nicolas Wisniacki, Yee Voan Teo, Mary A. Morse
Publikováno v:
Annals of the Rheumatic Diseases. 80:1584-1593
ObjectivesClinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark SSc autoantibodies are central to diagnosis and associate with distinct patterns of skin-based and organ-based complications. Understanding molecular differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfe0b2d30a93d414834be98b5dfacac
https://doi.org/10.1136/annrheumdis-2021-220402
https://doi.org/10.1136/annrheumdis-2021-220402
Autor:
Kristina E. N Clark, Eszter Csomor, Corrado Campochiaro, Yee Voan Teo, Johannes Freudenberg, Katherine Nevin, Mary A Morse, Voon H Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M Flint, Christopher P Denton
Publikováno v:
Rheumatology. 61
Background/Aims Suction blister fluid (BF) provides a unique opportunity to analyse the dermal microenvironment of SSc. We utilised an integrated approach to analyse proteomic data from dermal interstitial fluid and genome-wide transcriptomic data fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d4f61fe743f489dbec320ac96db257
https://doi.org/10.1093/rheumatology/keac133.228
https://doi.org/10.1093/rheumatology/keac133.228
Autor:
Shaun M. Flint, Adele Gibson, Geoff Lucas, Raghava Nandigam, Louise Taylor, Drew Provan, Adrian C. Newland, Caroline O. Savage, Robert B. Henderson
Publikováno v:
Haematologica, Vol 101, Iss 6 (2016)
Primary immune thrombocytopenia is an autoimmune disorder in which platelet destruction is a consequence of both B- and T-cell dysregulation. Flow cytometry was used to further characterize the B- and T-cell compartments in a cross-sectional cohort o
Externí odkaz:
https://doaj.org/article/d1183f911ffd472592f4f5494a930e6c
Autor:
Christopher P Denton, Francesco del Galdo, Dinesh Khanna, Madelon C Vonk, Lorinda Chung, Sindhu R Johnson, John Varga, Daniel E Furst, Jane Temple, Chiara Zecchin, Eszter Csomor, Amy Lee, Nicolas Wisniacki, Shaun M Flint, Juliet Reid
Publikováno v:
Rheumatology, 62, 1, pp. 234-242
Rheumatology, 62, 234-242
Rheumatology, 62, 234-242
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process. Methods This mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13191ea52197ebad936014af1ae8cb1
https://doi.org/10.1093/rheumatology/keac300
https://doi.org/10.1093/rheumatology/keac300
Autor:
Katherine Nevin, Shaun M. Flint, Voon H Ong, Christopher P. Denton, Emma Derrett-Smith, Corrado Campochiaro, Nicolas Wisniacki, Mary A. Morse, Kristina E N Clark, Adam Taylor, Eszter Csomor
Publikováno v:
Rheumatology. 60
Background/Aims Simultaneous analysis of multiple proteins in biological fluids offers insight into the pathogenesis of SSc. Here, we report a proteomic analysis of plasma and dermal interstitial fluid in SSc compared with healthy controls (HC). Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15814c2d8bf7602cadff9f9b8bbbc079
https://doi.org/10.1093/rheumatology/keab247.150
https://doi.org/10.1093/rheumatology/keab247.150
Autor:
Christopher P. Denton, Shaun M. Flint, Adam Taylor, Katherine Nevin, Nicolas Wisniacki, Corrado Campochiaro, Nicholas Galwey, Voon H Ong, Emma Derrett-Smith, Mary A. Morse, Kristina E N Clark, Eszter Csomor
Publikováno v:
Rheumatology. 60
Background/Aims The major antinuclear autoantibodies of systemic sclerosis (SSc) associate with different skin score trajectories and risk of internal organ manifestations. To elucidate molecular differences between ANA-defined subgroups, we utilised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8646ce52ae0ebc78c0a683b5124c21c2
https://doi.org/10.1093/rheumatology/keab246.017
https://doi.org/10.1093/rheumatology/keab246.017
Autor:
Elaine C. Jolly, Shaun M. Flint, Allyson Egan, David Jayne, Pasupathy Sivasothy, James E. Peters
Publikováno v:
Rheumatology (Oxford, England). 60(Suppl 3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428a88d16e500dafad18ca130c8b2acc
https://pubmed.ncbi.nlm.nih.gov/34137885
https://pubmed.ncbi.nlm.nih.gov/34137885
Autor:
Shaun M. Flint, Robert B Henderson, Christel Wilkinson, Beulah Ji, Roger A. Levy, Angela Jones-Leone, David M. Roth, Damon Bass, Mark Lennon
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Background Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecbfe68527fe70998e80dce8d2db595
http://europepmc.org/articles/PMC7197114
http://europepmc.org/articles/PMC7197114